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    Lgr5 leucine rich repeat containing G protein coupled receptor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299802, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Lgr5provided by RGD
    Official Full Name
    leucine rich repeat containing G protein coupled receptor 5provided by RGD
    Primary source
    RGD:1307733
    See related
    Ensembl:ENSRNOG00000004221 AllianceGenome:RGD:1307733
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr49
    Summary
    Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in several processes, including activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; and positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; hair follicle development; and oocyte differentiation. Predicted to be located in nucleoplasm and trans-Golgi network membrane. Predicted to be integral component of plasma membrane. Orthologous to human LGR5 (leucine rich repeat containing G protein-coupled receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Uterus (RPKM 35.4), Brain (RPKM 16.7) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lgr5 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (52973151..53107964, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (51087059..51221882, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (58447097..58587787, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene zinc finger, C3H1-type containing Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 42 Neighboring gene MICOS complex subunit Mic10-like Neighboring gene transfer RNA proline (anticodon AGG) 57 Neighboring gene 39S ribosomal protein L50, mitochondrial-like Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene uncharacterized LOC134479871

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Temporal and Spatial Expression of LGR5 After Acute Spinal Cord Injury in Adult Rats. Chen X, et al. Neurochem Res, 2016 Oct. PMID 27339869
    2. Influence of stress factors on intestinal epithelial injury and regeneration. Lee C, et al. Pediatr Surg Int, 2018 Feb. PMID 29018960
    3. Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer. Junttila MR, et al. Sci Transl Med, 2015 Nov 18. PMID 26582901
    4. Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. Snyder JC, et al. J Biol Chem, 2013 Apr 12. PMID 23439653, Free PMC Article
    5. Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin. Femia AP, et al. BMC Cancer, 2013 Feb 1. PMID 23374535, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-6 expression increased in all groups compared to control. Lgr5 expression was up-regulated in cells exposed to a single stressor, but down-regulated when multiple stressors were administered.
      Title: Influence of stress factors on intestinal epithelial injury and regeneration.
    2. that Leucine-rich repeat-containing G-protein coupled receptor 5might be of great significance in CNS pathophysiology after spinal cord injury
      Title: Temporal and Spatial Expression of LGR5 After Acute Spinal Cord Injury in Adult Rats.
    3. Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.
      Title: Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer.
    4. Results support LGR-5 as a putative neoplastic stem cell marker in colonic tumors co-expressing nuclear beta-catenin.
      Title: Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within epithelial cell proliferation involved in renal tubule morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner ear development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing G-protein coupled receptor 5
    Names
    G protein-coupled receptor 49

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106784.1 → NP_001100254.1  leucine-rich repeat-containing G-protein coupled receptor 5 precursor

      See identical proteins and their annotated locations for NP_001100254.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/Swiss-Prot
      D4AC13
      UniProtKB/TrEMBL
      A0A8I6ARJ9
      Related
      ENSRNOP00000005814.3, ENSRNOT00000005814.5
      Conserved Domains (6) summary
      smart00013
      Location:33 → 70
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:88 → 372
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:445 → 467
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:68 → 91
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:575 → 820
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam13855
      Location:92 → 150
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      52973151..53107964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263222.1 → XP_063119292.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARJ9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4AC13.1 GenPept UniProtKB/Swiss-Prot:D4AC13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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