aspn asporin (LRR class 1) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aspnprovided by ZNC
Official Full Name: asporin (LRR class 1)provided by ZNC
Primary source: ZFIN:ZDB-GENE-041105-7
See related: Ensembl:ENSDARG00000002192 AllianceGenome:ZFIN:ZDB-GENE-041105-7
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bgl3; aspnl; wu:fk08c11; zgc:109936
Summary: Predicted to enable calcium ion binding activity and collagen binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in axial vasculature; chondrocranium; and pharyngeal arch. Human ortholog(s) of this gene implicated in ankylosing spondylitis; degenerative disc disease; and osteoarthritis. Orthologous to human ASPN (asporin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (10479965..10487511, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (10450283..10457829, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: asporin

Names: biglycan-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131713.2 → NP_571788.2 asporin precursor

Status: VALIDATED

Source sequence(s)

BC078368, EE689153, EE697401

UniProtKB/TrEMBL

A0A8M1P6K1, Q1LXA7

Related

ENSDARP00000064797.5, ENSDART00000064798.6

Conserved Domains (4) summary

smart00013
Location:64 → 94

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:133 → 323

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:74 → 93

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:97 → 152

LRR_8; Leucine rich repeat