Tril TLR4 interactor with leucine-rich repeats [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trilprovided by RGD
Official Full Name: TLR4 interactor with leucine-rich repeatsprovided by RGD
Primary source: RGD:1310827
See related: Ensembl:ENSRNOG00000026941 AllianceGenome:RGD:1310827
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310827
Summary: Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in regulation of cytokine production involved in immune response and toll-like receptor 4 signaling pathway. Predicted to be part of lipopolysaccharide receptor complex. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human TRIL (TLR4 interactor with leucine rich repeats). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (84252781..84257626, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (82922327..82927172, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (83967695..83972540, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reports data for human and mouse TRIL
Title: TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134893 (e-PCR)
- UniSTS:218171

RH143563 (e-PCR)
- UniSTS:232809

RH134022 (e-PCR)
- UniSTS:217304

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipopolysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of lipopolysaccharide receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of lipopolysaccharide receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TLR4 interactor with leucine rich repeats

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034010.2 → NP_001029182.1 TLR4 interactor with leucine rich repeats precursor

See identical proteins and their annotated locations for NP_001029182.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q496Z2

UniProtKB/TrEMBL

A6K0U0

Related

ENSRNOP00000037327.1, ENSRNOT00000036951.3

Conserved Domains (6) summary

smart00060
Location:589 → 661

FN3; Fibronectin type 3 domain

cd00116
Location:22 → 313

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:327 → 340

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:85 → 108

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:229 → 289

LRR_8; Leucine rich repeat

cl15307
Location:359 → 406

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain