ZNF300 zinc finger protein 300 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF300provided by HGNC
Official Full Name: zinc finger protein 300provided by HGNC
Primary source: HGNC:HGNC:13091
See related: Ensembl:ENSG00000145908 MIM:612429; AllianceGenome:HGNC:13091
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Expression: Ubiquitous expression in ovary (RPKM 3.4), testis (RPKM 3.0) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 5q33.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (150894399..150904980, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (151430897..151441478, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (150273961..150284542, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cisplatin resistance and malignant behaviors of lung cancer cells are promoted by circ_0002360 via targeting miR-6751-3p to regulate the expression of ZNF300.
Title: Cisplatin resistance and malignant behaviors of lung cancer cells are promoted by circ_0002360 via targeting miR-6751-3p to regulate the expression of ZNF300.
ZNF300 promotes chemoresistance and aggressive behaviour in non-small-cell lung cancer.
Title: ZNF300 promotes chemoresistance and aggressive behaviour in non-small-cell lung cancer.
These results suggested that ZNF300 plays an important role in hepatic lipid metabolism via PPARalpha promoting fatty acid oxidation and this effect might be blocked by DNMT3a-mediated methylation of ZNF300.
Title: ZNF300 stimulates fatty acid oxidation and alleviates hepatosteatosis through regulating PPARα.
Our findings further support ZNF300P1 as frequently methylated in ovarian cancer and reveal a novel function for ZNF300P1 lincRNA expression
Title: ZNF300P1 encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer.
A novel function for ZNF300 in tumour development was identified that may uniquely link inflammation and NF-kappa B to tumourigenesis in humans but not in mice.
Title: Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathway.
Data show that co-expression of ZNF300 and Egr1 lead to enhanced IL-2Rbeta promoter activity, and suggest that ZNF300 is another regulator of the human IL-2Rbeta promoter.
Title: ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site.
ZNF300 was activated by PU.1 and suggested that the regulation may be involved in the progression of leukemia development and hematopoietic differentiation.
Title: PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide searching of rare genetic variants in WTCCC data.
Results show that the ZNF300 gene encodes a 68-kDa nuclear protein that binds DNA in a sequence-specific manner.
Title: Identification of the DNA binding element of the human ZNF300 protein.
ZNF-300 and novel splice variant ZNF300-B are both expressed highly in human testis.
Title: Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 300

Names: kruppel-like zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016866.1 RefSeqGene

Range

5004..15585

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001172831.3 → NP_001166302.1 zinc finger protein 300 isoform 1

Status: REVIEWED

Source sequence(s)

AC010441

Consensus CDS

CCDS54940.1

UniProtKB/Swiss-Prot

Q96RE9

Conserved Domains (6) summary

smart00349
Location:24 → 84

KRAB; krueppel associated box

COG5048
Location:258 → 616

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:483 → 503

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:481 → 503

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:24 → 63

KRAB; KRAB box

pfam13465
Location:327 → 352

zf-H2C2_2; Zinc-finger double domain
NM_001172832.3 → NP_001166303.1 zinc finger protein 300 isoform 3

Status: REVIEWED

Source sequence(s)

AC010441

Consensus CDS

CCDS54939.1

UniProtKB/Swiss-Prot

Q96RE9

Conserved Domains (5) summary

smart00349
Location:1 → 32

KRAB; krueppel associated box

COG5048
Location:206 → 564

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:431 → 451

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:429 → 451

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:275 → 300

zf-H2C2_2; Zinc-finger double domain
NM_052860.4 → NP_443092.1 zinc finger protein 300 isoform 2

See identical proteins and their annotated locations for NP_443092.1

Status: REVIEWED

Source sequence(s)

AC010441

Consensus CDS

CCDS4311.2

UniProtKB/Swiss-Prot

A8MY91, B3KU35, B4DU78, F5GWS1, Q06DQ3, Q17RP3, Q5H9N5, Q96RE9

Related

ENSP00000274599.5, ENST00000274599.10

Conserved Domains (3) summary

smart00349
Location:8 → 68

KRAB; krueppel associated box

COG5048
Location:294 → 590

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:467 → 487

ZF_C2H2; C2H2 Zn finger [structural motif]