eag ether a go-go [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eagprovided by FlyBase
Official Full Name: ether a go-goprovided by FlyBase
Primary source: FLYBASE:FBgn0000535
Locus tag: Dmel_CG10952
See related: AllianceGenome:FB:FBgn0000535
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10952; CIKE; Dmel\CG10952; Eag; EAG
Summary: Enables transmembrane transporter binding activity and voltage-gated potassium channel activity. Involved in learning; perineurial glial growth; and positive regulation of voltage-gated potassium channel activity. Located in plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in adult head. Used to study epilepsy. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including KCNH5 (potassium voltage-gated channel subfamily H member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 13A1-13A5; 1-49 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (14955477..15009989)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (14849510..14904022)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest the dEAG channel is a docking platform for the protein kinase CaMKII and that phosphorylation of the channel's kinase recognition sequence modulates the strength of the interaction between the channel and the kinase.
Title: The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase.
These results show that even a minor change in amino acid side-chain chemistry and size can have a dramatic impact on channel biophysics, and that RNA editing is important for fine-tuning eag channel's function.
Title: RNA editing in eag potassium channels: biophysical consequences of editing a conserved S6 residue.
our results provide evidence that EAG represents a unique K(+) channel contributing to multiple K(+) currents in motoneurons helping to regulate excitability, consistent with previous observations in the Drosophila larval muscle.
Title: Contribution of EAG to excitability and potassium currents in Drosophila larval motoneurons.
results suggest an important role of the intracellular regions in the generation of Eag currents
Title: Intracellular regions of the Eag potassium channel play a critical role in generation of voltage-dependent currents.
Results suggest an important role of the intracellular linker regions in Mg-dependent gating processes of Eag channels.
Title: Intracellular linkers are involved in Mg2+-dependent modulation of the Eag potassium channel.
phosphorylated and regulated by calcium/calmodulin-dependent protein kinase II
Title: Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel.
eag potassium channel binds and locally activates calcium/calmodulin-dependent protein kinase II
Title: The eag potassium channel binds and locally activates calcium/calmodulin-dependent protein kinase II.
positioning of S6 aromatic residues relative to the central cavity of the channel, not inactivation per se determines drug block of HERG or eag channels
Title: Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels.
G297E substitution may cause premature, prolonged, or constitutive opening of the Eag channels by favoring the "unlocked" state of the channel
Title: In vivo analysis of a gain-of-function mutation in the Drosophila eag-encoded K+ channel.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral response to ether	NAS Non-traceable Author Statement more info	PubMed
involved_in courtship behavior	NAS Non-traceable Author Statement more info	PubMed
involved_in courtship behavior	TAS Traceable Author Statement more info	PubMed
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	NAS Non-traceable Author Statement more info	PubMed
involved_in perineurial glial growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in regulation of heart contraction	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of smell	NAS Non-traceable Author Statement more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IPI Inferred from Physical Interaction more info	PubMed
part_of voltage-gated potassium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: ether a go-go

Names: CG10952-PA; CG10952-PB; CG10952-PC; CG10952-PD; CG10952-PE; CG10952-PF; CG10952-PG; eag-PA; eag-PB; eag-PC; eag-PD; eag-PE; eag-PF; eag-PG; ether-a go-go; ether-a-go-go; ether-a-gogo

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

14955477..15009989

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001042810.3 → NP_001036275.1 ether a go-go, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036275.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0KHS8

Conserved Domains (6) summary

COG0664
Location:565 → 702

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:571 → 682

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:40 → 153

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00520
Location:254 → 499

Ion_trans; Ion transport protein

pfam07885
Location:440 → 494

Ion_trans_2; Ion channel

pfam13426
Location:28 → 155

PAS_9; PAS domain
NM_078603.4 → NP_511158.2 ether a go-go, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511158.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02280, Q9VXZ6

Related

FBpp0073772

Conserved Domains (6) summary

COG0664
Location:565 → 702

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:571 → 682

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:40 → 153

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00520
Location:254 → 499

Ion_trans; Ion transport protein

pfam07885
Location:440 → 494

Ion_trans_2; Ion channel

pfam13426
Location:28 → 155

PAS_9; PAS domain
NM_001272629.1 → NP_001259558.1 ether a go-go, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259558.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHM3

Conserved Domains (6) summary

COG0664
Location:548 → 685

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:554 → 665

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:40 → 136

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00520
Location:237 → 482

Ion_trans; Ion transport protein

pfam07885
Location:423 → 477

Ion_trans_2; Ion channel

pfam13426
Location:28 → 138

PAS_9; PAS domain
NM_001201663.2 → NP_001188592.1 ether a go-go, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188592.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MSA6

Conserved Domains (6) summary

COG0664
Location:563 → 700

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:569 → 680

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:40 → 151

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00520
Location:252 → 497

Ion_trans; Ion transport protein

pfam07885
Location:438 → 492

Ion_trans_2; Ion channel

pfam13426
Location:28 → 153

PAS_9; PAS domain
NM_001272628.1 → NP_001259557.1 ether a go-go, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259557.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAD4, M9PHT2

Conserved Domains (4) summary

cd00130
Location:40 → 136

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00520
Location:244 → 489

Ion_trans; Ion transport protein

pfam07885
Location:430 → 484

Ion_trans_2; Ion channel

pfam13426
Location:28 → 138

PAS_9; PAS domain
NM_001201662.2 → NP_001188591.1 ether a go-go, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188591.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAD4, M9MSD1

Conserved Domains (2) summary

pfam00520
Location:221 → 482

Ion_trans; Ion transport protein

pfam13426
Location:28 → 138

PAS_9; PAS domain
NM_001272627.1 → NP_001259556.1 ether a go-go, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259556.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAD4, M9PH56

Conserved Domains (2) summary

pfam00520
Location:219 → 480

Ion_trans; Ion transport protein

pfam13426
Location:28 → 138

PAS_9; PAS domain