CAPN11 calpain 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CAPN11provided by HGNC
Official Full Name: calpain 11provided by HGNC
Primary source: HGNC:HGNC:1478
See related: Ensembl:ENSG00000137225 MIM:604822; AllianceGenome:HGNC:1478
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: calpain11
Summary: Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]
Expression: Restricted expression toward testis (RPKM 18.7) See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.1

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (44158820..44184401)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (43992275..44018561)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (44126557..44152138)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of a related mouse gene and comparison of the protein to the human protein.
Title: Calpain 11 is unique to mouse spermatogenic cells.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calpain-11

Names: CANP 11; calcium-activated neutral proteinase 11

NP_008989.2

EC 3.4.22.17

XP_006715047.1

EC 3.4.22.17

XP_006715048.1

EC 3.4.22.17

XP_006715050.1

EC 3.4.22.17

XP_011512576.1

EC 3.4.22.17

XP_011512577.1

EC 3.4.22.17

XP_054210100.1

EC 3.4.22.17

XP_054210101.1

EC 3.4.22.17

XP_054210102.1

EC 3.4.22.17

XP_054210103.1

EC 3.4.22.17

XP_054210104.1

EC 3.4.22.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007058.4 → NP_008989.2 calpain-11

See identical proteins and their annotated locations for NP_008989.2

Status: REVIEWED

Source sequence(s)

AJ242832, BC033733, DB052011

Consensus CDS

CCDS47436.1

UniProtKB/Swiss-Prot

B2RA64, Q5T3G1, Q8N4R5, Q9UMQ6

Related

ENSP00000381758.1, ENST00000398776.2

Conserved Domains (3) summary

pfam00648
Location:80 → 376

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:390 → 544

Calpain_III; Calpain large subunit, domain III

cl08302
Location:615 → 665

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

44158820..44184401

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011514274.2 → XP_011512576.1 calpain-11 isoform X3

Conserved Domains (3) summary

pfam00648
Location:85 → 381

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:395 → 549

Calpain_III; Calpain large subunit, domain III

cl08302
Location:620 → 670

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_011514275.1 → XP_011512577.1 calpain-11 isoform X4

Conserved Domains (3) summary

pfam00648
Location:84 → 380

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:394 → 548

Calpain_III; Calpain large subunit, domain III

cl08302
Location:619 → 669

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_006714984.2 → XP_006715047.1 calpain-11 isoform X1

Conserved Domains (3) summary

pfam00648
Location:81 → 377

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:391 → 545

Calpain_III; Calpain large subunit, domain III

cl08302
Location:616 → 666

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_006714985.2 → XP_006715048.1 calpain-11 isoform X2

Conserved Domains (3) summary

pfam00648
Location:81 → 377

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:391 → 545

Calpain_III; Calpain large subunit, domain III

cl08302
Location:616 → 666

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_006714987.2 → XP_006715050.1 calpain-11 isoform X5

Conserved Domains (2) summary

pfam00648
Location:81 → 377

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:391 → 545

Calpain_III; Calpain large subunit, domain III