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    Cep97 centrosomal protein 97 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304007, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Cep97provided by RGD
    Official Full Name
    centrosomal protein 97provided by RGD
    Primary source
    RGD:1307400
    See related
    Ensembl:ENSRNOG00000001609 AllianceGenome:RGD:1307400
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrriq2; RGD1307400
    Summary
    Predicted to be involved in negative regulation of cilium assembly and regulation of mitotic spindle assembly. Predicted to be located in centriolar satellite and cytosol. Predicted to be part of protein-containing complex. Orthologous to human CEP97 (centrosomal protein 97). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 69.1), Brain (RPKM 43.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep97 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (58152561..58187174)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (44683503..44711471)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (47146409..47174460)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 11 Neighboring gene zinc finger and BTB domain containing 11, opposite strand 1 Neighboring gene ribosomal protein L24 Neighboring gene uncharacterized LOC134481067 Neighboring gene neurexophilin and PC-esterase domain family, member 3 Neighboring gene adaptor related protein complex 3 subunit sigma 1, pseudogene 1 Neighboring gene NFKB inhibitor zeta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cep97 and CP110 suppress a cilia assembly program. Spektor A, et al. Cell, 2007 Aug 24. PMID 17719545
    2. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. Kobayashi T, et al. J Cell Biol, 2014 Jan 20. PMID 24421332, Free PMC Article
    3. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
    4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 97 kDa
    Names
    centrosomal protein 97kDa
    leucine-rich repeats and IQ motif containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107096.1 → NP_001100566.1  centrosomal protein of 97 kDa

      See identical proteins and their annotated locations for NP_001100566.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473967
      UniProtKB/TrEMBL
      A6IQR0, D4AC95
      Related
      ENSRNOP00000002191.2, ENSRNOT00000002191.5
      Conserved Domains (5) summary
      cd00116
      Location:21 → 126
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam14580
      Location:107 → 255
      LRR_9; Leucine-rich repeat
      sd00033
      Location:17 → 37
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:103 → 143
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:80 → 136
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      58152561..58187174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088372.2 → XP_038944300.1  centrosomal protein of 97 kDa isoform X3

      Conserved Domains (2) summary
      sd00033
      Location:17 → 37
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:18 → 242
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_039088373.2 → XP_038944301.1  centrosomal protein of 97 kDa isoform X4

      Conserved Domains (2) summary
      sd00033
      Location:17 → 37
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:18 → 242
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    3. XM_063270561.1 → XP_063126631.1  centrosomal protein of 97 kDa isoform X1

      UniProtKB/TrEMBL
      A6IQR3

    4. XM_006248250.4 → XP_006248312.1  centrosomal protein of 97 kDa isoform X2

      Conserved Domains (2) summary
      pfam14580
      Location:19 → 145
      LRR_9; Leucine-rich repeat
      sd00031
      Location:16 → 61
      LRR_1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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