3664 3748 3753 3770 3773 3895 3904 3931 3987 3995 3999 4115 4116 4119 - GEO DataSets - NCBI

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Select item 58251.

Full record GDS5825

Interleukin-1α deficiency effect on injured spinal cord

Analysis of spinal cord segment from interleukin (IL)-1α -/- and IL-1β -/- C57BL/6 adults 24 hrs after spinal cord injury (SCI). IL-1α and IL-1β belong to a family of cytokines playing a key role in neurodegeneration. Results provide insight into the role of IL-1α in the neuropathology of SCI.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:: GPL6246
Series:: GSE70302
12 Samples

Download data: CEL

DataSet

Accession:: GDS5825

ID:: 5825

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 58812.

Full record GDS5881

Nebulin deficiency effect on the soleus

Analysis of soleus muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE70213
12 Samples

Download data: CEL

DataSet

Accession:: GDS5881

ID:: 5881

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 58803.

Full record GDS5880

Nebulin deficiency effect on the quadriceps

Analysis of quadriceps muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE70213
12 Samples

Download data: CEL

DataSet

Accession:: GDS5880

ID:: 5880

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56654.

Full record GDS5665

Pathogen-associated molecular-pattern curdlan effect on interleukin-2 deficient GM-CSF myeloid dendritic cells

Analysis of GM-CSF myeloid dendritic cells (GM-DCs) isolated from interleukin-2 (IL-2) knockouts and activated with curdlan, a pathogen-associated molecular pattern (PAMP). GM-DCs secrete cytokines such as IL-2, upon PAMP activation. Results provide insight into role of IL-2 signaling in DCs.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE58120
12 Samples

Download data: CEL

DataSet

Accession:: GDS5665

ID:: 5665

PubMed Similar studies GEO Profiles Analyze DataSet

Select item 56185.

Full record GDS5618

Pregnancy effect on transplanted male pancreatic islets

Analysis of male donor islets transplanted into streptozotocin-induced diabetic females then removed at pregnancy day 12.5. During pregnancy, the mother’s insulin demand increases to sustain fetal growth. Results provide insight into the molecular response of male beta cells during pregnancy.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 gender, 4 protocol, 2 tissue sets

Platform:: GPL6246
Series:: GSE59143
20 Samples

Download data: CEL

DataSet

Accession:: GDS5618

ID:: 5618

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 60646.

Full record GDS6064

Arthritic tarsal joints induced by collagen: time course

Analysis of tarsal joints for up to 4 weeks following treatment with collagen to induce arthritis. Collagen induced arthritis is a model for rheumatoid arthritis. Results provide insight into the molecular events underlying the inflammation and bone remodeling that occurs in inflammatory arthritis.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 5 time sets

Platform:: GPL6246
Series:: GSE61140
15 Samples

Download data: CEL

DataSet

Accession:: GDS6064

ID:: 6064

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 58247.

Full record GDS5824

Short-term high fat diet effect on epididymal adipose fractions: time course

Analysis of primary adipocytes from epididymis of C57BL/6J males fed a 60% high fat diet (HFD) for up to 7 days to induce obesity. Results provide insight into the molecular mechanisms underlying insulin resistance in adipose tissues during early obesity.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol, 3 time, 2 tissue sets

Platform:: GPL6246
Series:: GSE65557
18 Samples

Download data: CEL

DataSet

Accession:: GDS5824

ID:: 5824

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 54568.

Full record GDS5456

TGIF1-transduced MLL-AF9-transformed leukemic cells

Analysis of mixed lineage leukemia (MLL)-AF9 transformed cells (MAF9) transduced with TGF-β induced factor 1 (TGIF1). TGIF1 is a member of the TALE (three-amino-acid loop extension) family of homeodomain-containing transcription factors. Results provide insight into the role of TGIF1 in MAF9 cells.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL6246
Series:: GSE55713
6 Samples

Download data: CEL

DataSet

Accession:: GDS5456

ID:: 5456

PubMed Similar studies GEO Profiles Analyze DataSet

Select item 53329.

Full record GDS5332

Death receptor knockout effect on NEMO-deficient model of chronic liver disease

Analysis of livers from hepatocyte-specific NF-ĸB essential modulator (NEMO), NEMO-TRIAL, and NEMO-TNFR null males. NEMO deletion in hepatocytes causes spontaneous hepatocyte apoptosis. TNFR1 and TRAIL encode death receptors. Results provide insight into the role of death receptors in liver injury.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:: GPL6246
Series:: GSE33161
11 Samples

Download data: CEL

DataSet

Accession:: GDS5332

ID:: 5332

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 542110.

Full record GDS5421

Transcription factor E2-2 haplodeficiency effect on systemic lupus erythematosus model: splenocytes

Analysis of splenocytes from WT, B6.Sle1.Sle3 (lupus mice) and B6.Sle1.Sle3 Tcf4+/− (Sle/het) mice haplodeficient for the transcription factor E2-2 (Tcf4). E2-2 is a specific regulator of plasmacytoid dendritic cell (pDC) development. Results provide insight into role of pDC in SLE pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 genotype/variation sets

Platform:: GPL6246
Series:: GSE57324
8 Samples

Download data: CEL

DataSet

Accession:: GDS5421

ID:: 5421

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 541911.

Full record GDS5419

MEK inhibitor PD-0325901 and rapamycin combined treatment effect on malignant peripheral nerve sheath tumor model

Analysis of malignant peripheral nerve sheath tumors (MPNST) from NPcis animals (carrying Nf1 and p53 mutations) treated with rapamycin, MEK inhibitor PD-0325901, or the combination of rapamycin and PD-0325901. Results provide insight into the molecular mechanisms underlying MPNST pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 4 protocol sets

Platform:: GPL6246
Series:: GSE57141
8 Samples

Download data: CEL

DataSet

Accession:: GDS5419

ID:: 5419

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 507812.

Full record GDS5078

Fra-1 deficient lung response to fibrotic agent bleomycin

Analysis of lungs from Fra-1 deficient mutants 5 days following intratracheal administration of bleomycin to induce lung fibrosis. Fra-1 is a b-ZIP transcription factor. Results provide insight into the molecular mechanisms by which Fra-1 protects against bleomycin-induced lung injury.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE43695
12 Samples

Download data: CEL

DataSet

Accession:: GDS5078

ID:: 5078

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 528913.

Full record GDS5289

Lung eosinophil response to allergen challenge

Analysis of lung eosinophils of sensitized animals exposed intranasally to ovalbumin to induce eosinophilia. Eosinophilia, higher than normal eosinophil count, is a feature of allergic asthma. Results provide insight into the molecular response of eosinophils to allergen challenge.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent sets

Platform:: GPL6246
Series:: GSE57757
7 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5289

ID:: 5289

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 532014.

Full record GDS5320

Platelet-derived growth factor C transgenic model of hepatocellular carcinoma: liver stromal cells

Analysis of liver stroma from 8.8-week-old PDGF-C transgenics wherein PDGF-C is ectopically expressed in hepatocytes. The transgenics develop progressive liver fibrosis with a high incidence of HCC. Results provide insight into PDGF-C-driven molecular changes in liver stroma contributing to HCC.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE38199
16 Samples

Download data: CEL

DataSet

Accession:: GDS5320

ID:: 5320

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 566815.

Full record GDS5668

Macrophage-restricted interleukin-10 receptor deficiency effect on colonic resident macrophages

Analysis of FACS-sorted, interleukin-10 receptor (IL-10R)-deficient intestinal macrophages from 6-week-old C57BL/6 animals. IL-10 is a pleiotropic anti-inflammatory cytokine. Results provide insight into the role of IL-10 sensing by intestinal macrophages in gut homeostasis.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE56444
5 Samples

Download data: CEL

DataSet

Accession:: GDS5668

ID:: 5668

PubMed Similar studies GEO Profiles Analyze DataSet

Select item 493316.

Full record GDS4933

Gain-of-function model for conditional activation of IKK2/NF-κB in pancreatic beta-cells

Analysis of islets from 11-week-old Inhibitor of κB kinase 2/pancreatic and duodenal homeobox 1 transgenics. The IKK2/Pdx-1 model allows activation of proinflammatory IKK2/NF-κB signaling, specific to β-cells. Results provide insight into molecular consequences of NF-κB activation in β-cells.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:: GPL6246
Series:: GSE47504
14 Samples

Download data: CEL

DataSet

Accession:: GDS4933

ID:: 4933

PubMed Similar studies GEO Profiles Analyze DataSet

Select item 567317.

Full record GDS5673

Glucagon effect on hepatocytes deficient in lysine acetyltransferase 2B or WD repeat-containing protein 5

Analysis of C57BL6/J primary hepatocytes depleted of either lysine acetyltransferase 2B (KAT2B) or WD repeat-containing protein 5 (WDR5) via shRNA knockdown, then stimulated with glucagon for 90 minutes. Results provide insight into the roles of KAT2B and WDR5 in hepatic gluconeogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 3 genotype/variation sets

Platform:: GPL6246
Series:: GSE47179
10 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5673

ID:: 5673

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 564118.

Full record GDS5641

Retinoblastoma ∆G/∆G mutant allele effect on quiescent embryonic fibroblasts

Analysis of retinoblastoma (RB) ∆G/∆G mutant MEFs deprived of serum to induce quiescence. The mutant allele disrupts RB protein (pRB) interactions with the transactivation domain of E2F transcription factors. Results provide insight into pRB functions in cell cycle control independent of E2F.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:: GPL6246
Series:: GSE54924
9 Samples

Download data: CEL

DataSet

Accession:: GDS5641

ID:: 5641

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 541419.

Full record GDS5414

Core binding factor β deficiency effect on bone marrow derived-granulocyte macrophage progenitor cells

Analysis of purified Lin-c-kit+Sca1-CD16/32+ GMP cells from Cbfβ-conditional knockout mice. Runx/Cbfb heterodimers play important roles in hematopoietic cell development. Results provide insight into molecular mechanisms by which Cbfβ regulates cell fate decisions in bone marrow progenitors.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE55227
4 Samples

Download data: CEL

DataSet

Accession:: GDS5414

ID:: 5414

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 541320.

Full record GDS5413

Core binding factor β deficiency effect on bone marrow derived-LSK hematopoietic stem cells

Analysis of purified Lin-c-kit+Sca1+ LSK cells from Cbfβ- conditional knockout mice. Runx/Cbfb heterodimers play important roles in hematopoietic cell development. Results provide insight into molecular mechanisms by which Cbfβ regulates cell fate decisions in bone marrow progenitors.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE55227
4 Samples

Download data: CEL

DataSet

Accession:: GDS5413

ID:: 5413

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

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