GEO DataSets

(Submitter supplied) Gene expression profile of the response to chronic constant hypoxia in the heart of adult zebrafish Keywords: Adaptive response to chronic constant hypoxia in the heart

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS2425

Platform:

GPL1319

10 Samples

Download data: CEL, EXP

Analysis of hearts of wild type Tuebingen animals subjected to chronic constant hypoxia.

Organism:

Danio rerio

Type:

Expression profiling by array, count, 2 stress sets

Platform:

GPL1319

Series:

GSE4989

10 Samples

Download data: CEL, EXP

(Submitter supplied) Study of hypoxia-induced differential expression during zebrafish development at gastrulation (shield) and segmentation (8-somite) stages

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL13784

8 Samples

Download data: XYS

(Submitter supplied) Chronic constant hypoxia (CCH), such as in pulmonary diseases or high altitude, and chronic intermittent hypoxia (CIH), such as in sleep apnea, can lead to major changes in the heart. The molecular mechanisms underlying these cardiac alterations are not well understood. We hypothesized that analysis on the changes in gene expression could help to delineate such mechanisms. In addition, the differences that can be anticipated between CCH and CIH could be potentially dissected. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1862

18 Samples

Download data

(Submitter supplied) Adaptation to hypoxia is a complicated and important physiological course for organisms, but the genetic mechanism underlying the adaptation is not fully understood yet. Tibetan Chicken (T), an indigenous chicken breed in China which inhabit in high areas with an altitude above 2,900 meters. Shouguang Chicken(S) and Dwarf Recessive White Chicken (DRW), two lowland chicken breeds, were used as control groups. more...

Organism:

Gallus gallus

Type:

Expression profiling by array

Platform:

GPL3213

12 Samples

Download data: CEL, CHP

(Submitter supplied) Ischemic cardiopathy is the leading cause of death in the world, for which efficient regenerative therapy is not currently available. In mammals, after a myocardial infarction episode, the damaged myocardium is replaced by scar tissue featuring collagen deposition and tissue remodelling with negligible cardiomyocyte proliferation. Zebrafish, in contrast, display an extensive regenerative capacity as they are able to restore completely lost cardiac tissue after partial ventricular amputation. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS3623

Platform:

GPL1319

15 Samples

Download data: CEL

Analysis of hearts of zebrafish 1 to 7 days following partial heart amputation. Unlike mammals, zebrafish hearts display an extensive regenerative capacity. Results provide insight into the molecular basis of this regenerative capacity.

Organism:

Danio rerio

Type:

Expression profiling by array, transformed count, 2 protocol, 5 time sets

Platform:

GPL1319

Series:

GSE17993

15 Samples

Download data: CEL

(Submitter supplied) The local background was subtracted from the fluorescent value of each spot. Feature intensities were extracted from scanned microarray images using GenePix Pro 5.1. (Axon Instruments). The images were visually inspected, and spots from low-quality areas of the array were flagged and excluded from further analysis. Spots were also excluded from analysis if both the combined fluorescent intensity for both channels was less than 1.4 times that of the local background and the pixel-by-pixel correlation coefficient of the spot was less than 0.4. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL1743

5 Samples

Download data

(Submitter supplied) Zebrafish (Danio rerio) gutGFP transgenic embryos [Tg(XlEef1a1:GFP)s854] were collected at 4 time points: 2 days post fertilization (dpf), 3, dpf, 4 dpf, 6 dpf. Embryos were dissociated into single cells and sorted by FACS based on GFP expression. RNA was extracted from the different cell populations (Stratagene), amplified (NuGEN Ovation), and hybridized to Affymetrix Zebrafish GeneChips. Keywords: Time course.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL1319

24 Samples

Download data: CEL

(Submitter supplied) To determine cardiac transcription profiles, we collected myocardial samples immediately after institution of cardiopulmonary bypass from acyanotic or cyanotic Tetralogy of Fallot patients undergoing corrective surgery. The transcriptional profile of the mRNA in these samples was measured with gene array technology.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

12 Samples

Download data: CEL, CHP

(Submitter supplied) To determine cardiac transcription profile in cyanotic Tetralogy of Fallot patients, we collected myocardial samples immediately after institution of cardiopulmonary bypass from cyanotic Tetralogy of Fallot patients undergoing corrective surgery. The transcriptional profile of the mRNA in these samples was measured with gene array technology.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

7 Samples

Download data: CEL, CHP

(Submitter supplied) To determine cardiac transcription profile in acyanotic Tetralogy of Fallot patients, we collected myocardial samples immediately after institution of cardiopulmonary bypass from acyanotic Tetralogy of Fallot patients undergoing corrective surgery. The transcriptional profile of the mRNA in these samples was measured with gene array technology.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

5 Samples

Download data: CEL, CHP

(Submitter supplied) We describe here the transcripts induced after infection of zebrafish with viral haemorrhagic septicemia rhabdovirus (VHSV). Two days after infection, differentially expressed transcript levels from selected immune-related zebrafish genes were studied in both fins and internal organs (pooled spleen, head kidney and liver). 

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL17670

16 Samples

Download data: TXT

(Submitter supplied) In order to explore the relative importance of adult zebrafish innate and adaptive immune responses to different kinds of infections, we compared the gene expression profile of VHSV-challenge-survivors, bacterial infection survivors and control non infected zebrafish.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL17670

16 Samples

Download data: TXT

(Submitter supplied) In this study, we determined the effect of chronic consistent hypoxia (CCH) and chronic intermittent hypoxia (CIH) on global gene expression in cortical and hippocampal region of developing mouse brain using long-oligo beadschip arrays. Keywords: Gene expression profile

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3114

Platform:

GPL5402

18 Samples

Download data: TXT

Analysis of brain cortices and hypothalami of developing animals subjected to chronic consistent hypoxia (CCH) or chronic intermittent hypoxia (CIH). Results provide insight into the molecular mechanisms underlying the long-lasting pathological effects of hypoxia on postnatal brain development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 stress, 2 tissue sets

Platform:

GPL5402

Series:

GSE8262

18 Samples

Download data

(Submitter supplied) The zebrafish (Danio rerio) embryo toxicity test (DarT) is considered as an alternative to the acute fish toxicity test. However, DarT rarely reveals information on the mechanisms underlying a toxic effect and is relatively insensitive compared to chronic toxic effects. We hypothesized that, by using gene expression profiles as an additional endpoint, it may be possible to increase the sensitivity and predictive value of DarT. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL4518

6 Samples

Download data: MEV

(Submitter supplied) Very little is known on the nature of epigenetic states in developing zebrafish despite its growing importance as a model organism in developmental biology. We report histone modifications on promoters of pluripotency genes in zebrafish embryos at the mid-late blastula transition (MBT+) stage. We identify three classes of expressed genes based on these profiles: (1) those with a promoter occupied by marks of active genes without any repressive marks; (2) those co-occupied by both activating and repressive modifications; of these genes, klf4 was notably found to be mosaically expressed in the embryo, possibly accounting for this epigenetic pattern; (3) those occupied by repressive marks with, surprisingly, little not acetylated H3K9 or H4. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL9998

7 Samples

Download data: TXT

(Submitter supplied) Experiment exposed adult male zebrafish to 10ng/L 17-alpha ethinylestradiol for three weeks. Gene expression profiling of liver and telencephalon following exposure. Keywords: estrogenic exposure

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL3548

8 Samples

Download data

(Submitter supplied) Zinc deficiency is detrimental to organisms highlighting its role as an essential micronutrient contributing to numerous biological processes. To investigate the underlying molecular events invoked by zinc depletion we performed a temporal analysis of transcriptome changes observed within zebrafish gill. This tissue represents a model system for studying ion absorption across polarised cells as it provides a major pathway for fish to acquire zinc directly from water whilst sharing a conserved zinc transporting system with mammals. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL10429

49 Samples

Download data: TXT