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    ITGA2 integrin subunit alpha 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 489208, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ITGA2provided by VGNC
    Official Full Name
    integrin subunit alpha 2provided by VGNC
    Primary source
    VGNC:VGNC:42123
    See related
    Ensembl:ENSCAFG00845000432
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (62664801..62766959, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (61941741..62043869, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (63091317..63193515, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (62440055..62542152, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (62564620..62666770, complement)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene myocilin opposite strand protein-like Neighboring gene molybdenum cofactor synthesis 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene 60S ribosomal protein L36a-like Neighboring gene integrin subunit alpha 1 Neighboring gene pelota mRNA surveillance and ribosome rescue factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data demonstrate that G alpha 12 inhibits interaction of MDCK cells with collagen-I, the major ligand for alpha2 beta1 integrin, and regulates epithelial cell spreading and migration necessary for normal tubulogenesis.
      Title: G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis.
    2. galectin-3 influences integrin alpha(2)beta(1)-mediated adhesion complex formation by altering receptor clustering
      Title: Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin alpha-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      62664801..62766959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038663725.1 → XP_038519653.1  integrin alpha-2

      UniProtKB/TrEMBL
      A0A8C0LX24, A0A8C0S0G4, A0A8I3MC22
      Related
      ENSCAFP00845000505.1, ENSCAFT00845000697.1
      Conserved Domains (3) summary
      smart00191
      Location:549 → 602
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:647 → 1058
      Integrin_alpha2; Integrin alpha
      cl00057
      Location:171 → 351
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      62440055..62542152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038474023.1 → XP_038329951.1  integrin alpha-2

      Conserved Domains (3) summary
      smart00191
      Location:549 → 602
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:647 → 1058
      Integrin_alpha2; Integrin alpha
      cl00057
      Location:171 → 351
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      62564620..62666770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038599416.1 → XP_038455344.1  integrin alpha-2

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      63091317..63193515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038535122.1 → XP_038391050.1  integrin alpha-2

      UniProtKB/TrEMBL
      A0A8C0LX24, A0A8C0S0G4, A0A8I3MC22
      Conserved Domains (3) summary
      smart00191
      Location:549 → 602
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:647 → 1058
      Integrin_alpha2; Integrin alpha
      cl00057
      Location:171 → 351
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      61941741..62043869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005619334.4 → XP_005619391.1  integrin alpha-2

      UniProtKB/TrEMBL
      A0A8C0LX24, A0A8C0S0G4, A0A8I3MC22
      Conserved Domains (3) summary
      smart00191
      Location:549 → 602
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:647 → 1058
      Integrin_alpha2; Integrin alpha
      cl00057
      Location:171 → 351
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein
    Heading Accession and Version

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