Chadl chondroadherin-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Chadlprovided by RGD
Full Name: chondroadherin-likeprovided by RGD
Primary source: RGD:6504353
See related: Ensembl:ENSRNOG00000024631 AllianceGenome:RGD:6504353
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable collagen binding activity and collagen fibril binding activity. Predicted to be involved in negative regulation of chondrocyte differentiation and negative regulation of collagen fibril organization. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human CHADL (chondroadherin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 14.6), Lung (RPKM 13.8) and 9 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (115085447..115097565, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (113205323..113218678, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (122915847..122929127, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen fibril binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen fibril organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_063264686.1 → XP_063120756.1 chondroadherin-like protein isoform X2
XM_063264685.1 → XP_063120755.1 chondroadherin-like protein isoform X1

UniProtKB/TrEMBL

F1LVK3
XM_063264684.1 → XP_063120754.1 chondroadherin-like protein isoform X1

UniProtKB/TrEMBL

F1LVK3
XM_008765809.4 → XP_008764031.1 chondroadherin-like protein isoform X1

See identical proteins and their annotated locations for XP_008764031.1

UniProtKB/TrEMBL

A6HT11, F1LVK3

Related

ENSRNOP00000000205.6

Conserved Domains (6) summary

smart00013
Location:27 → 59

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:663 → 711

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:381 → 617

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:656 → 667

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:58 → 81

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:437 → 497

LRR_8; Leucine rich repeat