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    TRPV4 transient receptor potential cation channel subfamily V member 4 [ Canis lupus familiaris (dog) ]

    Gene ID: 486308, updated on 5-Mar-2024

    Summary

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    Gene symbol
    TRPV4
    Gene description
    transient receptor potential cation channel subfamily V member 4
    See related
    Ensembl:ENSCAFG00845022016
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See TRPV4 in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (17652672..17673399)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (18472505..18493002, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (17660529..17681097)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (18683516..18704163, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (17643537..17664298)

    Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene trichoplein keratin filament binding Neighboring gene glycolipid transfer protein Neighboring gene family with sequence similarity 222 member A Neighboring gene uncharacterized LOC119866184 Neighboring gene uncharacterized LOC111092709

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The amino-terminal domain of TRPV4 channel is involved in its trafficking to the nucleus. Méndez-Gómez S, et al. Biochem Biophys Res Commun, 2022 Feb 12. PMID 35007845
    2. Transient receptor potential V4 channel stimulation induces reversible epithelial cell permeability in MDCK cell monolayers. Mukaiyama M, et al. FEBS Lett, 2019 Aug. PMID 31206656
    3. TRPV4 activity regulates nuclear Ca(2+) and transcriptional functions of β-catenin in a renal epithelial cell model. Espadas-Álvarez H, et al. J Cell Physiol, 2021 May. PMID 33044004
    4. TRPP2 and TRPV4 form a polymodal sensory channel complex. Köttgen M, et al. J Cell Biol, 2008 Aug 11. PMID 18695040, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The amino-terminal domain of TRPV4 channel is involved in its trafficking to the nucleus.
      Title: The amino-terminal domain of TRPV4 channel is involved in its trafficking to the nucleus.
    2. TRPV4 activity regulates nuclear Ca(2+) and transcriptional functions of beta-catenin in a renal epithelial cell model.
      Title: TRPV4 activity regulates nuclear Ca(2+) and transcriptional functions of β-catenin in a renal epithelial cell model.
    3. Results have shown that TRPV4 activation induces Ca2+ influx, resulting in the reversible opening of tight junctions.
      Title: Transient receptor potential V4 channel stimulation induces reversible epithelial cell permeability in MDCK cell monolayers.
    4. TRPP2 utilizes TRPV4 to form a mechano- and thermosensitive molecular sensor in the cilium.
      Title: TRPP2 and TRPV4 form a polymodal sensory channel complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in osmosensory signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily V member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127315.1 → NP_001120787.1  transient receptor potential cation channel subfamily V member 4

      See identical proteins and their annotated locations for NP_001120787.1

      Status: PROVISIONAL

      Source sequence(s)
      EF561643
      UniProtKB/TrEMBL
      A0A8C0LBA3, A0A8C0TND6, B2KN54
      Related
      ENSCAFP00845031013.1, ENSCAFT00845039580.1
      Conserved Domains (2) summary
      sd00045
      Location:237 → 268
      ANK; ANK repeat [structural motif]
      cl26777
      Location:149 → 803
      TRP_2; Transient receptor ion channel II

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051830.1 Reference ROS_Cfam_1.0

      Range
      17652672..17673399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049286.1 Alternate UMICH_Zoey_3.1

      Range
      18683516..18704163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

      Range
      17643537..17664298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

      Range
      17660529..17681097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      18472505..18493002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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