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    tgm1l3 transglutaminase 1 like 3 [ Danio rerio (zebrafish) ]

    Gene ID: 793448, updated on 25-Apr-2024

    Summary

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    Official Symbol
    tgm1l3provided by ZNC
    Official Full Name
    transglutaminase 1 like 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120718-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-120718-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable metal ion binding activity and protein-glutamine gamma-glutamyltransferase activity. Predicted to act upstream of or within peptide cross-linking. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1. Orthologous to human TGM1 (transglutaminase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See tgm1l3 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (40234646..40276231, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (40277504..40297530)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene transglutaminase 1 like 2 Neighboring gene transglutaminase 1-like 6 Neighboring gene terminal nucleotidyltransferase 5Ab Neighboring gene ELOVL fatty acid elongase 4b Neighboring gene MTCL family member 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of the transglutaminase gene family in zebrafish and in vivo analysis of transglutaminase-dependent bone mineralization. Deasey S, et al. Amino Acids, 2012 Feb. PMID 21809079, Free PMC Article
    2. Generation of a double binary transgenic zebrafish model to study myeloid gene regulation in response to oncogene activation in melanocytes. Kenyon A, et al. Dis Model Mech, 2018 Apr 6. PMID 29666124, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within keratinization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-glutamine gamma-glutamyltransferase K-like
    Names
    TG1-48

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      40234646..40276231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001331878.8 → XP_001331914.1  protein-glutamine gamma-glutamyltransferase K-like

      UniProtKB/TrEMBL
      A0A8M1Q6T7
      Conserved Domains (5) summary
      smart00460
      Location:429 → 520
      TGc; Transglutaminase/protease-like homologues
      COG1305
      Location:428 → 565
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam00868
      Location:166 → 283
      Transglut_N; Transglutaminase family
      pfam00927
      Location:761 → 846
      Transglut_C; Transglutaminase family, C-terminal ig like domain
      pfam02389
      Location:42 → 128
      Cornifin; Cornifin (SPRR) family
    Nucleotide Protein Strain
    Heading Accession and Version

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