ctsf cathepsin F [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ctsfprovided by ZNC
Official Full Name: cathepsin Fprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9831
See related: Ensembl:ENSDARG00000063095 AllianceGenome:ZFIN:ZDB-GENE-030131-9831
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb420; sb:cb420; zgc:153093
Summary: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in mesoderm; nervous system; neural tube; solid lens vesicle; and ventral mesenchyme. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 13. Orthologous to human CTSF (cathepsin F). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (7140965..7188265)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (6834549..6858237)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cathepsin F

NP_001071036.1

EC 3.4.22.41

XP_005157210.1

EC 3.4.22.41

XP_021336715.1

EC 3.4.22.41

XP_021336716.1

EC 3.4.22.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077568.1 → NP_001071036.1 cathepsin F precursor

See identical proteins and their annotated locations for NP_001071036.1

Status: PROVISIONAL

Source sequence(s)

BC124243

UniProtKB/TrEMBL

Q08CH0

Related

ENSDARP00000112297.1, ENSDART00000129898.3

Conserved Domains (4) summary

PTZ00203
Location:143 → 472

PTZ00203; cathepsin L protease; Provisional

smart00043
Location:34 → 144

CY; Cystatin-like domain

smart00848
Location:175 → 231

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:262 → 471

Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

7140965..7188265

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021481041.1 → XP_021336716.1 cathepsin F isoform X1

UniProtKB/TrEMBL

A0A8M9QKM5, F1RE14

Conserved Domains (3) summary

smart00043
Location:34 → 144

CY; Cystatin-like domain

smart00848
Location:175 → 231

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:262 → 471

Peptidase_C1; Papain family cysteine protease
XM_021481040.1 → XP_021336715.1 cathepsin F isoform X1

UniProtKB/TrEMBL

A0A8M9QKM5, F1RE14

Conserved Domains (3) summary

smart00043
Location:34 → 144

CY; Cystatin-like domain

smart00848
Location:175 → 231

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:262 → 471

Peptidase_C1; Papain family cysteine protease
XM_005157153.4 → XP_005157210.1 cathepsin F isoform X1

UniProtKB/TrEMBL

A0A8M9QKM5, F1RE14

Related

ENSDARP00000132041.1, ENSDART00000170994.2

Conserved Domains (3) summary

smart00043
Location:34 → 144

CY; Cystatin-like domain

smart00848
Location:175 → 231

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:262 → 471

Peptidase_C1; Papain family cysteine protease