Abcb9 ATP binding cassette subfamily B member 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcb9provided by RGD
Official Full Name: ATP binding cassette subfamily B member 9provided by RGD
Primary source: RGD:620254
See related: Ensembl:ENSRNOG00000001082 AllianceGenome:RGD:620254
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tapl
Summary: Predicted to enable several functions, including ABC-type peptide transporter activity; ATP binding activity; and TAP1 binding activity. Predicted to contribute to MHC class I protein binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I; peptide metabolic process; and peptide transport. Predicted to be located in endoplasmic reticulum membrane and lysosomal membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of MHC class I peptide loading complex. Predicted to be integral component of membrane. Orthologous to human ABCB9 (ATP binding cassette subfamily B member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 60.2), Muscle (RPKM 37.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q15

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (38146659..38192862)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (32499213..32531932)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (37923974..37956678)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type oligopeptide transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type oligopeptide transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type peptide transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type peptide transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in antigen processing and presentation of peptide antigen via MHC class I	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in oligopeptide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in peptide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptide transport	IEA Inferred from Electronic Annotation more info
involved_in peptide transport	ISO Inferred from Sequence Orthology more info
involved_in peptide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ATP-binding cassette (ABC) transporter complex	TAS Traceable Author Statement more info	PubMed
NOT located_in early endosome	ISO Inferred from Sequence Orthology more info
NOT located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ABC-type oligopeptide transporter ABCB9

Names: ABC transporter 9 protein; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ATP-binding cassette, sub-family B (MDR/TAP), member 9; ATP-binding cassette, subfamily B (MDR/TAP), member 9; TAP-like ABC transporter; TAP-like protein

NP_071574.1

EC 7.4.2.6

XP_038945646.1

EC 7.4.2.6

XP_063127680.1

EC 7.4.2.6

XP_063127681.1

EC 7.4.2.6

XP_063127682.1

EC 7.4.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022238.3 → NP_071574.1 ABC-type oligopeptide transporter ABCB9

See identical proteins and their annotated locations for NP_071574.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q764Q5, Q764Q6, Q9QYJ4

UniProtKB/TrEMBL

A0A0A0MY39, A6J117

Related

ENSRNOP00000096168.1, ENSRNOT00000098844.1

Conserved Domains (3) summary

cd03248
Location:489 → 714

ABCC_TAP; ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C

TIGR00958
Location:44 → 734

3a01208; Conjugate Transporter-2 (CT2) Family protein

pfam00664
Location:189 → 451

ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

38146659..38192862

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271610.1 → XP_063127680.1 ABC-type oligopeptide transporter ABCB9 isoform X1

UniProtKB/Swiss-Prot

Q764Q5, Q764Q6, Q9QYJ4

UniProtKB/TrEMBL

A6J117
XM_063271612.1 → XP_063127682.1 ABC-type oligopeptide transporter ABCB9 isoform X4
XM_063271611.1 → XP_063127681.1 ABC-type oligopeptide transporter ABCB9 isoform X3
XM_039089718.2 → XP_038945646.1 ABC-type oligopeptide transporter ABCB9 isoform X2

Conserved Domains (1) summary

TIGR00958
Location:35 → 572

3a01208; Conjugate Transporter-2 (CT2) Family protein