CAVIN2 caveolae associated protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CAVIN2provided by HGNC
Official Full Name: caveolae associated protein 2provided by HGNC
Primary source: HGNC:HGNC:10690
See related: Ensembl:ENSG00000168497 MIM:606728; AllianceGenome:HGNC:10690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SDR; SDPR; PS-p68; cavin-2
Summary: This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]
Expression: Broad expression in fat (RPKM 116.9), lung (RPKM 67.0) and 17 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2q32.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (191834310..191847088, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (192322523..192335302, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (192699036..192711814, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC00261/microRNA-550a-3p/SDPR axis affects the biological characteristics of breast cancer stem cells.
Title: LINC00261/microRNA-550a-3p/SDPR axis affects the biological characteristics of breast cancer stem cells.
Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways.
Title: Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways.
CAVIN2 is frequently silenced by CpG methylation and sensitizes lung cancer cells to paclitaxel and 5-FU.
Title: CAVIN2 is frequently silenced by CpG methylation and sensitizes lung cancer cells to paclitaxel and 5-FU.
Serum deprivation response functions as a tumor suppressor gene in papillary thyroid cancer.
Title: Serum deprivation response functions as a tumor suppressor gene in papillary thyroid cancer.
Low SDPR expression is associated with cancer.
Title: A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer.
Long non-coding RNA SDPR-AS affects the development of non-small cell lung cancer by regulating SDPR through p38 MAPK/ERK signals
Title: Long non-coding RNA SDPR-AS affects the development of non-small cell lung cancer by regulating SDPR through p38 MAPK/ERK signals.
Results show that SDPR expression is increased in invasive endometrioid carcinoma (EC) and provide evidence that SDPR protein alter the expression of ALDH1 in EC cells through ILK signaling. Moreover, SDPR is associated with several histological characteristics of invasiveness.
Title: Serum deprivation-response protein regulates aldehyde dehydrogenase 1 through integrin-linked kinase signaling in endometrioid carcinoma cells.
SDPR variants were not associated with major depressive disorder.
Title: PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder.
Overall, these data suggest that Cavin-2 represents a useful marker for discriminating the degree of differentiation in LPS tumors.
Title: Cavin-2 is a specific marker for detection of well-differentiated liposarcoma.
Data found that CVN2 expression was signi fi cantly down-regulated in oral squamous cell carcinoma (OSCC) in vitro and in vivo and that CVN2 overexpression led to decreased proliferative activities through the CVN2/caveolin-1/ERK path- way. Furthermore, high tumoral progression occurred in CVN2-negative patients with OSCC.
Title: Cavin-2 in oral cancer: A potential predictor for tumor progression.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH66552 (e-PCR)
- UniSTS:14890

RH45862 (e-PCR)
- UniSTS:18743

A004T07 (e-PCR)
- UniSTS:589

WI-12497 (e-PCR)
- UniSTS:76496

SGC38126 (e-PCR)
- UniSTS:55028

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in plasma membrane tubulation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

Go to the top of the page Help

Preferred Names: caveolae-associated protein 2

Names: phosphatidylserine-binding protein; serum deprivation response; serum deprivation-response protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.