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    ARMC8 armadillo repeat containing 8 [ Homo sapiens (human) ]

    Gene ID: 25852, updated on 5-May-2024

    Summary

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    Official Symbol
    ARMC8provided by HGNC
    Official Full Name
    armadillo repeat containing 8provided by HGNC
    Primary source
    HGNC:HGNC:24999
    See related
    Ensembl:ENSG00000114098 MIM:618521; AllianceGenome:HGNC:24999
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GID5; VID28; S863-2; HSPC056
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.0), thyroid (RPKM 5.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q22.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (138187248..138298389)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (140927839..141038955)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (137906090..138017231)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene alpha-1,4-N-acetylglucosaminyltransferase Neighboring gene OCT4 hESC enhancer GRCh37_chr3:137879291-137879792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20601 Neighboring gene debranching RNA lariats 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20602 Neighboring gene NME/NM23 family member 9 Neighboring gene uncharacterized LOC124909438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:138066933-138067888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:138078932-138079766 Neighboring gene MPRA-validated peak4844 silencer Neighboring gene muscle RAS oncogene homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Armadillo Repeat-Containing Protein 8 (ARMC8) Silencing Inhibits Proliferation and Invasion in Osteosarcoma Cells. Jiang F, et al. Oncol Res, 2016. PMID 27712595, Free PMC Article
    2. Armc8 regulates the invasive ability of hepatocellular carcinoma through E-cadherin/catenin complex. Zhao Y, et al. Tumour Biol, 2016 Aug. PMID 26944057
    3. A novel biomarker ARMc8 promotes the malignant progression of ovarian cancer. Jiang G, et al. Hum Pathol, 2015 Oct. PMID 26232863
    4. ARMc8 indicates aggressive colon cancers and promotes invasiveness and migration of colon cancer cells. Jiang G, et al. Tumour Biol, 2015 Nov. PMID 26081621
    5. Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma. Fan C, et al. Tumour Biol, 2014 Nov. PMID 25119601

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-455-3p inhibits gastric cancer progression by repressing Wnt/beta-catenin signaling through binding to ARMC8.
      Title: MiR-455-3p inhibits gastric cancer progression by repressing Wnt/β-catenin signaling through binding to ARMC8.
    2. Downregulation of ARMC8 promotes tumorigenesis through activating Wnt/beta-catenin pathway and EMT in cutaneous squamous cell carcinomas.
      Title: Downregulation of ARMC8 promotes tumorigenesis through activating Wnt/β-catenin pathway and EMT in cutaneous squamous cell carcinomas.
    3. Armc8 is an evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions.
      Title: Armc8 is an evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions.
    4. Knockdown of ARMC8 significantly inhibited osteosarcoma cell proliferation in vitro and markedly inhibited xenograft tumor growth in vivo. ARMC8 silencing also suppressed the epithelial-mesenchymal transition (EMT) phenotype, as well as inhibited the migration and invasion of osteosarcoma cells.
      Title: Armadillo Repeat-Containing Protein 8 (ARMC8) Silencing Inhibits Proliferation and Invasion in Osteosarcoma Cells.
    5. results indicate that Armc8 may be a potential cancer marker in hepatocellular carcinoma
      Title: Armc8 regulates the invasive ability of hepatocellular carcinoma through E-cadherin/catenin complex.
    6. invasiveness and migration capacity of HT29 cells transfected with ARMc8 were significantly greater than those of control cells (p < 0.001), while ARMc8 siRNA treatment significantly reduced cell invasion and migration in LoVo cells
      Title: ARMc8 indicates aggressive colon cancers and promotes invasiveness and migration of colon cancer cells.
    7. ARMc8 may enhance the invasion and metastasis of ovarian cancer cells
      Title: A novel biomarker ARMc8 promotes the malignant progression of ovarian cancer.
    8. Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma.
      Title: Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma.
    9. Data suggest that armadillo repeat containing protein 8 (ARMC8) might serve as a therapeutic target in non-small cell lung cancer (NSCLC).
      Title: ARMC8α promotes proliferation and invasion of non-small cell lung cancer cells by activating the canonical Wnt signaling pathway.
    10. RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells
      Title: RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC4880, MGC10058

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in specific granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    armadillo repeat-containing protein 8
    Names
    GID complex subunit 5, VID28 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267041.2 → NP_001253970.1  armadillo repeat-containing protein 8 isoform 3

      See identical proteins and their annotated locations for NP_001253970.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AK296837, AK299769, AL096748, BQ014283, HY004298
      Consensus CDS
      CCDS58854.1
      UniProtKB/Swiss-Prot
      Q8IUR7
      UniProtKB/TrEMBL
      B7Z637
      Related
      ENSP00000441592.1, ENST00000538260.5
      Conserved Domains (4) summary
      COG5064
      Location:22 → 181
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:343 → 576
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:522 → 552
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:57 → 90
      ARM; armadillo repeat [structural motif]

    2. NM_001267042.3 → NP_001253971.1  armadillo repeat-containing protein 8 isoform 4

      See identical proteins and their annotated locations for NP_001253971.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform (4) is longer and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AK296757, AL096748, BQ014283, CX167429
      Consensus CDS
      CCDS58853.1
      UniProtKB/Swiss-Prot
      Q8IUR7
      Related
      ENSP00000420706.1, ENST00000461822.5
      Conserved Domains (4) summary
      COG5064
      Location:28 → 414
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:307 → 540
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:486 → 516
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:57 → 90
      ARM; armadillo repeat [structural motif]

    3. NM_001282342.2 → NP_001269271.1  armadillo repeat-containing protein 8 isoform 5

      See identical proteins and their annotated locations for NP_001269271.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' and 3' UTRs and has multiple differences in the coding region, including the use of a downstream start codon, compared to variant 1. The encoded isoform (5) is longer and has a shorter N-terminus and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK299769, AL096748, BQ014283
      Consensus CDS
      CCDS75020.1
      UniProtKB/TrEMBL
      B7Z5P0, B7Z637
      Related
      ENSP00000417049.1, ENST00000485396.5
      Conserved Domains (4) summary
      COG5064
      Location:3 → 139
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:301 → 534
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:480 → 510
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:15 → 48
      ARM; armadillo repeat [structural motif]

    4. NM_001363941.2 → NP_001350870.1  armadillo repeat-containing protein 8 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC022337, AC068777
      Consensus CDS
      CCDS87139.1
      UniProtKB/Swiss-Prot
      A8K0L2, B7Z441, B7Z453, D3DNE6, F5GWK4, Q6PIL2, Q8IUR7, Q96D19, Q96HZ5, Q9NV02, Q9NV94, Q9Y4R9
      Related
      ENSP00000419413.1, ENST00000469044.6
      Conserved Domains (4) summary
      COG5064
      Location:49 → 212
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:374 → 607
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:553 → 583
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:57 → 90
      ARM; armadillo repeat [structural motif]

    5. NM_001363942.1 → NP_001350871.1  armadillo repeat-containing protein 8 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC022337, AC068777
      Consensus CDS
      CCDS87140.1
      UniProtKB/TrEMBL
      B7Z5P0
      Conserved Domains (4) summary
      COG5064
      Location:7 → 170
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:332 → 565
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:511 → 541
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:15 → 48
      ARM; armadillo repeat [structural motif]

    6. NM_014154.4 → NP_054873.2  armadillo repeat-containing protein 8 isoform 1

      See identical proteins and their annotated locations for NP_054873.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1). Variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AK289577, BC013424, DC342329, HY004298
      Consensus CDS
      CCDS3098.1
      UniProtKB/TrEMBL
      G5E9V6
      Related
      ENSP00000420440.1, ENST00000471453.5
      Conserved Domains (2) summary
      COG5064
      Location:35 → 198
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:43 → 76
      ARM; armadillo repeat [structural motif]

    7. NM_015396.6 → NP_056211.2  armadillo repeat-containing protein 8 isoform 2

      See identical proteins and their annotated locations for NP_056211.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes multiple additional exons in the coding region and differs in the 3' UTR, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL096748, BC041699, BQ014283, HY004298
      Consensus CDS
      CCDS54646.1
      UniProtKB/TrEMBL
      B7Z5P0
      Related
      ENSP00000420333.1, ENST00000481646.5
      Conserved Domains (4) summary
      COG5064
      Location:35 → 198
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:360 → 593
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:539 → 569
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:43 → 76
      ARM; armadillo repeat [structural motif]

    8. NM_213654.3 → NP_998819.1  armadillo repeat-containing protein 8 isoform 1

      See identical proteins and their annotated locations for NP_998819.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      BC013424, HY004298
      Consensus CDS
      CCDS3098.1
      UniProtKB/TrEMBL
      G5E9V6
      Related
      ENSP00000351221.2, ENST00000358441.6
      Conserved Domains (2) summary
      COG5064
      Location:35 → 198
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:43 → 76
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      138187248..138298389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713565.3 → XP_006713628.1  armadillo repeat-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006713628.1

      UniProtKB/TrEMBL
      B7Z5P0
      Conserved Domains (4) summary
      COG5064
      Location:35 → 198
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:360 → 593
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:539 → 569
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:43 → 76
      ARM; armadillo repeat [structural motif]

    2. XM_024453441.2 → XP_024309209.1  armadillo repeat-containing protein 8 isoform X3

      Conserved Domains (4) summary
      COG5369
      Location:329 → 562
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:508 → 538
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:43 → 76
      ARM; armadillo repeat [structural motif]
      cl25709
      Location:8 → 167
      Arm_3; Atypical Arm repeat

    3. XM_011512632.2 → XP_011510934.1  armadillo repeat-containing protein 8 isoform X2

      See identical proteins and their annotated locations for XP_011510934.1

      UniProtKB/TrEMBL
      B7Z5P0
      Related
      ENSP00000417304.1, ENST00000491704.5
      Conserved Domains (4) summary
      COG5064
      Location:7 → 170
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:332 → 565
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:511 → 541
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:15 → 48
      ARM; armadillo repeat [structural motif]

    4. XM_006713566.5 → XP_006713629.1  armadillo repeat-containing protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006713629.1

      UniProtKB/TrEMBL
      B7Z5P0
      Conserved Domains (4) summary
      COG5064
      Location:7 → 170
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:332 → 565
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:511 → 541
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:15 → 48
      ARM; armadillo repeat [structural motif]

    5. XM_047447900.1 → XP_047303856.1  armadillo repeat-containing protein 8 isoform X4

    6. XM_017006100.3 → XP_016861589.1  armadillo repeat-containing protein 8 isoform X5

    7. XM_047447902.1 → XP_047303858.1  armadillo repeat-containing protein 8 isoform X7

      Related
      ENSP00000418405.1, ENST00000470821.5

    8. XM_047447901.1 → XP_047303857.1  armadillo repeat-containing protein 8 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      140927839..141038955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346018.1 → XP_054201993.1  armadillo repeat-containing protein 8 isoform X1

    2. XM_054346021.1 → XP_054201996.1  armadillo repeat-containing protein 8 isoform X3

    3. XM_054346020.1 → XP_054201995.1  armadillo repeat-containing protein 8 isoform X2

    4. XM_054346019.1 → XP_054201994.1  armadillo repeat-containing protein 8 isoform X2

    5. XM_054346022.1 → XP_054201997.1  armadillo repeat-containing protein 8 isoform X4

    6. XM_054346023.1 → XP_054201998.1  armadillo repeat-containing protein 8 isoform X5

    7. XM_054346025.1 → XP_054202000.1  armadillo repeat-containing protein 8 isoform X7

    8. XM_054346024.1 → XP_054201999.1  armadillo repeat-containing protein 8 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IUR7.2 GenPept UniProtKB/Swiss-Prot:Q8IUR7

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