MMP28 matrix metallopeptidase 28 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MMP28provided by HGNC
Official Full Name: matrix metallopeptidase 28provided by HGNC
Primary source: HGNC:HGNC:14366
See related: Ensembl:ENSG00000271447 MIM:608417; AllianceGenome:HGNC:14366
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MM28; MMP25; MMP-25; MMP-28; EPILYSIN
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression: Broad expression in fat (RPKM 8.8), skin (RPKM 8.6) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (35756249..35795641, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (36704182..36743551, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (34083268..34122645, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression and Clinical Significance of MMP-28 in Bladder Cancer.
Title: Expression and Clinical Significance of MMP-28 in Bladder Cancer.
Real-time PCR and dual-luciferase assay indicated that KLF9 directly inhibited MMP28 transcription. Decreased invasion and metastasis capability of GC cells caused by ectopic KLF9 expression could be rescued via reinforcing MMP28 expression in vivo. Collectively, our study indicates that KLF9 significantly suppresses GC cell invasion and metastasis through inhibiting MMP28 transcription.
Title: KLF9 suppresses gastric cancer cell invasion and metastasis through transcriptional inhibition of MMP28.
Increased bronchoalveolar lavage fluid MMP28 concentrations were associated with increased % percentage alveolar neutrophils and total protein concentrations
Title: Alveolar MMP28 is associated with clinical outcomes and measures of lung injury in acute respiratory distress syndrome.
MMP28 is upregulated in epithelial cells from Idiopathic pulmonary fibrosis lungs.
Title: Upregulation and Nuclear Location of MMP28 in Alveolar Epithelium of Idiopathic Pulmonary Fibrosis.
Circulating MMP-28 was elevated in atrial fibrillation
Title: Potential roles of circulating matrix metalloproteinase-28 (MMP-28) in patients with atrial fibrillation.
Results suggest a crucial role of MMP9 at the early stage of carcinogenesis in the large intestine. The increase in MMP9 and TIMP1 mRNA concentration and the decrease in MMP28 in the large intestinal tissue may be a confirmation of cancer.
Title: Profile of Expression of Genes Encoding Matrix Metallopeptidase 9 (MMP9), Matrix Metallopeptidase 28 (MMP28) and TIMP Metallopeptidase Inhibitor 1 (TIMP1) in Colorectal Cancer: Assessment of the Role in Diagnosis and Prognostication.
These results proved for the first time that epilysin expression was significantly elevated in glioblastoma
Title: Epilysin is overexpressed in glioblastoma and related to clinical outcome of patients.
A decreased level of IL-33 and an elevated concentration of MMP-28 were found in coronary heart disease patients and correlated with disease severity.
Title: Characterization of interleukin-33 and matrix metalloproteinase-28 in serum and their association with disease severity in patients with coronary heart disease.
MMP28 mRNA expression is highest in healthy tissues when compared to diseased periodontal tissues.
Title: mRNA expression of MMP-28 (Epilysin) in gingival tissues of chronic and aggressive periodontitis patients: a reverse transcriptase PCR study.
Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC).
Title: Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MMP28_924.2 (e-PCR)
- UniSTS:280849

D17S1833 (e-PCR), detects polymorphism
- UniSTS:1400

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of macrophage chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: matrix metalloproteinase-28

Names: matrix metalloprotease MMP25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032278.3 → NP_001027449.1 matrix metalloproteinase-28 isoform 3 precursor

See identical proteins and their annotated locations for NP_001027449.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks multiple 3' exons but includes an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is significantly shorter than isoform 1.

Source sequence(s)

AK122604, BC011774, HY027589

Consensus CDS

CCDS45651.1

UniProtKB/Swiss-Prot

Q9H239

UniProtKB/TrEMBL

B3KV06

Related

ENSP00000483539.1, ENST00000612672.1

Conserved Domains (1) summary

pfam01471
Location:31 → 86

PG_binding_1; Putative peptidoglycan binding domain
NM_024302.5 → NP_077278.1 matrix metalloproteinase-28 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_077278.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1)

Source sequence(s)

AA813101, AF330002, AK122604

Consensus CDS

CCDS74036.1

UniProtKB/Swiss-Prot

Q96F04, Q96TE2, Q9H239

UniProtKB/TrEMBL

B3KV06

Related

ENSP00000473853.1, ENST00000605424.6

Conserved Domains (4) summary

cd00094
Location:321 → 510

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:129 → 284

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:129 → 284

Peptidase_M10; Matrixin

pfam01471
Location:31 → 86

PG_binding_1; Putative peptidoglycan binding domain
NM_032950.4 → NP_116568.1 matrix metalloproteinase-28 isoform 2 preproprotein

See identical proteins and their annotated locations for NP_116568.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional exon in the 3' region, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AA813101, AF330002, AK122604, BC002631

Consensus CDS

CCDS76996.1

UniProtKB/TrEMBL

C0H5X0

Related

ENSP00000483299.1, ENST00000615136.4

Conserved Domains (3) summary

cd04278
Location:129 → 284

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam01471
Location:31 → 86

PG_binding_1; Putative peptidoglycan binding domain

cl02471
Location:321 → 389

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

RNA

NR_111988.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice site in an internal exon and contains alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC015849, AK122604, BM702847

Related

ENST00000619655.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

35756249..35795641 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017025064.2 → XP_016880553.1 matrix metalloproteinase-28 isoform X6
XM_011525231.2 → XP_011523533.1 matrix metalloproteinase-28 isoform X5

Conserved Domains (4) summary

cd04278
Location:129 → 284

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:129 → 284

Peptidase_M10; Matrixin

pfam01471
Location:31 → 86

PG_binding_1; Putative peptidoglycan binding domain

cl02471
Location:321 → 389

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
XM_011525225.2 → XP_011523527.1 matrix metalloproteinase-28 isoform X2

See identical proteins and their annotated locations for XP_011523527.1

UniProtKB/TrEMBL

B3KV06

Conserved Domains (4) summary

cd00094
Location:246 → 435

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:122 → 209

Peptidase_M10; Matrixin

pfam01471
Location:31 → 86

PG_binding_1; Putative peptidoglycan binding domain

cl00064
Location:126 → 209

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_011525232.3 → XP_011523534.2 matrix metalloproteinase-28 isoform X1

UniProtKB/TrEMBL

B3KV06
XM_011525230.2 → XP_011523532.1 matrix metalloproteinase-28 isoform X4

Conserved Domains (4) summary

cd04278
Location:129 → 284

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:129 → 284

Peptidase_M10; Matrixin

pfam01471
Location:31 → 86

PG_binding_1; Putative peptidoglycan binding domain

cl02471
Location:321 → 409

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
XM_011525226.3 → XP_011523528.1 matrix metalloproteinase-28 isoform X3

See identical proteins and their annotated locations for XP_011523528.1

UniProtKB/TrEMBL

B3KV06

Conserved Domains (2) summary

cd00094
Location:236 → 425

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:44 → 199

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
XM_011525229.3 → XP_011523531.1 matrix metalloproteinase-28 isoform X3

See identical proteins and their annotated locations for XP_011523531.1

UniProtKB/TrEMBL

B3KV06

Conserved Domains (2) summary

cd00094
Location:236 → 425

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:44 → 199

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
XM_011525227.2 → XP_011523529.1 matrix metalloproteinase-28 isoform X3

See identical proteins and their annotated locations for XP_011523529.1

UniProtKB/TrEMBL

B3KV06

Conserved Domains (2) summary

cd00094
Location:236 → 425

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:44 → 199

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
XM_047436731.1 → XP_047292687.1 matrix metalloproteinase-28 isoform X3
XM_024450943.2 → XP_024306711.1 matrix metalloproteinase-28 isoform X3

UniProtKB/TrEMBL

B3KV06

Conserved Domains (2) summary

cd00094
Location:236 → 425

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:44 → 199

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
XM_017025063.2 → XP_016880552.1 matrix metalloproteinase-28 isoform X6