MDC1 mediator of DNA damage checkpoint 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MDC1provided by HGNC
Official Full Name: mediator of DNA damage checkpoint 1provided by HGNC
Primary source: HGNC:HGNC:21163
See related: Ensembl:ENSG00000137337 MIM:607593; AllianceGenome:HGNC:21163
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NFBD1
Summary: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 20.6), thyroid (RPKM 7.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.33

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (30699807..30717281, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (30564011..30584416, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (30667584..30685058, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease.
Title: Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease.
A positive feedback loop between ID3 and PPARgamma via DNA damage repair regulates the efficacy of radiotherapy for rectal cancer.
Title: A positive feedback loop between ID3 and PPARγ via DNA damage repair regulates the efficacy of radiotherapy for rectal cancer.
MDC1 maintains active elongation complexes of RNA polymerase II.
Title: MDC1 maintains active elongation complexes of RNA polymerase II.
Targeting MDC1 promotes apoptosis and sensitizes Imatinib resistance in CML cells by mainly disrupting non-homologous end-joining repair.
Title: Targeting MDC1 promotes apoptosis and sensitizes Imatinib resistance in CML cells by mainly disrupting non-homologous end-joining repair.
Loss of ID3 in pancreatic cancer cells increases DNA damage without impairing MDC1 recruitment to the nuclear foci.
Title: Loss of ID3 in pancreatic cancer cells increases DNA damage without impairing MDC1 recruitment to the nuclear foci.
Functional defects of cancer-associated MDC1 mutations in DNA damage repair.
Title: Functional defects of cancer-associated MDC1 mutations in DNA damage repair.
Mediator of DNA Damage Checkpoint 1 (MDC1) Is a Novel Estrogen Receptor Coregulator in Invasive Lobular Carcinoma of the Breast.
Title: Mediator of DNA Damage Checkpoint 1 (MDC1) Is a Novel Estrogen Receptor Coregulator in Invasive Lobular Carcinoma of the Breast.
Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study.
Title: Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study.
MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells.
Title: MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells.
MDC1 plays a role in tumorigenesis of oral squamous cell carcinoma
Title: Effect of silencing of mediator of DNA damage checkpoint protein 1 on the growth of oral squamous cell carcinoma in vitro and in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (101)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH36324 (e-PCR)
- UniSTS:31510

RH25387 (e-PCR)
- UniSTS:12643

SHGC-170044 (e-PCR)
- UniSTS:173709

WI-15445 (e-PCR)
- UniSTS:81329

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chromatin-protein adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables histone reader activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication checkpoint signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic intra-S DNA damage checkpoint signaling	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to site of double-strand break	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	IDA Inferred from Direct Assay more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in site of double-strand break	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mediator of DNA damage checkpoint protein 1

Names: homologue to Drosophila photoreceptor protein calphotin; nuclear factor with BRCT domains 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014641.3 → NP_055456.2 mediator of DNA damage checkpoint protein 1

See identical proteins and their annotated locations for NP_055456.2

Status: REVIEWED

Source sequence(s)

AL662797, BU621433, D79992, EF177823

Consensus CDS

CCDS34384.1

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBB2, A0A1U9XBC1

Related

ENSP00000365588.3, ENST00000376406.8

Conserved Domains (5) summary

pfam00498
Location:55 → 110

FHA; FHA domain

cl00038
Location:1882 → 1968

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

cl25732
Location:822 → 962

SMC_N; RecF/RecN/SMC N terminal domain

cl25751
Location:943 → 1376

DUF4045; Domain of unknown function (DUF4045)

cl26464
Location:1227 → 1757

Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

30699807..30717281 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047419589.1 → XP_047275545.1 mediator of DNA damage checkpoint protein 1 isoform X11
XM_047419588.1 → XP_047275544.1 mediator of DNA damage checkpoint protein 1 isoform X10
XM_047419586.1 → XP_047275542.1 mediator of DNA damage checkpoint protein 1 isoform X7
XM_005249494.6 → XP_005249551.1 mediator of DNA damage checkpoint protein 1 isoform X3

See identical proteins and their annotated locations for XP_005249551.1

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBB2, A0A1U9XBC1

Conserved Domains (5) summary

pfam00498
Location:55 → 110

FHA; FHA domain

cl00038
Location:1882 → 1968

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

cl25732
Location:822 → 962

SMC_N; RecF/RecN/SMC N terminal domain

cl25751
Location:943 → 1376

DUF4045; Domain of unknown function (DUF4045)

cl26464
Location:1227 → 1757

Atrophin-1; Atrophin-1 family
XM_047419582.1 → XP_047275538.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_047419584.1 → XP_047275540.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_017011522.3 → XP_016867011.1 mediator of DNA damage checkpoint protein 1 isoform X9

UniProtKB/TrEMBL

B4DYH4
XM_047419585.1 → XP_047275541.1 mediator of DNA damage checkpoint protein 1 isoform X6
XM_047419581.1 → XP_047275537.1 mediator of DNA damage checkpoint protein 1 isoform X2
XM_047419587.1 → XP_047275543.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_047419580.1 → XP_047275536.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_047419583.1 → XP_047275539.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_011515003.4 → XP_011513305.1 mediator of DNA damage checkpoint protein 1 isoform X3

See identical proteins and their annotated locations for XP_011513305.1

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBB2, A0A1U9XBC1

Conserved Domains (5) summary

pfam00498
Location:55 → 110

FHA; FHA domain

cl00038
Location:1882 → 1968

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

cl25732
Location:822 → 962

SMC_N; RecF/RecN/SMC N terminal domain

cl25751
Location:943 → 1376

DUF4045; Domain of unknown function (DUF4045)

cl26464
Location:1227 → 1757

Atrophin-1; Atrophin-1 family
XM_005249498.5 → XP_005249555.1 mediator of DNA damage checkpoint protein 1 isoform X8

See identical proteins and their annotated locations for XP_005249555.1

UniProtKB/TrEMBL

B4DYH4

Conserved Domains (2) summary

cd00027
Location:1663 → 1715

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

pfam00498
Location:76 → 144

FHA; FHA domain
XM_005249497.5 → XP_005249554.1 mediator of DNA damage checkpoint protein 1 isoform X5

See identical proteins and their annotated locations for XP_005249554.1

UniProtKB/TrEMBL

A0A1U9XBB2

Conserved Domains (2) summary

cd00027
Location:1737 → 1789

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

pfam00498
Location:76 → 144

FHA; FHA domain
XM_005249492.3 → XP_005249549.1 mediator of DNA damage checkpoint protein 1 isoform X1

See identical proteins and their annotated locations for XP_005249549.1

UniProtKB/TrEMBL

A0A1U9XBB2

Conserved Domains (6) summary

PTZ00449
Location:964 → 1397

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03247
Location:1248 → 1778

PHA03247; large tegument protein UL36; Provisional

cd00060
Location:54 → 144

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

TIGR02169
Location:843 → 983

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

cd17744
Location:1914 → 1984

BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins

cd18441
Location:2016 → 2096

BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
XM_011515004.4 → XP_011513306.1 mediator of DNA damage checkpoint protein 1 isoform X4

See identical proteins and their annotated locations for XP_011513306.1

UniProtKB/TrEMBL

A0A1U9XBB2

Conserved Domains (1) summary

cd00027
Location:1778 → 1830

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

2029312..2047039 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328530.1 → XP_054184505.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054328540.1 → XP_054184515.1 mediator of DNA damage checkpoint protein 1 isoform X11
XM_054328539.1 → XP_054184514.1 mediator of DNA damage checkpoint protein 1 isoform X10
XM_054328531.1 → XP_054184506.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054328533.1 → XP_054184508.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054328538.1 → XP_054184513.1 mediator of DNA damage checkpoint protein 1 isoform X9
XM_054328536.1 → XP_054184511.1 mediator of DNA damage checkpoint protein 1 isoform X6
XM_054328529.1 → XP_054184504.1 mediator of DNA damage checkpoint protein 1 isoform X2
XM_054328537.1 → XP_054184512.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054328535.1 → XP_054184510.1 mediator of DNA damage checkpoint protein 1 isoform X5
XM_054328527.1 → XP_054184502.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054328532.1 → XP_054184507.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054328528.1 → XP_054184503.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054328534.1 → XP_054184509.1 mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

Range

2179547..2198636 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329934.1 → XP_054185909.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054329941.1 → XP_054185916.1 mediator of DNA damage checkpoint protein 1 isoform X7
XM_054329946.1 → XP_054185921.1 mediator of DNA damage checkpoint protein 1 isoform X11
XM_054329945.1 → XP_054185920.1 mediator of DNA damage checkpoint protein 1 isoform X10
XM_054329935.1 → XP_054185910.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054329937.1 → XP_054185912.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054329944.1 → XP_054185919.1 mediator of DNA damage checkpoint protein 1 isoform X9
XM_054329940.1 → XP_054185915.1 mediator of DNA damage checkpoint protein 1 isoform X6
XM_054329933.1 → XP_054185908.1 mediator of DNA damage checkpoint protein 1 isoform X2
XM_054329942.1 → XP_054185917.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054329939.1 → XP_054185914.1 mediator of DNA damage checkpoint protein 1 isoform X5
XM_054329931.1 → XP_054185906.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054329943.1 → XP_054185918.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054329936.1 → XP_054185911.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054329932.1 → XP_054185907.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054329938.1 → XP_054185913.1 mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

Range

1955659..1974752 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330428.1 → XP_054186403.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330439.1 → XP_054186414.1 mediator of DNA damage checkpoint protein 1 isoform X11
XM_054330438.1 → XP_054186413.1 mediator of DNA damage checkpoint protein 1 isoform X10
XM_054330429.1 → XP_054186404.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330431.1 → XP_054186406.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330437.1 → XP_054186412.1 mediator of DNA damage checkpoint protein 1 isoform X9
XM_054330434.1 → XP_054186409.1 mediator of DNA damage checkpoint protein 1 isoform X6
XM_054330426.1 → XP_054186401.1 mediator of DNA damage checkpoint protein 1 isoform X2
XM_054330435.1 → XP_054186410.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054330433.1 → XP_054186408.1 mediator of DNA damage checkpoint protein 1 isoform X5
XM_054330424.1 → XP_054186399.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054330427.1 → XP_054186402.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330430.1 → XP_054186405.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330425.1 → XP_054186400.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054330436.1 → XP_054186411.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054330432.1 → XP_054186407.1 mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

Range

2010059..2030465 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330696.1 → XP_054186671.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330702.1 → XP_054186677.1 mediator of DNA damage checkpoint protein 1 isoform X7
XM_054330704.1 → XP_054186679.1 mediator of DNA damage checkpoint protein 1 isoform X11
XM_054330703.1 → XP_054186678.1 mediator of DNA damage checkpoint protein 1 isoform X10
XM_054330697.1 → XP_054186672.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330699.1 → XP_054186674.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330698.1 → XP_054186673.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330701.1 → XP_054186676.1 mediator of DNA damage checkpoint protein 1 isoform X13
XM_054330695.1 → XP_054186670.1 mediator of DNA damage checkpoint protein 1 isoform X12
XM_054330700.1 → XP_054186675.1 mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

Range

2043883..2064289 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330922.1 → XP_054186897.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330928.1 → XP_054186903.1 mediator of DNA damage checkpoint protein 1 isoform X7
XM_054330933.1 → XP_054186908.1 mediator of DNA damage checkpoint protein 1 isoform X11
XM_054330932.1 → XP_054186907.1 mediator of DNA damage checkpoint protein 1 isoform X10
XM_054330921.1 → XP_054186896.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330924.1 → XP_054186899.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330931.1 → XP_054186906.1 mediator of DNA damage checkpoint protein 1 isoform X9
XM_054330927.1 → XP_054186902.1 mediator of DNA damage checkpoint protein 1 isoform X6
XM_054330919.1 → XP_054186894.1 mediator of DNA damage checkpoint protein 1 isoform X2
XM_054330929.1 → XP_054186904.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054330926.1 → XP_054186901.1 mediator of DNA damage checkpoint protein 1 isoform X5
XM_054330917.1 → XP_054186892.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054330930.1 → XP_054186905.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054330920.1 → XP_054186895.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330923.1 → XP_054186898.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054330918.1 → XP_054186893.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054330925.1 → XP_054186900.1 mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

Range

1954920..1972647 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331201.1 → XP_054187176.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/TrEMBL

A0A1U9XBE3
XM_054331208.1 → XP_054187183.1 mediator of DNA damage checkpoint protein 1 isoform X7
XM_054331212.1 → XP_054187187.1 mediator of DNA damage checkpoint protein 1 isoform X11
XM_054331211.1 → XP_054187186.1 mediator of DNA damage checkpoint protein 1 isoform X10
XM_054331202.1 → XP_054187177.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/TrEMBL

A0A1U9XBE3
XM_054331204.1 → XP_054187179.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/TrEMBL

A0A1U9XBE3
XM_054331210.1 → XP_054187185.1 mediator of DNA damage checkpoint protein 1 isoform X9
XM_054331209.1 → XP_054187184.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054331198.1 → XP_054187173.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054331203.1 → XP_054187178.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/TrEMBL

A0A1U9XBE3
XM_054331200.1 → XP_054187175.1 mediator of DNA damage checkpoint protein 1 isoform X2
XM_054331199.1 → XP_054187174.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054331207.1 → XP_054187182.1 mediator of DNA damage checkpoint protein 1 isoform X6
XM_054331206.1 → XP_054187181.1 mediator of DNA damage checkpoint protein 1 isoform X5
XM_054331205.1 → XP_054187180.1 mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

Range

2000593..2019687 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331438.1 → XP_054187413.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/TrEMBL

A0A1U9XBF2
XM_054331439.1 → XP_054187414.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/TrEMBL

A0A1U9XBF2
XM_054331447.1 → XP_054187422.1 mediator of DNA damage checkpoint protein 1 isoform X9
XM_054331444.1 → XP_054187419.1 mediator of DNA damage checkpoint protein 1 isoform X6
XM_054331437.1 → XP_054187412.1 mediator of DNA damage checkpoint protein 1 isoform X2
XM_054331445.1 → XP_054187420.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054331443.1 → XP_054187418.1 mediator of DNA damage checkpoint protein 1 isoform X5
XM_054331436.1 → XP_054187411.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054331440.1 → XP_054187415.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/TrEMBL

A0A1U9XBF2
XM_054331446.1 → XP_054187421.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054331441.1 → XP_054187416.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/TrEMBL

A0A1U9XBF2
XM_054331442.1 → XP_054187417.1 mediator of DNA damage checkpoint protein 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

30564011..30584416 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054356869.1 → XP_054212844.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054356875.1 → XP_054212850.1 mediator of DNA damage checkpoint protein 1 isoform X7
XM_054356880.1 → XP_054212855.1 mediator of DNA damage checkpoint protein 1 isoform X11
XM_054356879.1 → XP_054212854.1 mediator of DNA damage checkpoint protein 1 isoform X10
XM_054356868.1 → XP_054212843.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054356871.1 → XP_054212846.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054356878.1 → XP_054212853.1 mediator of DNA damage checkpoint protein 1 isoform X9
XM_054356874.1 → XP_054212849.1 mediator of DNA damage checkpoint protein 1 isoform X6
XM_054356867.1 → XP_054212842.1 mediator of DNA damage checkpoint protein 1 isoform X2
XM_054356876.1 → XP_054212851.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054356873.1 → XP_054212848.1 mediator of DNA damage checkpoint protein 1 isoform X5
XM_054356865.1 → XP_054212840.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054356877.1 → XP_054212852.1 mediator of DNA damage checkpoint protein 1 isoform X8
XM_054356870.1 → XP_054212845.1 mediator of DNA damage checkpoint protein 1 isoform X3

UniProtKB/Swiss-Prot

A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2

UniProtKB/TrEMBL

A0A1U9XBC1
XM_054356866.1 → XP_054212841.1 mediator of DNA damage checkpoint protein 1 isoform X1
XM_054356872.1 → XP_054212847.1 mediator of DNA damage checkpoint protein 1 isoform X4