TRIM11 tripartite motif containing 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM11provided by HGNC
Official Full Name: tripartite motif containing 11provided by HGNC
Primary source: HGNC:HGNC:16281
See related: Ensembl:ENSG00000154370 MIM:607868; AllianceGenome:HGNC:16281
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BIA1; RNF92
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 7.7), spleen (RPKM 6.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q42.13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (228393676..228406835, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (227582208..227595361, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (228581377..228594536, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
Title: TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
TRIM11 promotes cell proliferation of non-small cell lung cancer through the inhibition of ferroptosis by AMPK.
Title: TRIM11 promotes cell proliferation of non-small cell lung cancer through the inhibition of ferroptosis by AMPK.
TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease.
Title: TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease.
TRIM11 Posttranscriptionally Modulated by miR-5193 Facilitates Tumor Growth and Metastasis of Prostate Cancer.
Title: TRIM11 Posttranscriptionally Modulated by miR-5193 Facilitates Tumor Growth and Metastasis of Prostate Cancer.
TRIM11, a new target of p53, facilitates the migration and invasion of nasopharyngeal carcinoma cells.
Title: TRIM11, a new target of p53, facilitates the migration and invasion of nasopharyngeal carcinoma cells.
Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An Emerging Entity Analyzed in a Series of 41 Cases.
Title: Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An Emerging Entity Analyzed in a Series of 41 Cases.
Tripartite motif-containing protein 11 promotes hepatocellular carcinogenesis through ubiquitin-proteasome-mediated degradation of pleckstrin homology domain leucine-rich repeats protein phosphatase 1.
Title: Tripartite motif-containing protein 11 promotes hepatocellular carcinogenesis through ubiquitin-proteasome-mediated degradation of pleckstrin homology domain leucine-rich repeats protein phosphatase 1.
Sex-determining Region Y-box transcription factor 13 promotes breast cancer cell proliferation and glycolysis by activating the tripartite motif containing 11-mediated Wnt/beta-catenin signaling pathway.
Title: Sex-determining Region Y-box transcription factor 13 promotes breast cancer cell proliferation and glycolysis by activating the tripartite motif containing 11-mediated Wnt/β-catenin signaling pathway.
Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury via DUSP1-JNK1/2.
Title: Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury via DUSP1-JNK1/2.
Tripartite motif protein 11 (TRIM11), an oncogene for human lung cancer via the DUSP6-mediated ERK1/2 signaling pathway.
Title: Tripartite motif protein 11 (TRIM11), an oncogene for human lung cancer via the DUSP6-mediated ERK1/2 signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 infection is modestly restricted by human TRIM11 and downregulation of TRIM11 enhances virus release, suggesting the interaction between HIV-1 Gag and TRIM11	PubMed
Vpr	vpr	HIV-1 Vpr may indirectly regulate TRIM11 in a dose-dependent manner, which is independent of the ubiquitin system or VprBP-mediated pathway	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A009J23 (e-PCR)
- UniSTS:54531

G32582 (e-PCR)
- UniSTS:117165

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of AIM2 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral entry into host cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of viral entry into host cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in suppression of viral release by host	IDA Inferred from Direct Assay more info	PubMed
involved_in suppression of viral release by host	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM11

Names: RING finger protein 92; RING-type E3 ubiquitin transferase TRIM11; tripartite motif-containing protein 11

NP_660215.1

EC 2.3.2.27

XP_011542587.1

EC 2.3.2.27

XP_016857901.1

EC 2.3.2.27

XP_054194871.1

EC 2.3.2.27

XP_054194872.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145214.3 → NP_660215.1 E3 ubiquitin-protein ligase TRIM11

See identical proteins and their annotated locations for NP_660215.1

Status: REVIEWED

Source sequence(s)

AL670729

Consensus CDS

CCDS31048.1

UniProtKB/Swiss-Prot

A6NKE2, B2RB82, B3KUS3, B4DX88, Q5VSU1, Q8NCA6, Q96F44, Q9C022

Related

ENSP00000284551.6, ENST00000284551.11

Conserved Domains (3) summary

cd15811
Location:288 → 456

SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)

pfam00643
Location:87 → 128

zf-B_box; B-box zinc finger

cd16594
Location:13 → 57

RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

228393676..228406835 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011544285.4 → XP_011542587.1 E3 ubiquitin-protein ligase TRIM11 isoform X2

Conserved Domains (3) summary

pfam00643
Location:87 → 128

zf-B_box; B-box zinc finger

pfam15227
Location:16 → 56

zf-C3HC4_4; zinc finger of C3HC4-type, RING

cd15811
Location:211 → 379

SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)
XM_017002412.3 → XP_016857901.1 E3 ubiquitin-protein ligase TRIM11 isoform X1

UniProtKB/Swiss-Prot

Q96F44

Conserved Domains (3) summary

pfam00643
Location:87 → 128

zf-B_box; B-box zinc finger

pfam15227
Location:16 → 56

zf-C3HC4_4; zinc finger of C3HC4-type, RING

cd15811
Location:287 → 455

SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)