Similar studies for GEO DataSets (Select 1951) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 19511.

Analysis of pituitary glands from day 17 embryos and post-hatch day 3 animals using a neuroendocrine system specific cDNA microarray. Major cell types in the anterior pituitary gland have differentiated at embryonic day 17. Results used to validate the method of amplifying RNA from pituitary glands.

Organism:: Gallus gallus

Type:: Expression profiling by array, log2 ratio, 2 age sets

Platform:: GPL1744
Series:: GSE3226
6 Samples

Download data: TIFF

DataSet

Accession:: GDS1951

ID:: 1951

Select item 2000032272.

Global gene expression profiling during pituitary thyrotroph, somatotroph, and lactotroph differentiation.

(Submitter supplied) The anterior pituitary is comprised of five major hormone-secreting cell types which differentiate during embryonic development in a temporally distinct manner. Microarrays containing 5,128 unique cDNAs expressed in the neuroendocrine system were produced and used to identify genes with potential involvement in onset of thyroid-stimulating hormone beta-subunit, growth hormone, and prolactin gene transcription during chick embryonic development. more...

Organism:: Gallus gallus

Type:: Expression profiling by array

Dataset:: GDS1952
Platform:: GPL1744
16 Samples

Download data: TIFF

Series

Accession:: GSE3227

ID:: 200003227

Select item 2000032263.

Changes in pituitary gene expression between embryonic day 17 and post-hatch day 3.

(Submitter supplied) A major research focus in our laboratory is the development of the chicken pituitary gland. As this tissue does not yield sufficient RNA to analyze using cDNA microarrays, mRNA must be amplified by reverse transcription with an oligo-dT primer containing the T7 RNA polymerase promoter site followed by in vitro transcription using T7 RNA polymerase. Therefore, this preliminary study investigating differential gene expression between embryonic day 17, when all the major cell types in the chick anterior pituitary gland have differentiated, and post-hatch day 3 was conducted to verify that amplified antisense RNA could be used in conjunction with our neuroendocrine microarrays containing 5,128 unique cDNAs to detect changes in gene expression. more...

Organism:: Gallus gallus

Type:: Expression profiling by array

Dataset:: GDS1951
Platform:: GPL1744
6 Samples

Download data: TIFF

Series

Accession:: GSE3226

ID:: 200003226

Select item 1000017444.

Chicken_Neuroendocrine_System_5K

(Submitter supplied) Spotted amplified cDNA array on glass. Produced with cDNA clones expressed in the chicken neuroendocrine system. Tissues used to produced the cDNA library included the hypothalamus, anterior pituitary gland, and pineal gland. 7200 spots Keywords = spotted Keywords = cDNA

Organism:: Gallus gallus

2 DataSets
2 Series
22 Samples

Download data

Platform

Accession:: GPL1744

ID:: 100001744

PubMed Similar studies

Select item 19525.

Pituitary gland development

Analysis of embryonic pituitary glands at various ages from day 10 to day 17 using a neuroendocrine system specific cDNA microarray. Results identify genes potentially involved in the onset of thyroid-stimulating hormone beta-subunit, growth hormone, and prolactin gene transcription.

Organism:: Gallus gallus

Type:: Expression profiling by array, log2 ratio, 4 age sets

Platform:: GPL1744
Series:: GSE3227
16 Samples

Download data: TIFF

DataSet

Accession:: GDS1952

ID:: 1952

Select item 2000050676.

Characterization of Glucocorticoid-Induced Changes in Gene Expression in the Embryonic Pituitary Gland.

(Submitter supplied) We have previously shown that corticosterone (CORT) can induce premature differentiation of somatotrophs in the chicken embryo. CORT induction of GH mRNA is indirect, in that protein synthesis inhibition blocks its inducing effect. In this study, we used a custom chicken microarray to analyze global gene expression in the embryonic pituitary gland and to identify potential direct targets of CORT that may regulate its induction of somatotroph differentiation. more...

Organism:: Gallus gallus

Type:: Expression profiling by array

Platform:: GPL1731
48 Samples

Download data

Series

Accession:: GSE5067

ID:: 200005067

Select item 2000107487.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3643
Platform:: GPL1355
24 Samples

Download data: CEL

Series

Accession:: GSE10748

ID:: 200010748

Select item 36438.

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 6 dose sets

Platform:: GPL1355
Series:: GSE10748
24 Samples

Download data: CEL

DataSet

Accession:: GDS3643

ID:: 3643

Select item 2000013729.

Pig peri-implantation embryo development transcriptional profiling

(Submitter supplied) A novel porcine cDNA microarray, containing PCR products selected for embryonic expression, was used for transcriptional profiling during conceptus development. Total RNA from quadruplicate samples of small spherical (1-5mm), large spherical (6-11mm), tubular (13-45mm), and filamentous (>100mm) was extracted, amplified, and converted to 32P labeled target and hybridized to membranes. Porcine peri-implantation embryo development order is from small spherical to large spherical, then to Tubular, then to filamentous. more...

Organism:: Sus scrofa

Type:: Expression profiling by array

Dataset:: GDS844
Platform:: GPL1209
16 Samples

Download data

Series

Accession:: GSE1372

ID:: 200001372

Select item 84410.

Peri-implantation embryo development

Gene expression changes during peri-implantation conceptus development. Small spherical (1-5 mm), large spherical (6-11 mm), tubular (13-45 mm) and filamentous (>100 mm) embryos analyzed.

Organism:: Sus scrofa

Type:: Expression profiling by array, count, 4 development stage sets

Platform:: GPL1209
Series:: GSE1372
16 Samples

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DataSet

Accession:: GDS844

ID:: 844

Select item 20000103611.

Hemin timecourse 0-72h

(Submitter supplied) K562 cells (duplicate cultures A & B) are treated with 50 micromolar hemin for 0, 6, 12, 24, 48, 72 hours followed by RNA extraction and gene expression profiling on Affymetrix human U133A arrays and analysis by MAS 5.0 Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS826
Platform:: GPL96
12 Samples

Download data

Series

Accession:: GSE1036

ID:: 200001036

Select item 82612.

Erythroid differentiation of erythroleukemia cell line induced by hemin: time course

Expression profiling of K562 erythroleukemia cells induced to differentiate into erythroid-like cells by hemin. K562 cells examined at various time points up to 72 hours following treatment with 50 uM hemin. Results provide insight into mechanisms underlying hemoglobinization.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 6 time sets

Platform:: GPL96
Series:: GSE1036
12 Samples

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DataSet

Accession:: GDS826

ID:: 826

Select item 20000505013.

Regulation of 22q11 orthologous genes during mouse development

(Submitter supplied) 22q11-deletion syndrome (22q11DS) is a developmental anomaly caused by a microdeletion on human chromosome 22q11. Although mouse models indicated Tbx1 as the gene responsible of the syndrome, the phenotypic spectrum of del22q11 patients is complex suggesting that gene-gene and gene-environment interactions, probably during embryonic development, are crucial in delineating the pathogenesis of 22q11DS. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL3634
14 Samples

Download data

Series

Accession:: GSE5050

ID:: 200005050

Select item 20000752914.

Two distinct gene signatures identify malignant Neuroblast and Schwannian stromal cells of Neuroblastic Tumors

(Submitter supplied) Tumor tissue heterogeneity is a well known feature of several solid tumors. Neuroblastic Tumors (NTs) is a group of paediatric cancers with a great tissue heterogeneity. Most of NTs are composed of undifferentiated, poorly differentiated or differentiating neuroblastic (Nb) cells with very few or absent Schwannian stromal (SS) cells: these tumors are grouped as Neuroblastoma (Schwannian stroma-poor). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
28 Samples

Download data: CEL

Series

Accession:: GSE7529

ID:: 200007529

Select item 20001079615.

Identification of genes that restrict astrocyte differentiation of midgestational neural precursor cells

(Submitter supplied) During development of the mammalian central nervous system (CNS), neurons and glial cells (astrocytes and oligodendrocytes) are generated from common neural precursor cells (NPCs). However, neurogenesis precedes gliogenesis, which normally commences at later stages of fetal telencephalic development. Astrocyte differentiation of mouse NPCs at embryonic day (E) 14.5 (relatively late gestation) is induced by activation of the transcription factor STAT3, whereas at E11.5 (mid-gestation) NPCs do not differentiate into astrocytes even when stimulated by STAT3-activating cytokines such as leukemia inhibitory factor (LIF). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE10796

ID:: 200010796

Select item 20004613916.

Genome-wide analysis of E17.5 pituitary gland gene expression of control and Insm1 mutant mice

(Submitter supplied) The Insm1 gene encodes a zinc finger factor expressed in many endocrine organs. We show here that Insm1 is required for differentiation of all endocrine cell types in the pituitary. Thus, in Insm1 mutant mice, hormones characteristic of the different pituitary cell types (thyroid, follicle and melanocyte stimulating hormone, adrenocorticotrope hormone, growth hormone and prolactin) are absent or produced at markedly reduced levels. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5066
Platform:: GPL6885
16 Samples

Download data: TXT

Series

Accession:: GSE46139

ID:: 200046139

Select item 506617.

Insm1 deficiency effect on the fetal pituitary gland

Analysis of pituitary glands from embryonic day 17.5 mutants deficient for Insm1. The Insm1 gene encodes a zinc finger factor expressed in many endocrine organs. Results provide insight into the role of Insm1 in the development of the pituitary gland.