mst1 macrophage stimulating 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mst1provided by ZNC
Official Full Name: macrophage stimulating 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-020806-3
See related: Ensembl:ENSDARG00000103308 AllianceGenome:ZFIN:ZDB-GENE-020806-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb981; hgfl1
Summary: Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within bone mineralization and inflammatory response. Predicted to be active in extracellular space. Is expressed in digestive system; margin; and yolk syncytial layer. Used to study inflammatory bowel disease. Orthologous to several human genes including MST1 (macrophage stimulating 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (53394125..53426773, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (53393746..53426394, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show the Msp/Ron signaling axis as a previously unappreciated player in calcium homeostasis and embryonic skeletal mineralization.
Title: Macrophage-stimulating protein and calcium homeostasis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
NOT enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hepatocyte growth factor-like protein

Names: macrophage stimulating 1 (hepatocyte growth factor-like); macrophage-stimulating protein; msp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152980.1 → NP_694512.1 hepatocyte growth factor-like protein precursor

See identical proteins and their annotated locations for NP_694512.1

Status: PROVISIONAL

Source sequence(s)

AF370035

UniProtKB/TrEMBL

Q90ZN6

Related

ENSDARP00000132446.1, ENSDART00000162791.2

Conserved Domains (5) summary

smart00020
Location:481 → 702

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:192 → 271

KR; Kringle domain

cd00108
Location:370 → 451

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:482 → 705

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cd01099
Location:24 → 105

PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...