SLC2A4 solute carrier family 2 member 4 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: SLC2A4provided by VGNC
Official Full Name: solute carrier family 2 member 4provided by VGNC
Primary source: VGNC:VGNC:53442
See related: Ensembl:ENSCAFG00845020724
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: GLUT4
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	5	NC_051809.1 (32343488..32349420)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	5	NC_006587.4 (32376140..32382065)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	5	NC_049226.1 (32444733..32450658)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	5	NC_049265.1 (32308943..32314868)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	5	NC_049746.1 (32267746..32273663)

Chromosome 5 - NC_051809.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that the state of conditioning had a significant effect on the glucose transporter-4 protein (GLUT4) expression at the surface of mononuclear cells.
Title: Conditioning causes an increase in glucose transporter-4 levels in mononuclear cells in sled dogs.
Damage of cardiac function during cardiopulomnary bypass are mostly associated with lower expression of Glut-4 mRNA.
Title: Intervention of rosiglitazone on myocardium Glut-4 mRNA expression during ischemia-reperfusion injury in cardio-pulmonary bypass in dogs.
Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters, GLUT4/12.
Title: Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters.
Suppressed translocation of GLUT-4 was also evident in dogs receiving 30-min ischemia
Title: Cardiac glucose uptake and suppressed expression/translocation of myocardium glucose transport-4 in dogs undergoing ischemia-reperfusion.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables glucose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glucose transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 4

Names: GLUT-4; Insulin-responsive glucose transporter; glucose transporter type 4, insulin-responsive

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159327.2 → NP_001152799.1 solute carrier family 2, facilitated glucose transporter member 4

Status: VALIDATED

Source sequence(s)

JAAUVH010000371

UniProtKB/TrEMBL

A0A8C0K899, A0A8C0Q762, A0A8I3PA13

Related

ENSCAFP00845028720.1, ENSCAFT00845036689.1

Conserved Domains (1) summary

pfam00083
Location:27 → 483

Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051809.1 Reference ROS_Cfam_1.0

Range

32343488..32349420

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038664061.1 → XP_038519989.1 solute carrier family 2, facilitated glucose transporter member 4 isoform X1

UniProtKB/TrEMBL

A0A8C0K899

Conserved Domains (1) summary

cd17431
Location:51 → 499

MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
XM_038664062.1 → XP_038519990.1 solute carrier family 2, facilitated glucose transporter member 4 isoform X2

UniProtKB/TrEMBL

A0A8C0KB74, A0A8C0QYG1

Conserved Domains (1) summary

cl28910
Location:1 → 317

MFS; Major Facilitator Superfamily