Pls1 plastin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pls1provided by RGD
Official Full Name: plastin 1provided by RGD
Primary source: RGD:1307142
See related: Ensembl:ENSRNOG00000009945 AllianceGenome:RGD:1307142
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including actin filament organization; inner ear receptor cell stereocilium organization; and intestinal D-glucose absorption. Predicted to act upstream of or within terminal web assembly. Predicted to be located in brush border; stereocilium; and terminal web. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 189.2), Liver (RPKM 95.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (105196312..105306252, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (96316703..96426592, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (103557361..103659625, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in auditory receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in intestinal D-glucose absorption	ISO Inferred from Sequence Orthology more info
NOT involved_in microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of microvillus length	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within terminal web assembly	ISO Inferred from Sequence Orthology more info
involved_in terminal web assembly	ISO Inferred from Sequence Orthology more info
involved_in vestibular receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in terminal web	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plastin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108178.2 → NP_001101648.2 plastin-1

See identical proteins and their annotated locations for NP_001101648.2

Status: PROVISIONAL

Source sequence(s)

BC168847

UniProtKB/TrEMBL

B5DEY0, F1LQQ6

Conserved Domains (3) summary

smart00033
Location:233 → 336

CH; Calponin homology domain

cd00014
Location:100 → 210

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00307
Location:351 → 454

CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

105196312..105306252 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081542.2 → XP_038937470.1 plastin-1 isoform X1

UniProtKB/TrEMBL

A0A0G2QC04

Conserved Domains (2) summary

COG5069
Location:13 → 622

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cl00030
Location:100 → 244

CH_SF; calponin homology (CH) domain superfamily
XM_006243574.4 → XP_006243636.1 plastin-1 isoform X1

See identical proteins and their annotated locations for XP_006243636.1

UniProtKB/TrEMBL

A0A0G2QC04

Related

ENSRNOP00000013209.7

Conserved Domains (2) summary

COG5069
Location:13 → 622

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cl00030
Location:100 → 244

CH_SF; calponin homology (CH) domain superfamily
XM_063265574.1 → XP_063121644.1 plastin-1 isoform X1

UniProtKB/TrEMBL

A0A0G2QC04