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    tnsl-1 Tonsoku-like protein [ Caenorhabditis elegans ]

    Gene ID: 172642, updated on 12-Jun-2024

    Summary

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    Gene symbol
    tnsl-1
    Gene description
    Tonsoku-like protein
    Locus tag
    CELE_K02B12.5
    See related
    AllianceGenome:WB:WBGene00010498
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Sponastrime type. Orthologous to human TONSL (tonsoku like, DNA repair protein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See tnsl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    22
    Sequence:
    Chromosome: I; NC_003279.8 (8517453..8526621, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Myb_DNA-bind_3 domain-containing protein Neighboring gene Axin-like protein 1 Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene ncRNA Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Arf-GAP domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene Zip homologous protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    Tonsoku-like protein
    NP_001361839.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8517453..8526621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001374927.3 → NP_001361839.1  Tonsoku-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21117
      Conserved Domains (3) summary
      sd00033
      Location:970 → 989
      LRR_RI; leucine-rich repeat [structural motif]
      sd00045
      Location:515 → 546
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:519 → 629
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version

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