NEW
Try the new Transcript table
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_023264.1 RefSeqGene
- Range
-
5001..37959
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_570
mRNA and Protein(s)
-
NM_000930.5 → NP_000921.1 tissue-type plasminogen activator isoform 1 preproprotein
See identical proteins and their annotated locations for NP_000921.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
- Source sequence(s)
-
BC013968, DA031108, DC424502
- Consensus CDS
-
CCDS6126.1
- UniProtKB/Swiss-Prot
- A8K022, B2R8E8, P00750, Q15103, Q503B0, Q6PJA5, Q7Z7N2, Q86YK8, Q9BU99, Q9BZW1
- UniProtKB/TrEMBL
-
B8ZX62
- Related
- ENSP00000220809.4, ENST00000220809.9
- Conserved Domains (4) summary
-
- smart00058
Location:41 → 83
- FN1; Fibronectin type 1 domain
- cd00108
Location:125 → 209
- KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
- cd00190
Location:313 → 559
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam00051
Location:215 → 296
- Kringle; Kringle domain
-
NM_001319189.2 → NP_001306118.1 tissue-type plasminogen activator isoform 4 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1. This isoform (4) may undergo proteolytic processing similar to isoform 1.
- Source sequence(s)
-
AK297738, BC002795, DA031108
- Consensus CDS
-
CCDS83291.1
- UniProtKB/TrEMBL
- B4DN26, B4DV92, E7ESF4
- Related
- ENSP00000429401.1, ENST00000524009.5
- Conserved Domains (3) summary
-
- smart00058
Location:41 → 83
- FN1; Fibronectin type 1 domain
- cd00190
Location:224 → 470
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam00051
Location:126 → 207
- Kringle; Kringle domain
-
NM_033011.4 → NP_127509.1 tissue-type plasminogen activator isoform 3 precursor
See identical proteins and their annotated locations for NP_127509.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 1.
- Source sequence(s)
-
BC002795, DA031108, DC424502
- Consensus CDS
-
CCDS6127.1
- UniProtKB/TrEMBL
-
B8ZX62
- Related
- ENSP00000270188.6, ENST00000352041.7
- Conserved Domains (4) summary
-
- smart00020
Location:264 → 510
- Tryp_SPc; Trypsin-like serine protease
- cd00108
Location:79 → 163
- KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
- cd00190
Location:267 → 513
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam00051
Location:169 → 250
- Kringle; Kringle domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000008.11 Reference GRCh38.p14 Primary Assembly
- Range
-
42174718..42207565 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060932.1 Alternate T2T-CHM13v2.0
- Range
-
42449037..42481874 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_000931.2: Suppressed sequence
- Description
- NM_000931.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.