GEO DataSets

Analysis of six melanoma cell lines treated with the DNA methylation inhibitor 5-aza-2'-deoxycytidine (5AzadC). Results provide insight into the role of epigenetic silencing by DNA methylation in the pathogenesis of melanoma.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 7 cell line, 2 disease state sets

Platform:

GPL96

Series:

GSE9118

14 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) Malignant melanoma is a common and frequently lethal disease. Current therapeutic interventions have little effect on survival, emphasizing the need for a better understanding of the genetic, epigenetic, and phenotypic changes in melanoma formation and progression. We identified genes that were not previously known to be silenced by methylation in melanoma using a microarray-based screen following treatment of melanoma cell lines with the DNA methylation inhibitor 5-Aza-2'-deoxycytidine. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3012

Platform:

GPL96

14 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) Melanoma progression model:DAC-mediated gene expression Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1440

Platform:

GPL80

6 Samples

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(Submitter supplied) Melanoma progression model Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

6 Samples

Download data

Analysis of a poorly tumorigenic melanoma cell line and its 3 highly aggressive derivative lines after treatment with 2'-deoxy-5-azacytidine (DAC), a DNA methyltransferase inhibitor. Results suggest multiple markers for melanoma progression that are regulated by DNA methylation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 4 cell line, 2 cell type sets

Platform:

GPL80

Series:

GSE1793

6 Samples

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(Submitter supplied) Epigenetic regulation of tumor suppressor genes (TSGs) has been shown to play a central role in melanomagenesis. Integrating gene expression and methylation array analysis we identified novel candidate TSGs frequently methylated in melanoma. We validated the methylation status of the most promising TSGs using the highly sensitive, specific and comprehensive Sequenom Epityper assay in a large panel of melanoma cell lines and resected melanomas, and compared the findings with that from cultured melanocytes. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL8490

12 Samples

Download data: TXT