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    teq Tequila [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39048, updated on 10-May-2024

    Summary

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    Official Symbol
    teqprovided by FlyBase
    Official Full Name
    Tequilaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023479
    Locus tag
    Dmel_CG4821
    See related
    AllianceGenome:FB:FBgn0023479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:ParkEST161; BEST:CK00198; BEST:GH18038; CG18153; CG18403; CG4821; CG4948; CK00198; Dmel\CG4821; graal; SP72; Teq
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in glucose homeostasis; memory; and positive regulation of insulin secretion. Predicted to be located in extracellular region and membrane. Is expressed in adult brain; adult head; dorsal anterior lateral neuron of the protocerebrum; and eye. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human PRSS12 (serine protease 12). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    66F4-66F5; 3-28 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9074643..9092131)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9067743..9085231)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comment on "Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila". Sonderegger P, et al. Science, 2007 Jun 22. PMID 17588915
    2. Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains. Bikker FJ, et al. J Biol Chem, 2004 Nov 12. PMID 15355985
    3. Tequila Regulates Insulin-Like Signaling and Extends Life Span in Drosophila melanogaster. Huang CW, et al. J Gerontol A Biol Sci Med Sci, 2015 Dec. PMID 26265729, Free PMC Article
    4. To favor survival under food shortage, the brain disables costly memory. Plaçais PY, et al. Science, 2013 Jan 25. PMID 23349289
    5. Parametric and genetic analysis of Drosophila appetitive long-term memory and sugar motivation. Colomb J, et al. Genes Brain Behav, 2009 Jun. PMID 19220480

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 9076982-9084484 mobile_element_type = transposon:412{}teq[iso-1]

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in short-term memory IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tequila
    Names
    CG4821-PC
    CG4821-PD
    CG4821-PF
    CG4821-PG
    teq-PC
    teq-PD
    teq-PF
    teq-PG
    NP_001163393.2
    • unusual splice
    NP_648288.2
    • unusual splice
    NP_729451.1
    NP_729452.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9074643..9092131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140031.3 → NP_648288.2  tequila, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648288.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960G6, Q9VSU1, Q9VSU2
      Conserved Domains (9) summary
      smart00192
      Location:2337 → 2370
      LDLa; Low-density lipoprotein receptor domain class A
      smart00020
      Location:2546 → 2781
      Tryp_SPc; Trypsin-like serine protease
      smart00202
      Location:2382 → 2480
      SR; Scavenger receptor Cys-rich
      smart00494
      Location:136 → 184
      ChtBD2; Chitin-binding domain type 2
      cd00112
      Location:2193 → 2222
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:2547 → 2784
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00530
      Location:2386 → 2480
      SRCR; Scavenger receptor cysteine-rich domain
      pfam01607
      Location:65 → 115
      CBM_14; Chitin binding Peritrophin-A domain
      cl23782
      Location:1051 → 1126
      RCR; Chitin synthesis regulation, resistance to Congo red

    2. NM_001169922.3 → NP_001163393.2  tequila, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163393.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI93, Q9BI19
      Conserved Domains (9) summary
      smart00192
      Location:1924 → 1957
      LDLa; Low-density lipoprotein receptor domain class A
      smart00020
      Location:2133 → 2368
      Tryp_SPc; Trypsin-like serine protease
      smart00202
      Location:1969 → 2067
      SR; Scavenger receptor Cys-rich
      smart00494
      Location:136 → 184
      ChtBD2; Chitin-binding domain type 2
      cd00112
      Location:1780 → 1809
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:2134 → 2371
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00530
      Location:1973 → 2067
      SRCR; Scavenger receptor cysteine-rich domain
      pfam01607
      Location:65 → 115
      CBM_14; Chitin binding Peritrophin-A domain
      cl23782
      Location:1038 → 1126
      RCR; Chitin synthesis regulation, resistance to Congo red

    3. NM_168314.3 → NP_729451.1  tequila, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729451.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQB8, Q9U1I2
      Related
      FBpp0076252
      Conserved Domains (8) summary
      smart00192
      Location:995 → 1028
      LDLa; Low-density lipoprotein receptor domain class A
      smart00020
      Location:1204 → 1439
      Tryp_SPc; Trypsin-like serine protease
      smart00202
      Location:1040 → 1138
      SR; Scavenger receptor Cys-rich
      smart00494
      Location:136 → 184
      ChtBD2; Chitin-binding domain type 2
      cd00112
      Location:851 → 880
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:1205 → 1442
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00530
      Location:1044 → 1138
      SRCR; Scavenger receptor cysteine-rich domain
      pfam01607
      Location:65 → 115
      CBM_14; Chitin binding Peritrophin-A domain

    4. NM_168315.3 → NP_729452.1  tequila, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729452.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPA5, Q9VST9
      Related
      FBpp0076254
      Conserved Domains (2) summary
      smart00494
      Location:136 → 184
      ChtBD2; Chitin-binding domain type 2
      pfam01607
      Location:65 → 115
      CBM_14; Chitin binding Peritrophin-A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JI93 E1JI93
    O45029 O45029
    Q8IQB8 Q8IQB8
    Q8MRY3 Q8MRY3
    Q8T0I5 Q8T0I5
    Q960G6 Q960G6
    Q9BI19 Q9BI19
    Q9U1I2 Q9U1I2
    Q9U1I3 Q9U1I3
    Q9VST9 Q9VST9
    Q9VSU2 Q9VSU2

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