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    MCAM melanoma cell adhesion molecule [ Gallus gallus (chicken) ]

    Gene ID: 448832, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MCAMprovided by CGNC
    Official Full Name
    melanoma cell adhesion moleculeprovided by CGNC
    Primary source
    CGNC:54317
    See related
    Ensembl:ENSGALG00010024116
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    MUC18; mucin-18
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 24 NC_052555.1 (4266882..4274784)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 24 NC_052596.1 (4226347..4234254)

    Chromosome 24 - NC_052555.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417377 Neighboring gene ring finger protein 26 Neighboring gene Cbl proto-oncogene Neighboring gene coiled-coil domain containing 153 Neighboring gene PDZ domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neurite extension of DRG neurons by gicerin expression is enhanced by nerve growth factor. Hiroi S, et al. Int J Mol Med, 2005 Dec. PMID 16273279
    2. HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors. Vainio O, et al. J Cell Biol, 1996 Dec. PMID 8978830, Free PMC Article
    3. Molecular cloning and functional expression of gicerin, a novel cell adhesion molecule that binds to neurite outgrowth factor. Taira E, et al. Neuron, 1994 Apr. PMID 8161457
    4. Expression and functional analysis of a novel isoform of gicerin, an immunoglobulin superfamily cell adhesion molecule. Taira E, et al. J Biol Chem, 1995 Dec 1. PMID 7499388
    5. Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor. Guezguez B, et al. J Immunol, 2007 Nov 15. PMID 17982057

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MCAM might be involved in the recruitment of activated T cells to inflammation sites.
      Title: Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor.
    2. These results indicate that NGF might therefore enhance the expression of gicerin in DRG, thereby promoting the gicerin-dependent neurite extension during sciatic nerve regeneration.
      Title: Neurite extension of DRG neurons by gicerin expression is enhanced by nerve growth factor.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell surface glycoprotein MUC18
    Names
    HEMCAM
    gicerin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396032.1 → NP_001382961.1  cell surface glycoprotein MUC18 precursor 1 precursor

      Status: VALIDATED

      Source sequence(s)
      BM489731, BU127054, BU260394, CD218325, D38559, D49849, DN929995, Y08855, Y08856
      UniProtKB/TrEMBL
      A0A1D5PL70
      Related
      ENSGALP00010035806.1, ENSGALT00010058841.1
      Conserved Domains (3) summary
      smart00409
      Location:277 → 356
      IG; Immunoglobulin
      cd00096
      Location:170 → 175
      Ig; Ig strand B [structural motif]
      cl11960
      Location:164 → 257
      Ig; Immunoglobulin domain

    2. NM_001396033.1 → NP_001382962.1  cell surface glycoprotein MUC18 precursor 2 precursor

      Status: VALIDATED

      Source sequence(s)
      BM489731, BU127054, BU260394, CD218325, D38559, D49849, DN929995, Y08856
      UniProtKB/TrEMBL
      A0A8V0ZZV8
      Related
      ENSGALP00010035818.1, ENSGALT00010058853.1
      Conserved Domains (3) summary
      smart00409
      Location:277 → 356
      IG; Immunoglobulin
      cd00096
      Location:170 → 175
      Ig; Ig strand B [structural motif]
      cl11960
      Location:164 → 257
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4266882..4274784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052596.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      4226347..4234254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004768.1: Suppressed sequence

      Description
      NM_001004768.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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