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Links from GEO DataSets

Items: 1 to 20 of 136

1.
Full record GDS5610

Heritable pulmonary arterial hypertension: cardiac right ventricular wall

Analysis of biopsies of right ventricle (RV) from patients with pulmonary arterial hypertension (PAH) with bone morphogenetic protein receptor type II (BMPR2) mutation. Results provide insight into molecular mechanisms underlying the metabolic effects of mutant BMPR2 in PAH RVs.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 disease state sets
Platform:
GPL6244
Series:
GSE67492
6 Samples
Download data: CEL
2.
Full record GDS5948

Zipper-interacting protein kinase deficiency effect on coronary artery smooth muscle cells in vitro

Analysis of cultured vascular smooth muscle cells following knockdown of zipper-interacting protein kinase (ZIPK). ZIPK is phosphorylated and activated by Rho-associated kinase 1 (ROCK1). These results, together with those from GDS5659, provide further insight into ROCK1 and ZIPK functions.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6244
Series:
GSE56819
6 Samples
Download data: CEL
3.
Full record GDS5914

YAP transcriptional regulator depletion effect on endothelial cells

Analysis of umbilical vein endothelial HUVEC cells depleted for the transcriptional regulator YAP. YAP binds to the SH3 domain of the transcriptional activator Yes. Results provide insight into the role of YAP in endothelial cell proliferation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent, 2 protocol sets
Platform:
GPL6244
Series:
GSE61989
12 Samples
Download data: CEL
4.
Full record GDS5815

Sunitinib effect on renal cancer xenograft tumors

Analysis of Kyoto University Renal Cancer (KURC) xenograft tumor models, KURC1, KURC2, KURC3, treated with sunitinib, a small molecule inhibitor of receptor tyrosine kinases that is used to treat RC. Results provide insight into molecular mechanisms underlying acquired sunitinib resistance in RC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 3 disease state, 3 individual sets
Platform:
GPL6244
Series:
GSE66346
9 Samples
Download data: CEL
5.
Full record GDS5812

Staphylococcal alpha-toxin effect on airway epithelial cells

Analysis of bronchial epithelial cell lines 16HBE14o- (Hla-susceptible) and S9 (Hla-resistant) treated with S. aureus recombinant alpha-toxin (rHla) for 2 hrs. Results provide insight into molecular mechanisms underlying cell type-specific responses of airway epithelial cells to alpha-toxin.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 cell line sets
Platform:
GPL6244
Series:
GSE65018
8 Samples
Download data: CEL
6.
Full record GDS5811

TGFβ1 effect on gingival fibroblasts pretreated with TGFβ-associated kinase 1 inhibitor 5Z-7-Oxozeanol

Analysis of cultured gingival fibroblasts pre-treated with TGFβ-associated kinase 1 (TAK1) inhibitor (5Z)-7-Oxozeanol for 45 min prior to treatment with TGFβ1. Results provide insight into the extent to which TAK1 mediates fibroproliferative responses in gingival fibroblasts in response to TGFβ1.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 protocol sets
Platform:
GPL6244
Series:
GSE65069
8 Samples
Download data: CEL
7.
Full record GDS5810

Hypoxia effect on von Hippel Lindau-overexpressing renal cell carcinoma cells

Analysis of renal cell carcinoma (RCC) 786-O cells transfected with von Hippel Lindau (VHL)-overexpression vector and cultured under hypoxia conditions (1% O2) for 24 hours. Results provide insight into overlap and differences of VHL- and hypoxia-dependent molecular alterations in RCC.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 protocol, 2 stress sets
Platform:
GPL6244
Series:
GSE65168
8 Samples
Download data: CEL
8.
Full record GDS5805

Peptidyl-prolyl cis/trans isomerase Pin1 deficiency effect on prostate cancer cells

Analysis of prostate cancer (PC) cell lines LNCap (androgen-dependent) and DU145 (androgen-independent) following siRNA-mediated knockdown of Peptidyl-prolyl cis/trans isomerase Pin1. Results provide insight into molecular mechanisms underlying Pin1 modulation of both PC two cell lines.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 cell line, 3 protocol sets
Platform:
GPL6244
Series:
GSE67457
6 Samples
Download data: CEL
9.
Full record GDS5670

Mesenchymal-to-amoeboid transition effect on Hs294T melanoma cells

Analysis of Hs294T melanoma cells following three different treatments that induce the mesenchymal to amoeboid transition (MAT) in melanoma cells: EphA2 overexpression, Ilomastat treatment, or RhoA activator Calpeptin treatment. Results provide insight into molecular mechanisms underlying MAT.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 protocol sets
Platform:
GPL6244
Series:
GSE52246
8 Samples
Download data: CEL
10.
Full record GDS5659

Rho-associated kinase deficiency effect on coronary artery smooth muscle cells in vitro

Analysis of cultured vascular smooth muscle cells following knockdown of Rho-associated kinase 1 (ROCK1). ROCK1 phosphorylates and activates zipper-interacting protein kinase (ZIPK). These results, together with those from GDSxxxx, provide further insight into ROCK1 and ZIPK functions.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6244
Series:
GSE56819
6 Samples
Download data: CEL
11.
Full record GDS5606

Androgen effect on runt-related transcription factor 1-deficient prostate cancer cell line

Analysis of androgen receptor (AR)-positive prostate cancer (PC) LNCaP cells depleted for runt-related transcription factor (RUNX1) by siRUNX1 transfection then treated with 10nM dihydrotestosterone (DHT). Results provide insight into the role of RUNX1 in AR-dependent PC.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL6244
Series:
GSE62454
4 Samples
Download data: CEL, CHP
12.
Full record GDS5600

Acute myeloid leukemia cell line Kasumi-1 response to dasatinib treatment and withdrawal

Analysis of dasatinib-sensitive, KITmut t(8;21) AML cell line Kasumi-1 treated with dasatinib for 12 wks giving rise to R48 cells. After 1 wk of dasatinib cessation, R48 cells give rise to PR48 cells. Results provide insight into molecular effects of long-term dasatinib treatment on t(8;21) AML.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 3 cell line, 3 protocol sets
Platform:
GPL6244
Series:
GSE39073
9 Samples
Download data: CEL
DataSet
Accession:
GDS5600
ID:
5600
13.
Full record GDS5544

Edelfosine effect on stimulated CD4+ T cells

Analysis of stimulated CD4+ T cells (derived from buffy coat PBMCs) treated with edelfosine at 3.3µg/ml. Edelfosine is a cytotoxic drug taken up by highly proliferating cells such as activated immune cells. Results provide insight into the molecular basis of edelfosine action in immune T cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 protocol sets
Platform:
GPL6244
Series:
GSE44392
12 Samples
Download data: CEL
14.
Full record GDS5496

miR-365 expression effect on lung adenocarcinoma cell line

Analysis of NCI-H441 adenocarcinoma cells expressing hsa-miR-365-2, a precursor of miR-365. Results identify targets of miR-365 and the role of miR-365 in the pulmonary transcriptional program responsible for lung development and malignancy.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 protocol sets
Platform:
GPL6244
Series:
GSE33672
4 Samples
Download data: CEL
15.
Full record GDS5454

Epidermal keratinocyte differentiation in vitro

Analysis of neonatal epidermal keratinocytes treated with 1.8 mM calcium for up to 48 hours. Results provide insight into the molecular mechanisms underlying the differentiation of epidermal keratinocytes.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 7 time sets
Platform:
GPL6244
Series:
GSE38628
14 Samples
Download data: CEL, CHP
16.
Full record GDS5453

GRHL3-depleted epidermal keratinocyte response to the induction of differentiation in vitro

Analysis of Grainyhead like 3 (GRHL3)-depleted neonatal epidermal keratinocytes following treatment with 1.8 mM calcium for 24 hours to induce differentiation. GRHL3 encodes a transcription factor. Results provide insight into the role of GRHL3 in keratinocyte differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL6244
Series:
GSE37049
6 Samples
Download data: CEL, CHP
17.
Full record GDS5452

MLL2-depleted epidermal keratinocyte response to the induction of differentiation in vitro

Analysis of MLL2-depleted neonatal epidermal keratinocytes following treatment with 1.8 mM calcium for 24 hours to induce differentiation. Histone H3K4 methyltransferase MLL2 is a trithorax group protein. Results provide insight into the role of MLL2 in keratinocyte differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL6244
Series:
GSE37570
4 Samples
Download data: CEL, CHP
18.
Full record GDS5440

Androgen effect on carboxyl terminal-binding protein 2-deficient prostate cancer cell line

Analysis of androgen receptor (AR)-positive LNCaP prostate cancer cells depleted for carboxyl terminal-binding protein 2 (CTBP2) then treated with the androgen, dihydrotestosterone (DHT). Results provide insight into the molecular effects of CtBP2 knockdown on AR-mediated gene regulation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 4 genotype/variation sets
Platform:
GPL6244
Series:
GSE58309
10 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS5440
ID:
5440
19.
Full record GDS5427

Osteoarthritic acetabular labrum 3-D culture

Analysis of osteoarthritic labrum cells cultured for 7 days in a 3-dimensional alginate bead system. The acetabular labrum is a fibrocartilaginous structure that seals the hip joint. Results provide insight into hip OA-associated molecular changes in acetabular labrum cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 8 individual sets
Platform:
GPL6244
Series:
GSE60762
8 Samples
Download data: CEL
DataSet
Accession:
GDS5427
ID:
5427
20.
Full record GDS5391

Protein tyrosine kinase PTK7 knockdown effect on lung adenocarcinoma cell lines

Analysis of lung adenocarcinoma (ADC) cell lines NCI-H1299 and NCI-H2009 depleted for protein tyrosine kinase PTK7 using two independent shRNAs (shPTK7-1 and shPTK7-2). Results provide insight into the role of PTK7 in lung ADCs.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 cell line, 4 protocol sets
Platform:
GPL6244
Series:
GSE50138
8 Samples
Download data: CEL
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