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    gnb3b guanine nucleotide binding protein (G protein), beta polypeptide 3b [ Danio rerio (zebrafish) ]

    Gene ID: 406483, updated on 30-Mar-2024

    Summary

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    Official Symbol
    gnb3bprovided by ZNC
    Official Full Name
    guanine nucleotide binding protein (G protein), beta polypeptide 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2280
    See related
    Ensembl:ENSDARG00000002696 AllianceGenome:ZFIN:ZDB-GENE-040426-2280
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gnb3; zgc:73058; zgc:77780; wu:fk54b04
    Summary
    Predicted to enable signaling receptor complex adaptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in epiphysis; eye; pineal complex; retina; and retinal cone cell. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; familial hyperlipidemia; mental depression; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See gnb3b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (5106226..5125626, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (5189740..5209178, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene enolase 2 Neighboring gene triosephosphate isomerase 1a Neighboring gene si:dkey-89b17.4 Neighboring gene syntaxin 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation. Lagman D, et al. PLoS One, 2015. PMID 25806532, Free PMC Article
    2. Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. Lu Z, et al. Sci Rep, 2017 Apr 5. PMID 28378834, Free PMC Article
    3. Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity. Xu H, et al. Development, 2012 Jan. PMID 22096073, Free PMC Article
    4. Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish. Liu Y, et al. J Ophthalmol, 2015. PMID 26137319, Free PMC Article
    5. PRPF4 mutations cause autosomal dominant retinitis pigmentosa. Chen X, et al. Hum Mol Genet, 2014 Jun 1. PMID 24419317

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide binding protein (G protein), beta polypeptide 3b; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3b
    Names
    guanine nucleotide binding protein (G protein), beta polypeptide 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213202.1 → NP_998367.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3b

      See identical proteins and their annotated locations for NP_998367.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065866
      UniProtKB/TrEMBL
      Q6P025, Q6PC87
      Related
      ENSDARP00000005843.6, ENSDART00000005547.8
      Conserved Domains (3) summary
      COG2319
      Location:46 → 338
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:48 → 338
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:58 → 95
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      5106226..5125626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159345.4 → XP_005159402.1  guanine nucleotide binding protein (G protein), beta polypeptide 3b isoform X1

      See identical proteins and their annotated locations for XP_005159402.1

      UniProtKB/TrEMBL
      Q6P025, Q6PC87
      Related
      ENSDARP00000120734.2, ENSDART00000132642.4
      Conserved Domains (3) summary
      COG2319
      Location:46 → 338
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:48 → 338
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:58 → 95
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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