Pwp2 PWP2, small subunit processome component [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pwp2provided by RGD
Official Full Name: PWP2, small subunit processome componentprovided by RGD
Primary source: RGD:1582817
See related: Ensembl:ENSRNOG00000001210 AllianceGenome:RGD:1582817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Orthologous to human PWP2 (PWP2 small subunit processome component). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 88.9), Spleen (RPKM 82.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (10498998..10512631)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (10499332..10512965)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (11228892..11243204)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Gabrb1 (e-PCR), detects polymorphism
- UniSTS:143152

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: periodic tryptophan protein 2 homolog

Names: PWP2 periodic tryptophan protein homolog; PWP2, UTPB SSU processome subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168653.1 → NP_001162124.1 periodic tryptophan protein 2 homolog

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I6A9Q2, D3ZV54

Related

ENSRNOP00000001605.4, ENSRNOT00000001605.8

Conserved Domains (5) summary

COG2319
Location:33 → 576

WD40; WD40 repeat [General function prediction only]

cd00200
Location:324 → 631

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam04003
Location:773 → 874

Utp12; Dip2/Utp12 Family

sd00039
Location:335 → 373

7WD40; WD40 repeat [structural motif]

cl02567
Location:20 → 403

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...