GEO DataSets

(Submitter supplied) The local background was subtracted from the fluorescent value of each spot. Feature intensities were extracted from scanned microarray images using GenePix Pro 5.1. (Axon Instruments). The images were visually inspected, and spots from low-quality areas of the array were flagged and excluded from further analysis. Spots were also excluded from analysis if both the combined fluorescent intensity for both channels was less than 1.4 times that of the local background and the pixel-by-pixel correlation coefficient of the spot was less than 0.4. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL1743

5 Samples

Download data

(Submitter supplied) Gene expression profile of the response to chronic constant hypoxia in the heart of adult zebrafish Keywords: Adaptive response to chronic constant hypoxia in the heart

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS2425

Platform:

GPL1319

10 Samples

Download data: CEL, EXP

Analysis of hearts of wild type Tuebingen animals subjected to chronic constant hypoxia.

Organism:

Danio rerio

Type:

Expression profiling by array, count, 2 stress sets

Platform:

GPL1319

Series:

GSE4989

10 Samples

Download data: CEL, EXP

(Submitter supplied) Zinc deficiency is detrimental to organisms highlighting its role as an essential micronutrient contributing to numerous biological processes. To investigate the underlying molecular events invoked by zinc depletion we performed a temporal analysis of transcriptome changes observed within zebrafish gill. This tissue represents a model system for studying ion absorption across polarised cells as it provides a major pathway for fish to acquire zinc directly from water whilst sharing a conserved zinc transporting system with mammals. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL10429

49 Samples

Download data: TXT

(Submitter supplied) Adaptation to hypoxia is a complicated and important physiological course for organisms, but the genetic mechanism underlying the adaptation is not fully understood yet. Tibetan Chicken (T), an indigenous chicken breed in China which inhabit in high areas with an altitude above 2,900 meters. Shouguang Chicken(S) and Dwarf Recessive White Chicken (DRW), two lowland chicken breeds, were used as control groups. more...

Organism:

Gallus gallus

Type:

Expression profiling by array

Platform:

GPL3213

12 Samples

Download data: CEL, CHP

(Submitter supplied) Study of hypoxia-induced differential expression during zebrafish development at gastrulation (shield) and segmentation (8-somite) stages

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL13784

8 Samples

Download data: XYS

(Submitter supplied) In this study, we performed microarray-based expression profiling on liver of zebrafish exposed to 60 mg/L (192?M) arsenic [As(V)] for 8-96 h, to identify global transcriptional programs and biological networks involved in arsenic-induced adaptive responses in vivo. We identified temporal differentially-expressed gene sets which we have grouped into early, late and all-time arsenic-responsive gene sets. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS2249

Platform:

GPL2715

24 Samples

Download data

Analysis of livers of animals at various time points up to 96 hours following exposure to 15 ppm arsenic. Arsenic is an environmental toxicant and carcinogen. Results provide insight into the molecular mechanisms underlying the toxicity and carcinogenicity of arsenic.

Organism:

Danio rerio

Type:

Expression profiling by array, log2 ratio, 2 agent, 4 time sets

Platform:

GPL2715

Series:

GSE3048

24 Samples

Download data

(Submitter supplied) Ectothermic vertebrates are different from mammals that are sensitive to hypothermia and they have to maintain core temperature for survival. Why and how ectothermic animals can survive, grow and reproduce in low temperature have been for a long time a scientifically challenging and important inquiry to biologists. We used a microarray to profile the gill transcriptome in zebrafish (Danio rerio) after exposure to low temperature. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL5182

6 Samples

Download data: CSV, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Danio rerio

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL14875 GPL10816

10 Samples

Download data: BW, TXT

(Submitter supplied) Analysis of gene expression changes in the von Hippel Lindau when mutant compared to wild-type at 4dpf using a whole genome microarray expression profiling. The von Hippel Lindau mutant displays a systemic hypoxic response under normoxic conditions. We performed single-colour microarrays to identify the gene expression changes which underpin the hypoxic phenotype. We used 3 biological replicates from both mutant and control, followed by analysis using Limma to identify significant gene expression changes. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL10816

6 Samples

Download data: TXT

(Submitter supplied) Analysis of the binding sites of Hif-1α in both wild-type and von Hippel Lindau mutant zebrafish lines at 4dpf by ChIP linked next generation sequencing. The von Hippel Lindau mutant displays a systemic hypoxic response under normoxic conditions. Results show the extent of Hif-1α binding to the genome, and provide a basis for analysis of the transcriptional response to genetically induced hypoxia in zebrafish.

Organism:

Danio rerio

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL14875

4 Samples

Download data: BW, TXT

(Submitter supplied) The fish gill is a multifunctional organ containing a variety of specialized cells including respiratory chemoreceptors, neuroepithelial cells (NECs). Although the structure, function and development of the gill have been studied extensively, transcriptomic profiling of individual gill cells is lacking. Using the 10x Genomics Chromium technology, we conducted a single transcriptomic study of cells from distal gill filament of ETvmat2:GFP zebrafish, acclimated to 14 days of normoxia and hypoxia. more...

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20828

3 Samples

Download data: RDS

(Submitter supplied) Retinal ischemia is believed to initiate a series of events that leads to retinal neovascularization observed in several retinal diseases such as diabetetic retinopathy and retinal vein occlusion. Although some molecules such as VEGF and MCP-1 have been implicated in the process, its underlying mechanisms remain elusive. In order to identify genes associated with retinal ischemia, we performed gene expression analyses in retinas of mouse model of oxygen-induced retinopathy using DNA microarray technology.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

9 Samples

Download data: TXT

(Submitter supplied) High altitude environments are characterized by the unique and unavoidable stress of chronic hypoxia. While much is known about gene expression responses to acute or in vitro hypoxia, less is known about the gene expression profiles of animals exposed to systemic chronic hypoxia, such as that experienced at high elevations. Here we simulated the hypoxic environment of two high altitude elevations,and a third chamber recieved ambient Reno air. more...

Organism:

Mus musculus domesticus; Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4929

Platform:

GPL1261

8 Samples

Download data: CEL

Analysis of livers of C57BL/6 males housed for 32 days in chambers that simulated the hypoxic environment of an altitude of 1400, 3000, or 4500 meters. Results provide insight into the molecular mechanisms underlying acclimatization to high altitude hypoxia.

Organism:

Mus musculus; Mus musculus domesticus

Type:

Expression profiling by array, transformed count, 3 stress sets

Platform:

GPL1261

Series:

GSE15891

8 Samples

Download data: CEL