GEO DataSets

(Submitter supplied) Mice were pretreated with anti-radiation drugs before irradiation，including amifostine, bacterial flagellin, recombinant human thrombopoietin , nilestriol tablets. Comparing the gene expression profile of the mice in the drug pretreatment group and the radiation control group, the gene with the opposite expression was screened out. The down-regulated gene phospholipase C gmma 1 (Plcg1) was screened out after the action of anti-radiation drugs.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL10192 GPL15887

44 Samples

Download data: PAIR

(Submitter supplied) We infected adult (6-8 weeks) and old (62-72 weeks) mice with RSV or mock control and determined transcriptional responses in their lungs.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

28 Samples

Download data: FTR

(Submitter supplied) Investigation of whole genome gene expression level changes in GW501516 (a Ppard ligand) or Il-4 treated Ppard-overexpressing RAW 264.7 macrophages as compared to vehicle. Alternative activation of adipose tissue resident macrophages inhibits obesity-induced metabolic inflammation. In the current study we profile genes regulated by two M2 inducers, Il-4 or Ppard agonists and find that alternative activation promotes the cell survival program, while inhibiting that of inflammation-related cell death.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

9 Samples

Download data: PAIR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Methylation profiling by genome tiling array

Platforms:

GPL15761 GPL10192

10 Samples

Download data: GFF, PAIR

(Submitter supplied) Foetal skin is known to heal without scar. This ability is lost in the third trimester of gestation. In mouse, scarless wound healing was reported until the day 15-16 of gestation. A range of factors that could explain the mechanisms of scarless skin wound healing have been identified, to mention reduced immune response, a greater proportion of collagen type III, hyaluronic acid and transforming growth factor beta isoform 3. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

5 Samples

Download data: PAIR

(Submitter supplied) The KMT2A/MLL1 lysine methyltransferase complex is an epigenetic regulator of selected developmental genes, in part through the SET-domain-catalyzed methylation of H3K4. It is essential for normal embryonic development and haematopoiesis and frequently mutated in cancer. The catalytic properties and targeting of KMT2A/MLL1 depend on the proteins with which it complexes and the post-translational protein modifications which some of these proteins put in place, though detailed mechanisms remain unclear. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

10 Samples

Download data: XYS

(Submitter supplied) Investigation of global genome gene expression changes in cardiac-spcifically overexpressed calreticulin mice in 8-10 weeks-old male mice, compared to age and gender matched control mice The characteristics of the transgenic mice analyzed in this study are further discribed in Calreticulin Induces Dilated Cardiomyopathy, PLOS ONE 2013; 8(2): e56387

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

6 Samples

Download data: PAIR, TXT, XYS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Methylation profiling by genome tiling array

Platforms:

GPL10192 GPL15761

12 Samples

Download data: GFF, PAIR

(Submitter supplied) The neonatal murine heart is able to regenerate after severe injury, however this capacity quickly diminishes within the first week of life. Since DNA methylation is one of epigenetic mechanisms that plays a crucial role in cell development and gene expression regulation, we explored the changes of DNA methylation and gene expression patterns which accompany the loss of the transient regenerative potential in the heart. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

8 Samples

Download data: PAIR, TXT

(Submitter supplied) Frequent shift work causes disruption of the circadian rhythm and might on the long-term result in increased health risk. Current biomarkers evaluating the presence of circadian rhythm disturbance (CRD) require 24-hr (around the clock) measurements, which is not practical for use in large-scale (human) studies. The aim of the present study was to identify universal biomarkers for CRD independent of time of day using a transcriptomics approach. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

120 Samples

Download data: FTR

(Submitter supplied) Investigation of whole genome gene expression level changes in the liver tissue from LPS/GalN treated mice, compared to LPS treated mice Treatment of mice with LPS and the liver-specific transcriptional inhibitor D-(+)-galactosamine (GalN) induces fatal hepatitis, which is mediated by TNFα and characterized by massive hepatic apoptosis. Previous studies suggest that GalN increases the sensitivity to LPS/TNFα probably by blocking the transcription of protective factors, but the identity of most of these factors is still unclear. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

6 Samples

Download data: CALLS, PAIR

(Submitter supplied) Small scale study to asses the effects of taking multiple skinbiopts from individual mice in time. Results showed no influence on expression levels in time from older samplings on newer samplings.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

24 Samples

Download data: FTR

(Submitter supplied) Schistosomiasis japonica remains a significant public health problem in China and Southeast Asian countries. The most typical and serious outcome of the chronic oriental schistosomiasis is the progressive granuloma and fibrosis in the host liver, which has been a major medical challenge. However, the molecular mechanisms that underlie the hepatic pathogenesis induced by schistosomal egg deposition have not yet been well-defined. more...

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL10192

4 Samples

Download data: PAIR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL9185 GPL10192

16 Samples

Download data: PAIR, TXT

(Submitter supplied) The global prevalence of type 2 diabetes (T2D) is increasing, and it is contributing to the susceptibility to diabetes and its related epidemic in offspring. Although the impacts of paternal T2D on metabolism of offspring have been well established, the exact molecular and mechanistic basis that mediates these impacts remains largely unclear. Here we show that paternal T2D increases the susceptibility to diabetes in offspring through the gametic epigenetic alterations. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

12 Samples

Download data: PAIR

(Submitter supplied) Mesenchymal stem cells (MSCs) exhibit immunosuppressive properties. However the homing mechanisms underlying MSC trafficking to target tissues remain elusive. Here we report that skin-derived MSCs (S-MSCs) secrete high levels of interleukin-6 (IL-6), inhibit T helper (Th)1- and Th17-cell differentiation, and possess IL-6-dependent immunomodulatory capacity in inflammatory microenvironment. Disruption of the il6 locus or its signaling transducer gp130 blocks voltage-operated calcium (Ca2+) channels (VOCC) critically required for cell contraction involved in the sequential adhesion and de-adhesion events during S-MSC migration. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

2 Samples

Download data: PAIR

(Submitter supplied) Investigation of whole genome gene expression level changes in a Tim-3 knockdown RAW264.7 cell, compared to control siRNA transfected RAW264.7 cell. The Tim-3 knockdown of this cell render it hyper-reactive to TLR stimulation. Tim-3 knockdown analyzed in this study are further described in Li Y, Feng J, Geng S, Geng S, Wei H, Chen G, Li X, Wang L, Wang R, Peng H, Han G, Shen B, Li Y. 2011. The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

6 Samples

Download data: CALLS, PAIR

(Submitter supplied) Investigation of whole genome gene expression level changes in Mus musculus 3B4.15 T hybridoma cells treated with 1microMolar Dexamethasone compared to mock treated cells. Interleukin-7 receptor alpha (IL-7Rα) is essential for T cell survival and differentiation. Glucocorticoids are potent enhancers of IL-7Rα expression with diverse roles in T cell biology. Here we identify the transcriptional repressor, Growth factor independent-1 (Gfi1), as a novel intermediary in glucocorticoid-induced IL-7Rα upregulation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

6 Samples

Download data: PAIR

(Submitter supplied) Examination of genome-wide, gene expression level differences among adult and fetal mammary sub-populations including fetal CD24high cells and adult CD49fhighCD24medium cells which harbor enriched mammary stem cell activity.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10192

12 Samples

Download data: PAIR

(Submitter supplied) Study to optimize our protocol for isolating RNA from skin biopsies from (hairless) SKH mice using different-diameter biopsy punches. Some mice were also treated with UVB radiation to check its effect on RNA yield.

Organism:

Mus musculus

Type:

Other

Platform:

GPL10192

12 Samples

Download data: FTR