NLRP5 NLR family pyrin domain containing 5 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: NLRP5provided by VGNC
Official Full Name: NLR family pyrin domain containing 5provided by VGNC
Primary source: VGNC:VGNC:43849
See related: Ensembl:ENSCAFG00845000354
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (102460071..102498949, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (101999948..102029018, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (102573033..102611882, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (102098621..102137465, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (101816356..101855182, complement)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

FH2774 (e-PCR)
- UniSTS:263648

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
part_of subcortical maternal complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051805.1 Reference ROS_Cfam_1.0

Range

102460071..102498949 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038653640.1 → XP_038509568.1 NACHT, LRR and PYD domains-containing protein 5 isoform X1

UniProtKB/TrEMBL

A0A8C0QA84, A0A8I3MAG7

Related

ENSCAFP00845000382.1, ENSCAFT00845000560.1

Conserved Domains (7) summary

cd08320
Location:81 → 164

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:891 → 918

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:976 → 1004

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:302 → 471

NACHT; NACHT domain

pfam17776
Location:607 → 723

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:549 → 605

NOD2_WH; NOD2 winged helix domain

cl39015
Location:799 → 1124

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049261.1 Alternate UMICH_Zoey_3.1

Range

102098621..102137465 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038468812.1 → XP_038324740.1 NACHT, LRR and PYD domains-containing protein 5 isoform X1

Conserved Domains (7) summary

cd08320
Location:81 → 164

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:891 → 918

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:976 → 1004

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:302 → 471

NACHT; NACHT domain

pfam17776
Location:607 → 723

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:549 → 605

NOD2_WH; NOD2 winged helix domain

cl39015
Location:799 → 1124

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049742.1 Alternate UNSW_CanFamBas_1.0

Range

101816356..101855182 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038589941.1 → XP_038445869.1 NACHT, LRR and PYD domains-containing protein 5 isoform X1

Conserved Domains (7) summary

cd08320
Location:81 → 164

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:891 → 918

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:976 → 1004

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:302 → 471

NACHT; NACHT domain

pfam17776
Location:607 → 723

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:549 → 605

NOD2_WH; NOD2 winged helix domain

cl39015
Location:799 → 1124

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049222.1 Alternate UU_Cfam_GSD_1.0

Range

102573033..102611882 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038525525.1 → XP_038381453.1 NACHT, LRR and PYD domains-containing protein 5 isoform X1

UniProtKB/TrEMBL

A0A8C0QA84, A0A8I3MAG7

Conserved Domains (7) summary

cd08320
Location:81 → 164

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:891 → 918

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:976 → 1004

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:302 → 471

NACHT; NACHT domain

pfam17776
Location:607 → 723

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:549 → 605

NOD2_WH; NOD2 winged helix domain

cl39015
Location:799 → 1124

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

101999948..102029018 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038459732.1 → XP_038315660.1 NACHT, LRR and PYD domains-containing protein 5 isoform X2

UniProtKB/TrEMBL

A0A8C0KNG3

Conserved Domains (7) summary

cd08320
Location:44 → 126

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:766 → 793

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:851 → 879

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:177 → 346

NACHT; NACHT domain

pfam17776
Location:482 → 598

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:424 → 480

NOD2_WH; NOD2 winged helix domain

cl39015
Location:674 → 999

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...