hectd1 HECT domain containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hectd1provided by ZNC
Official Full Name: HECT domain containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-153
See related: Ensembl:ENSDARG00000054213 AllianceGenome:ZFIN:ZDB-GENE-030616-153
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92832; wu:fc30d02; wu:fc49f09; wu:fd99d04; zgc:123053; si:dz142b24.4
Summary: Predicted to enable metal ion binding activity and ubiquitin-protein transferase activity. Predicted to be involved in anatomical structure development and protein K63-linked ubiquitination. Predicted to act upstream of or within protein ubiquitination. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (28670132..28701283)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (28653169..28684320)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc30d02.x1 (e-PCR)
- UniSTS:187932

AW165043 (e-PCR)
- UniSTS:205893

fc49f09 (e-PCR)
- UniSTS:189258

G40281 (e-PCR)
- UniSTS:48988

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase HECTD1

NP_001002504.2

EC 2.3.2.26

XP_009291386.1

EC 2.3.2.26

XP_009291387.1

EC 2.3.2.26

XP_009291388.1

EC 2.3.2.26

XP_009291389.1

EC 2.3.2.26

XP_009291390.1

EC 2.3.2.26

XP_009291391.1

EC 2.3.2.26

XP_009291392.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002504.2 → NP_001002504.2 E3 ubiquitin-protein ligase HECTD1

See identical proteins and their annotated locations for NP_001002504.2

Status: PROVISIONAL

Source sequence(s)

AL593845

UniProtKB/TrEMBL

A0A8M1N0I1, Q8JFV5

Related

ENSDARP00000139204.1, ENSDART00000159067.2

Conserved Domains (7) summary

smart00119
Location:2121 → 2573

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:2097 → 2574

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00204
Location:369 → 479

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam06701
Location:1277 → 1335

MIB_HERC2; Mib_herc2

pfam12796
Location:366 → 457

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:396 → 426

ANK; ANK repeat [structural motif]

cl23730
Location:1107 → 1240

F5_F8_type_C; F5/8 type C domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

28670132..28701283

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009293111.3 → XP_009291386.1 E3 ubiquitin-protein ligase HECTD1 isoform X1

UniProtKB/TrEMBL

A0A8M3AJX0

Conserved Domains (7) summary

smart00119
Location:2130 → 2582

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:2106 → 2583

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00204
Location:369 → 479

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam06701
Location:1277 → 1335

MIB_HERC2; Mib_herc2

pfam12796
Location:366 → 457

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:396 → 426

ANK; ANK repeat [structural motif]

cl23730
Location:1107 → 1240

F5_F8_type_C; F5/8 type C domain
XM_009293114.3 → XP_009291389.1 E3 ubiquitin-protein ligase HECTD1 isoform X4

UniProtKB/TrEMBL

A0A8M3AJ23

Conserved Domains (7) summary

smart00119
Location:2069 → 2521

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:2045 → 2522

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00204
Location:369 → 479

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam06701
Location:1277 → 1335

MIB_HERC2; Mib_herc2

pfam12796
Location:366 → 457

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:396 → 426

ANK; ANK repeat [structural motif]

cl23730
Location:1107 → 1240

F5_F8_type_C; F5/8 type C domain
XM_009293112.3 → XP_009291387.1 E3 ubiquitin-protein ligase HECTD1 isoform X2

UniProtKB/TrEMBL

A0A2R8PW57, A0A8M3AUC7

Related

ENSDARP00000145151.1, ENSDART00000182851.1

Conserved Domains (7) summary

smart00119
Location:2115 → 2567

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:2091 → 2568

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00204
Location:369 → 479

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam06701
Location:1277 → 1335

MIB_HERC2; Mib_herc2

pfam12796
Location:366 → 457

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:396 → 426

ANK; ANK repeat [structural motif]

cl23730
Location:1107 → 1240

F5_F8_type_C; F5/8 type C domain
XM_009293115.3 → XP_009291390.1 E3 ubiquitin-protein ligase HECTD1 isoform X5

UniProtKB/TrEMBL

A0A0R4IGL6, A0A8M3B2H1

Related

ENSDARP00000133558.1, ENSDART00000164981.2

Conserved Domains (7) summary

smart00119
Location:2054 → 2506

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:2030 → 2507

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00204
Location:369 → 479

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam06701
Location:1277 → 1335

MIB_HERC2; Mib_herc2

pfam12796
Location:366 → 457

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:396 → 426

ANK; ANK repeat [structural motif]

cl23730
Location:1107 → 1240

F5_F8_type_C; F5/8 type C domain
XM_009293117.3 → XP_009291392.1 E3 ubiquitin-protein ligase HECTD1 isoform X7

UniProtKB/TrEMBL

A0A8M3AUD5

Conserved Domains (7) summary

smart00119
Location:2068 → 2520

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:2044 → 2521

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00204
Location:369 → 479

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam06701
Location:1277 → 1321

MIB_HERC2; Mib_herc2

pfam12796
Location:366 → 457

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:396 → 426

ANK; ANK repeat [structural motif]

cl23730
Location:1107 → 1240

F5_F8_type_C; F5/8 type C domain
XM_009293113.3 → XP_009291388.1 E3 ubiquitin-protein ligase HECTD1 isoform X3

UniProtKB/TrEMBL

A0A8M3ARF8

Conserved Domains (7) summary

smart00119
Location:2083 → 2535

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:2059 → 2536

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00204
Location:369 → 479

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam06701
Location:1277 → 1321

MIB_HERC2; Mib_herc2

pfam12796
Location:366 → 457

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:396 → 426

ANK; ANK repeat [structural motif]

cl23730
Location:1107 → 1240

F5_F8_type_C; F5/8 type C domain
XM_009293116.3 → XP_009291391.1 E3 ubiquitin-protein ligase HECTD1 isoform X6

UniProtKB/TrEMBL

A0A8M3AJX5

Conserved Domains (5) summary

cd00204
Location:369 → 479

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam06701
Location:1277 → 1302

MIB_HERC2; Mib_herc2

pfam12796
Location:366 → 457

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:396 → 426

ANK; ANK repeat [structural motif]

cl23730
Location:1107 → 1240

F5_F8_type_C; F5/8 type C domain