Fat3 FAT atypical cadherin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fat3provided by MGI
Official Full Name: FAT atypical cadherin 3provided by MGI
Primary source: MGI:MGI:2444314
See related: Ensembl:ENSMUSG00000074505 AllianceGenome:MGI:2444314
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm510; Gm1132; MFAT3F; 9430076A06Rik; D430038H04Rik
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including negative regulation of dendrite development; neuron migration; and retina layer formation. Located in dendrite. Is expressed in several structures, including brain; ganglia; inner ear; retina; and skeleton. Orthologous to human FAT3 (FAT atypical cadherin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 3.7), frontal lobe adult (RPKM 3.2) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A2; 9 5.16 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (15821485..16413981, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (15910189..16502681, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development.
Title: A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development.
Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly.
Title: Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly.
Fat cadherins in mouse models of degenerative ataxias.
Title: Fat cadherins in mouse models of degenerative ataxias.
Fat3 functions cell-autonomously and is able to influence the cytoskeleton directly through its intracellular domain, which can bind and localize Ena/VASP family actin regulators.
Title: Fat3 and Ena/VASP proteins influence the emergence of asymmetric cell morphology in the developing retina.
Data find that during mouse development, Fat3 and Fat4 synergize to drive vertebral arch fusion at the dorsal midline during caudal vertebra morphogenesis.
Title: Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.
This study demonistrated that fat3 mutation in thr mice caused amacrine cell migration and retina development.
Title: Control of neuronal morphology by the atypical cadherin Fat3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548523

Fat3 (e-PCR), detects polymorphism
- UniSTS:478933

NoName (e-PCR)
- UniSTS:224222

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interneuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina layer formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protocadherin Fat 3

Names: FAT tumor suppressor homolog 3; protocadherin Fat3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080814.2 → NP_001074283.2 protocadherin Fat 3 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC154406, AC154741, AC159817, AC161370, AC162903

Consensus CDS

CCDS40539.2

UniProtKB/Swiss-Prot

Q08ED4, Q8BNA6

UniProtKB/TrEMBL

E9QK16

Related

ENSMUSP00000080808.6, ENSMUST00000082170.6

Conserved Domains (4) summary

cd11304
Location:1048 → 1143

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:285 → 372

CA; Cadherin repeats

cd00054
Location:4097 → 4132

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02210
Location:3864 → 3992

Laminin_G_2; Laminin G domain
NM_001413471.1 → NP_001400400.1 protocadherin Fat 3 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC154406, AC154741, AC159817, AC161370, AC162903

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

15821485..16413981 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242542.4 → XP_011240844.1 protocadherin Fat 3 isoform X5

UniProtKB/TrEMBL

E9QK16

Conserved Domains (4) summary

cd11304
Location:1049 → 1144

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:286 → 373

CA; Cadherin repeats

cd00054
Location:4121 → 4156

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02210
Location:3888 → 4014

Laminin_G_2; Laminin G domain
XM_011242541.4 → XP_011240843.1 protocadherin Fat 3 isoform X3

UniProtKB/TrEMBL

E9QK16

Conserved Domains (4) summary

cd11304
Location:1049 → 1144

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:286 → 373

CA; Cadherin repeats

cd00054
Location:4121 → 4156

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02210
Location:3888 → 4014

Laminin_G_2; Laminin G domain
XM_017313398.3 → XP_017168887.1 protocadherin Fat 3 isoform X2

UniProtKB/TrEMBL

E9QK16

Conserved Domains (4) summary

cd11304
Location:1049 → 1144

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:286 → 373

CA; Cadherin repeats

cd00054
Location:4121 → 4156

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02210
Location:3888 → 4014

Laminin_G_2; Laminin G domain
XM_011242543.4 → XP_011240845.1 protocadherin Fat 3 isoform X1

UniProtKB/TrEMBL

E9QK16

Conserved Domains (4) summary

cd11304
Location:1049 → 1144

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:286 → 373

CA; Cadherin repeats

cd00054
Location:4121 → 4156

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02210
Location:3888 → 4014

Laminin_G_2; Laminin G domain
XM_030244399.2 → XP_030100259.1 protocadherin Fat 3 isoform X6

Conserved Domains (3) summary

cd11304
Location:2107 → 2203

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:2964 → 2999

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02210
Location:2731 → 2857

Laminin_G_2; Laminin G domain
XM_036155026.1 → XP_036010919.1 protocadherin Fat 3 isoform X7

Conserved Domains (2) summary

cd11304
Location:1049 → 1144

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:286 → 373

CA; Cadherin repeats
XM_036155027.1 → XP_036010920.1 protocadherin Fat 3 isoform X8

Conserved Domains (2) summary

cd11304
Location:1049 → 1144

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:286 → 373

CA; Cadherin repeats