Habp2 hyaluronic acid binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Habp2provided by MGI
Official Full Name: hyaluronic acid binding protein 2provided by MGI
Primary source: MGI:MGI:1196378
See related: Ensembl:ENSMUSG00000025075 AllianceGenome:MGI:1196378
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FSAP; HABP; PHBP; HGFAL
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo endoderm; gut; liver; mitral valve; and yolk sac. Human ortholog(s) of this gene implicated in thrombophilia due to thrombin defect and thyroid gland papillary carcinoma. Orthologous to human HABP2 (hyaluronan binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 74.3), kidney adult (RPKM 71.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 51.79 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (56275541..56309252)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (56287109..56320820)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HABP2 Encapsulated by Peripheral Blood-Derived Exosomes Suppresses Astrocyte Autophagy to Exacerbate Neuroinflammatory Injury in Mice with Ischemic Stroke.
Title: HABP2 Encapsulated by Peripheral Blood-Derived Exosomes Suppresses Astrocyte Autophagy to Exacerbate Neuroinflammatory Injury in Mice with Ischemic Stroke.
Factor VII activating protease (FSAP) inhibits the outcome of ischemic stroke in mouse models.
Title: Factor VII activating protease (FSAP) inhibits the outcome of ischemic stroke in mouse models.
FSAP aggravated endothelial dysfunction and neurological deficits in acute ischemic stroke due to large vessel occlusion.
Title: FSAP aggravated endothelial dysfunction and neurological deficits in acute ischemic stroke due to large vessel occlusion.
FSAP deficiency causes an increase in CCL2 expression and CCL2-mediated infiltration of leukocytes into the injured vessel
Title: Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation.
the promoter activity, which could phenocopy changes in Habp2 mRNA in response to TGF-beta, was found to be located in the 177-bp region upstream of the transcription start site, and this region did not contain any SMAD binding sites.
Title: Transforming Growth Factor-β (TGF-β) Inhibits the Expression of Factor VII-activating Protease (FSAP) in Hepatocytes.
Lack of endogenous FSAP impaired the formation of stable, occlusive thrombi in mice.
Title: Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP).
Results show that the lack of FSAP in mice worsens the outcome of stroke; in the absence of FSAP there was a stronger inflammatory response and lower cell survival due to insufficient activation of the PI3K/AKT pathway
Title: Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice.
Lower FSAP expression is associated with enhanced liver fibrosis and inflammation in patients with chronic hepatic disorders and murine experimental liver injury.
Title: Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men.
Data indicate that FSAP mediates proteolytic cleavage and activation of bone morphogenetic protein-2 (BMP-2).
Title: The factor VII-activating protease (FSAP) enhances the activity of bone morphogenetic protein-2 (BMP-2).
Hyaluronic acid binding protein 2 (HABP2) negatively regulates vascular integrity via activation of protease-activated receptor/RhoA/Rho kinase signaling. It represents a potential therapeutic target for syndromes of increased vascular permeability.
Title: Hyaluronic Acid binding protein 2 is a novel regulator of vascular integrity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI035669 (e-PCR)
- UniSTS:166163

Habp2 (e-PCR), detects polymorphism
- UniSTS:516137

Habp2 (e-PCR), detects polymorphism
- UniSTS:525495

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hyaluronan-binding protein 2

Names: hyaduronic acid-binding protein 2; plasma hyaluronan-binding protein

NP_001316864.1

EC 3.4.21.92

NP_001316865.1

EC 3.4.21.92

NP_666213.1

EC 3.4.21.92

XP_006527077.1

EC 3.4.21.92

XP_017173656.1

EC 3.4.21.92

XP_030106767.1

EC 3.4.21.92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001329935.1 → NP_001316864.1 hyaluronan-binding protein 2 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).

Source sequence(s)

AC115771, AC161579, AK132407, BB569555

Consensus CDS

CCDS89419.1

UniProtKB/Swiss-Prot

Q8K0D2

UniProtKB/TrEMBL

E9QM92

Conserved Domains (3) summary

cd00054
Location:67 → 103

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00108
Location:187 → 271

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:308 → 547

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001329936.1 → NP_001316865.1 hyaluronan-binding protein 2 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks multiple exons in the 3' coding region and contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC161579, AK132407, AK149504

UniProtKB/TrEMBL

Q3UEI7

Related

ENSMUST00000165407.2

Conserved Domains (1) summary

cd00054
Location:67 → 103

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
NM_146101.2 → NP_666213.1 hyaluronan-binding protein 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_666213.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AC115771, AC161579, AK132407

Consensus CDS

CCDS50475.1

UniProtKB/Swiss-Prot

Q8K0D2

UniProtKB/TrEMBL

Q3V1J8

Related

ENSMUSP00000093641.5, ENSMUST00000095948.11

Conserved Domains (4) summary

smart00020
Location:270 → 507

Tryp_SPc; Trypsin-like serine protease

cd00054
Location:30 → 66

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00108
Location:150 → 234

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:271 → 510

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

56275541..56309252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527014.3 → XP_006527077.1 hyaluronan-binding protein 2 isoform X1

See identical proteins and their annotated locations for XP_006527077.1

UniProtKB/Swiss-Prot

Q8K0D2

UniProtKB/TrEMBL

E9QM92

Related

ENSMUSP00000077402.7, ENSMUST00000078284.13

Conserved Domains (3) summary

cd00054
Location:67 → 103

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00108
Location:187 → 271

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:308 → 547

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_030250907.1 → XP_030106767.1 hyaluronan-binding protein 2 isoform X3

UniProtKB/TrEMBL

Q3UEI7

Conserved Domains (1) summary

cd00054
Location:67 → 103

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_017318167.1 → XP_017173656.1 hyaluronan-binding protein 2 isoform X2

Conserved Domains (2) summary

cd00190
Location:85 → 324

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cl00100
Location:9 → 48

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...