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lrp4 low density lipoprotein receptor-related protein 4 [ Danio rerio (zebrafish) ]

Gene ID: 110351181, updated on 25-Apr-2024

Summary

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Official Symbol
lrp4provided by ZNC
Official Full Name
low density lipoprotein receptor-related protein 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-130129-1
See related
Ensembl:ENSDARG00000116353 AllianceGenome:ZFIN:ZDB-GENE-130129-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
eni; nui
Summary
Predicted to enable calcium ion binding activity. Acts upstream of or within axon regeneration; establishment of synaptic specificity at neuromuscular junction; and neuromuscular synaptic transmission. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including actinotrichium; adaxial cell; caudal vein plexus; median fin fold; and nervous system. Used to study bone development disease. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71850013..71996585)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene myosin, light chain 12, genome duplicate 1 Neighboring gene calcium channel, voltage-dependent, beta 2a Neighboring gene NOP2/Sun RNA methyltransferase 6 Neighboring gene proteasome 26S subunit, non-ATPase 9 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007118.7 Chromosome 7 Reference GRCz11 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish ennui behavioral mutation disrupts acetylcholine receptor localization and motor axon stability. Saint-Amant L, et al. Dev Neurobiol, 2008 Jan. PMID 17918238
  2. The synaptic receptor Lrp4 promotes peripheral nerve regeneration. Gribble KD, et al. Nat Commun, 2018 Jun 19. PMID 29921864, Free PMC Article
  3. Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle. Walker LJ, et al. Development, 2021 Nov 1. PMID 34714331, Free PMC Article
  4. Diverging roles for Lrp4 and Wnt signaling in neuromuscular synapse development during evolution. Remédio L, et al. Genes Dev, 2016 May 1. PMID 27151977, Free PMC Article
  5. Lrp13 is a novel vertebrate lipoprotein receptor that binds vitellogenins in teleost fishes. Reading BJ, et al. J Lipid Res, 2014 Nov. PMID 25217480, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle.
    Title: Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle.
  2. The lrp4 knockdown in zebrafish embryos exhibits cyst formations at fin structures and the caudal vein plexus, malformed pectoral fins, defective bone formation and compromised kidney morphogenesis; which partially phenocopied the human LRP4 mutations and were reminiscent of phenotypes resulting form a perturbed Notch signaling pathway.
    Title: Deficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged-Notch signaling in fin and limb development.
  3. Data show that low density lipoprotein receptor-related protein 4 (Lrp4) coordinates the realignment of denervated Schwann cells with regenerating axons.
    Title: The synaptic receptor Lrp4 promotes peripheral nerve regeneration.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of synaptic specificity at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 4
Names
LDL receptor related protein 4
ennui

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    71850013..71996585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017357153.2 → XP_017212642.2  low-density lipoprotein receptor-related protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z1W5
    Conserved Domains (9) summary
    smart00192
    Location:111 → 143
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:507 → 547
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:397 → 436
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:272 → 306
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:1090 → 1128
    NHL; NHL repeat [structural motif]
    pfam00057
    Location:72 → 107
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:1184 → 1224
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl18310
    Location:1090 → 1282
    NHL; NHL repeat unit of beta-propeller proteins
    pfam14670
    Location:1011 → 1048
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. NM_001351714.1 → NP_001338643.1  

    Conserved Domains (3) summary
    smart00135
    Location:496 → 538
    LY; Low-density lipoprotein-receptor YWTD domain
    pfam00058
    Location:255 → 295
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:158 → 195
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001351714.1: Suppressed sequence

    Description
    NM_001351714.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: LRP4 (GeneID:4038).
Nucleotide Protein Strain
Heading Accession and Version

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