Nbeal2 neurobeachin-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nbeal2provided by RGD
Official Full Name: neurobeachin-like 2provided by RGD
Primary source: RGD:1306501
See related: Ensembl:ENSRNOG00000027880 AllianceGenome:RGD:1306501
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nbeal2-ps1; RGD1306501
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in platelet formation and protein localization. Predicted to act upstream of or within blood coagulation; megakaryocyte development; and platelet alpha granule organization. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and membrane. Human ortholog(s) of this gene implicated in gray platelet syndrome. Orthologous to human NBEAL2 (neurobeachin like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 73.1), Spleen (RPKM 64.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 56

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (119481608..119511997, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (110603220..110633612, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (118893987..118924390, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within megakaryocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet alpha granule organization	ISO Inferred from Sequence Orthology more info
involved_in platelet formation	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neurobeachin-like protein 2

Names: neurobeachin-like 2, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427320.1 → NP_001414249.1 neurobeachin-like protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6A0G8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

119481608..119511997 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082645.2 → XP_038938573.1 neurobeachin-like protein 2 isoform X5

Conserved Domains (6) summary

smart01026
Location:2011 → 2291

Beach; Beige/BEACH domain

cd01201
Location:1889 → 1989

PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

sd00039
Location:2409 → 2446

7WD40; WD40 repeat [structural motif]

pfam15787
Location:851 → 1100

DUF4704; Domain of unknown function (DUF4704)

pfam16057
Location:1566 → 1832

DUF4800; Domain of unknown function (DUF4800)

cl29593
Location:2410 → 2659

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_003750591.6 → XP_003750639.1 neurobeachin-like protein 2 isoform X3

See identical proteins and their annotated locations for XP_003750639.1

UniProtKB/TrEMBL

A0A8I6A5B7

Related

ENSRNOP00000088549.1

Conserved Domains (7) summary

COG2319
Location:2434 → 2684

WD40; WD40 repeat [General function prediction only]

cd01201
Location:1889 → 2014

PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

pfam02138
Location:2037 → 2316

Beach; Beige/BEACH domain

pfam15787
Location:851 → 1100

DUF4704; Domain of unknown function (DUF4704)

pfam16057
Location:1566 → 1832

DUF4800; Domain of unknown function (DUF4800)

sd00039
Location:2434 → 2471

7WD40; WD40 repeat [structural motif]

cl02567
Location:2435 → 2684

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006244009.5 → XP_006244071.1 neurobeachin-like protein 2 isoform X2

See identical proteins and their annotated locations for XP_006244071.1

UniProtKB/TrEMBL

D4A1L2

Related

ENSRNOP00000052978.5

Conserved Domains (7) summary

COG2319
Location:2436 → 2686

WD40; WD40 repeat [General function prediction only]

cd01201
Location:1916 → 2016

PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

pfam02138
Location:2039 → 2318

Beach; Beige/BEACH domain

pfam15787
Location:878 → 1127

DUF4704; Domain of unknown function (DUF4704)

pfam16057
Location:1593 → 1859

DUF4800; Domain of unknown function (DUF4800)

sd00039
Location:2436 → 2473

7WD40; WD40 repeat [structural motif]

cl02567
Location:2437 → 2686

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006244008.5 → XP_006244070.1 neurobeachin-like protein 2 isoform X1

See identical proteins and their annotated locations for XP_006244070.1

Conserved Domains (7) summary

COG2319
Location:2454 → 2704

WD40; WD40 repeat [General function prediction only]

cd01201
Location:1909 → 2034

PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

pfam02138
Location:2057 → 2336

Beach; Beige/BEACH domain

pfam15787
Location:871 → 1120

DUF4704; Domain of unknown function (DUF4704)

pfam16057
Location:1586 → 1852

DUF4800; Domain of unknown function (DUF4800)

sd00039
Location:2454 → 2491

7WD40; WD40 repeat [structural motif]

cl02567
Location:2455 → 2704

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039082643.2 → XP_038938571.1 neurobeachin-like protein 2 isoform X4

Conserved Domains (6) summary

smart01026
Location:2029 → 2309

Beach; Beige/BEACH domain

cd01201
Location:1882 → 2007

PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

sd00039
Location:2427 → 2464

7WD40; WD40 repeat [structural motif]

pfam15787
Location:844 → 1093

DUF4704; Domain of unknown function (DUF4704)

pfam16057
Location:1559 → 1825

DUF4800; Domain of unknown function (DUF4800)

cl29593
Location:2428 → 2677

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...