wdr76 WD repeat domain 76 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr76provided by ZNC
Official Full Name: WD repeat domain 76provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4513
See related: Ensembl:ENSDARG00000053554 AllianceGenome:ZFIN:ZDB-GENE-030131-4513
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7148605; wu:fd11f08
Summary: Predicted to enable DNA binding activity. Predicted to be involved in regulation of DNA damage checkpoint. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be active in nucleus. Orthologous to human WDR76 (WD repeat domain 76). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (30201600..30209790)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (29930461..29938640)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of DNA damage checkpoint	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein 76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198567.1 → NP_001185496.1 WD repeat-containing protein 76

Status: PROVISIONAL

Source sequence(s)

CR356246

UniProtKB/TrEMBL

A0A8M1NW89, E7FER1

Related

ENSDARP00000070070.5, ENSDART00000075588.6

Conserved Domains (3) summary

COG2319
Location:239 → 551

WD40; WD40 repeat [General function prediction only]

sd00039
Location:251 → 291

7WD40; WD40 repeat [structural motif]

cl02567
Location:249 → 551

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

30201600..30209790

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477578.1 → XP_021333253.1 WD repeat-containing protein 76 isoform X1

UniProtKB/TrEMBL

A0A8M9Q1Q9

Conserved Domains (2) summary

sd00039
Location:252 → 292

7WD40; WD40 repeat [structural motif]

cl25539
Location:250 → 552

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...