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    ZFX zinc finger protein X-linked [ Homo sapiens (human) ]

    Gene ID: 7543, updated on 4-Apr-2024

    Summary

    Official Symbol
    ZFXprovided by HGNC
    Official Full Name
    zinc finger protein X-linkedprovided by HGNC
    Primary source
    HGNC:HGNC:12869
    See related
    Ensembl:ENSG00000005889 MIM:314980; AllianceGenome:HGNC:12869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRXS37; ZNF926
    Summary
    This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in endometrium (RPKM 5.2), thyroid (RPKM 4.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    Xp22.11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (24148982..24216255)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (23733193..23800453)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (24167099..24234372)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905261 Neighboring gene uncharacterized LOC124905260 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:24111108-24111608 Neighboring gene small nucleolar RNA SNORA68 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29499 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24167489-24168302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29500 Neighboring gene ZFX antisense RNA 1 Neighboring gene CRISPRi-validated cis-regulatory element chrX.477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:24328768-24329520 Neighboring gene SUPT20H like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:24382719-24383459 Neighboring gene SUPT20H like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in parental behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    zinc finger X-chromosomal protein
    Names
    X-linked zinc finger protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021253.2 RefSeqGene

      Range
      4993..71519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178084.2NP_001171555.1  zinc finger X-chromosomal protein isoform 1

      See identical proteins and their annotated locations for NP_001171555.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons in the 5' UTR, as compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AB209892, AC002404, DA995443, X59739
      Consensus CDS
      CCDS14211.1
      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001178085.1NP_001171556.1  zinc finger X-chromosomal protein isoform 1

      See identical proteins and their annotated locations for NP_001171556.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 5' UTR, as compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AB209892, AC002404, M30608, X59740
      Consensus CDS
      CCDS14211.1
      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
      UniProtKB/TrEMBL
      B7ZKJ5
      Related
      ENSP00000368475.1, ENST00000379177.5
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001178086.2NP_001171557.1  zinc finger X-chromosomal protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several exons in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AB209892, AC002404, X59738
      Consensus CDS
      CCDS55390.1
      UniProtKB/TrEMBL
      Q8WXB7
      Related
      ENSP00000438233.1, ENST00000539115.5
      Conserved Domains (4) summary
      COG5048
      Location:314438
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam04704
      Location:1181
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      cl19880
      Location:169216
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    4. NM_001178095.2NP_001171566.1  zinc finger X-chromosomal protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two exons in the 5' UTR and has an additional segment in the 3' CDS, as compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AB209892, AC002404
      UniProtKB/TrEMBL
      Q59EB9
      Conserved Domains (1) summary
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    5. NM_001330327.2NP_001317256.1  zinc finger X-chromosomal protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and includes an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
      Source sequence(s)
      AA873535, AB209892, AC002404, BC136309, BP311445, BP374479, DA847701
      Consensus CDS
      CCDS83461.1
      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    6. NM_003410.4NP_003401.2  zinc finger X-chromosomal protein isoform 1

      See identical proteins and their annotated locations for NP_003401.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variants 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC002404, AF454950, DA848249, M30608
      Consensus CDS
      CCDS14211.1
      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
      UniProtKB/TrEMBL
      B7ZKJ5
      Related
      ENSP00000304985.5, ENST00000304543.10
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      24148982..24216255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545581.3XP_011543883.1  zinc finger X-chromosomal protein isoform X3

      See identical proteins and their annotated locations for XP_011543883.1

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    2. XM_047442439.1XP_047298395.1  zinc finger X-chromosomal protein isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    3. XM_047442450.1XP_047298406.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    4. XM_047442445.1XP_047298401.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    5. XM_047442440.1XP_047298396.1  zinc finger X-chromosomal protein isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    6. XM_047442451.1XP_047298407.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    7. XM_017029792.2XP_016885281.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    8. XM_005274592.4XP_005274649.1  zinc finger X-chromosomal protein isoform X3

      See identical proteins and their annotated locations for XP_005274649.1

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    9. XM_017029799.2XP_016885288.1  zinc finger X-chromosomal protein isoform X6

      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (6) summary
      COG5048
      Location:496633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:672694
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70357
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:515537
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:380396
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    10. XM_047442436.1XP_047298392.1  zinc finger X-chromosomal protein isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    11. XM_017029794.2XP_016885283.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    12. XM_047442455.1XP_047298411.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    13. XM_047442453.1XP_047298409.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    14. XM_047442441.1XP_047298397.1  zinc finger X-chromosomal protein isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    15. XM_047442448.1XP_047298404.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    16. XM_047442438.1XP_047298394.1  zinc finger X-chromosomal protein isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    17. XM_006724513.4XP_006724576.1  zinc finger X-chromosomal protein isoform X1

      See identical proteins and their annotated locations for XP_006724576.1

      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    18. XM_047442460.1XP_047298416.1  zinc finger X-chromosomal protein isoform X6

    19. XM_047442442.1XP_047298398.1  zinc finger X-chromosomal protein isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    20. XM_047442454.1XP_047298410.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    21. XM_017029790.2XP_016885279.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    22. XM_005274591.5XP_005274648.1  zinc finger X-chromosomal protein isoform X3

      See identical proteins and their annotated locations for XP_005274648.1

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    23. XM_017029791.3XP_016885280.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/TrEMBL
      B7ZKJ5
      Related
      ENSP00000368486.4, ENST00000379188.7
      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    24. XM_047442458.1XP_047298414.1  zinc finger X-chromosomal protein isoform X4

    25. XM_047442461.1XP_047298417.1  zinc finger X-chromosomal protein isoform X6

    26. XM_017029798.3XP_016885287.1  zinc finger X-chromosomal protein isoform X5

      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (5) summary
      COG5048
      Location:518655
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:465485
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:694716
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:45385
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:537559
      zf-H2C2_2; Zinc-finger double domain
    27. XM_047442437.1XP_047298393.1  zinc finger X-chromosomal protein isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    28. XM_047442452.1XP_047298408.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    29. XM_011545579.2XP_011543881.1  zinc finger X-chromosomal protein isoform X3

      See identical proteins and their annotated locations for XP_011543881.1

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    30. XM_047442443.1XP_047298399.1  zinc finger X-chromosomal protein isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    31. XM_047442435.1XP_047298391.1  zinc finger X-chromosomal protein isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    32. XM_047442446.1XP_047298402.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    33. XM_017029788.2XP_016885277.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    34. XM_047442447.1XP_047298403.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    35. XM_024452440.2XP_024308208.1  zinc finger X-chromosomal protein isoform X4

      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (5) summary
      COG5048
      Location:535672
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:482502
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:711733
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109396
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:725749
      zf-H2C2_2; Zinc-finger double domain
    36. XM_047442449.1XP_047298405.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    37. XM_047442444.1XP_047298400.1  zinc finger X-chromosomal protein isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    38. XM_017029789.2XP_016885278.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    39. XM_047442456.1XP_047298412.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    40. XM_047442457.1XP_047298413.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    41. XM_017029793.2XP_016885282.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (6) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:772796
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:416496
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    42. XM_017029795.2XP_016885284.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
      UniProtKB/TrEMBL
      B7ZKJ5
      Related
      ENSP00000343384.3, ENST00000338565.3
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    43. XM_047442459.1XP_047298415.1  zinc finger X-chromosomal protein isoform X5

    44. XM_011545583.4XP_011543885.3  zinc finger X-chromosomal protein isoform X2

    45. XM_005274594.6XP_005274651.1  zinc finger X-chromosomal protein isoform X5

      See identical proteins and their annotated locations for XP_005274651.1

      UniProtKB/TrEMBL
      B7ZKJ5
      Conserved Domains (5) summary
      COG5048
      Location:518655
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:465485
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:694716
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:45385
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:537559
      zf-H2C2_2; Zinc-finger double domain
    46. XM_017029801.2XP_016885290.1  zinc finger X-chromosomal protein isoform X7

      UniProtKB/TrEMBL
      Q8WXB7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      23733193..23800453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327741.1XP_054183716.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    2. XM_054327721.1XP_054183696.1  zinc finger X-chromosomal protein isoform X1

    3. XM_054327740.1XP_054183715.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    4. XM_054327732.1XP_054183707.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    5. XM_054327722.1XP_054183697.1  zinc finger X-chromosomal protein isoform X1

    6. XM_054327742.1XP_054183717.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    7. XM_054327726.1XP_054183701.1  zinc finger X-chromosomal protein isoform X1

    8. XM_054327746.1XP_054183721.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    9. XM_054327759.1XP_054183734.1  zinc finger X-chromosomal protein isoform X6

    10. XM_054327748.1XP_054183723.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    11. XM_054327744.1XP_054183719.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    12. XM_054327723.1XP_054183698.1  zinc finger X-chromosomal protein isoform X1

    13. XM_054327738.1XP_054183713.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    14. XM_054327720.1XP_054183695.1  zinc finger X-chromosomal protein isoform X1

    15. XM_054327717.1XP_054183692.1  zinc finger X-chromosomal protein isoform X1

    16. XM_054327757.1XP_054183732.1  zinc finger X-chromosomal protein isoform X6

    17. XM_054327724.1XP_054183699.1  zinc finger X-chromosomal protein isoform X1

    18. XM_054327745.1XP_054183720.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    19. XM_054327728.1XP_054183703.1  zinc finger X-chromosomal protein isoform X1

    20. XM_054327737.1XP_054183712.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    21. XM_054327725.1XP_054183700.1  zinc finger X-chromosomal protein isoform X1

    22. XM_054327753.1XP_054183728.1  zinc finger X-chromosomal protein isoform X4

    23. XM_054327758.1XP_054183733.1  zinc finger X-chromosomal protein isoform X6

    24. XM_054327754.1XP_054183729.1  zinc finger X-chromosomal protein isoform X5

    25. XM_054327760.1XP_054183735.1  zinc finger X-chromosomal protein isoform X8

    26. XM_054327718.1XP_054183693.1  zinc finger X-chromosomal protein isoform X1

    27. XM_054327735.1XP_054183710.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    28. XM_054327733.1XP_054183708.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    29. XM_054327719.1XP_054183694.1  zinc finger X-chromosomal protein isoform X1

    30. XM_054327727.1XP_054183702.1  zinc finger X-chromosomal protein isoform X1

    31. XM_054327752.1XP_054183727.1  zinc finger X-chromosomal protein isoform X4

    32. XM_054327747.1XP_054183722.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    33. XM_054327739.1XP_054183714.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    34. XM_054327734.1XP_054183709.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    35. XM_054327729.1XP_054183704.1  zinc finger X-chromosomal protein isoform X1

    36. XM_054327749.1XP_054183724.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    37. XM_054327743.1XP_054183718.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    38. XM_054327736.1XP_054183711.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    39. XM_054327750.1XP_054183725.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    40. XM_054327730.1XP_054183705.1  zinc finger X-chromosomal protein isoform X1

    41. XM_054327751.1XP_054183726.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      B9EG97, O43668, P17010, Q8WYJ8
    42. XM_054327756.1XP_054183731.1  zinc finger X-chromosomal protein isoform X5

    43. XM_054327731.1XP_054183706.1  zinc finger X-chromosomal protein isoform X2

    44. XM_054327755.1XP_054183730.1  zinc finger X-chromosomal protein isoform X5

    45. XM_054327761.1XP_054183736.1  zinc finger X-chromosomal protein isoform X7