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Map4 microtubule-associated protein 4 [ Mus musculus (house mouse) ]

Gene ID: 17758, updated on 5-Jan-2022

Summary

Official Symbol
Map4provided by MGI
Official Full Name
microtubule-associated protein 4provided by MGI
Primary source
MGI:MGI:97178
See related
Ensembl:ENSMUSG00000032479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAP-4; Mtap4; Mtap-4; AA407148
Summary
Enables microtubule binding activity. Involved in microtubule cytoskeleton organization. Acts upstream of or within establishment of spindle orientation; microtubule sliding; and mitotic spindle organization. Located in postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; gut; musculature; and trunk mesenchyme. Orthologous to human MAP4 (microtubule associated protein 4). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in cerebellum adult (RPKM 29.3), frontal lobe adult (RPKM 18.1) and 28 other tissues See more
Orthologs
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Genomic context

See Map4 in Genome Data Viewer
Location:
9 F2; 9 59.83 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109758909..109913022)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109929841..110083954)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (109834278..109986451)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 25A Neighboring gene microRNA 7089 Neighboring gene predicted gene 4644 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 30 Neighboring gene predicted gene 10615 Neighboring gene predicted gene, 23377

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axoneme ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microtubule-associated protein 4
Names
MAP 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205330.1NP_001192259.1  microtubule-associated protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001192259.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1).
    Source sequence(s)
    AC161246
    Consensus CDS
    CCDS57704.1
    UniProtKB/Swiss-Prot
    P27546
    Related
    ENSMUSP00000035055.11, ENSMUST00000035055.15
    Conserved Domains (1) summary
    pfam00418
    Location:965994
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. NM_001205331.1NP_001192260.1  microtubule-associated protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001192260.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC161246, AK046825
    Consensus CDS
    CCDS57703.1
    UniProtKB/TrEMBL
    Q78TF3
    Related
    ENSMUSP00000131660.3, ENSMUST00000169851.8
  3. NM_001205332.1NP_001192261.1  microtubule-associated protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001192261.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC161246, BC050893
    UniProtKB/Swiss-Prot
    P27546
    Conserved Domains (1) summary
    pfam00418
    Location:927956
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  4. NM_001311163.1NP_001298092.1  microtubule-associated protein 4 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and has multiple coding region differences, including use of an alternate translation initiation site compared to variant 1. It encodes isoform 5, which is shorter than and has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK146790, BB526067, BC042645, BY125595
    Consensus CDS
    CCDS81082.1
    UniProtKB/Swiss-Prot
    P27546
    UniProtKB/TrEMBL
    E9PZ43
    Related
    ENSMUSP00000131285.4, ENSMUST00000164930.8
    Conserved Domains (1) summary
    pfam00418
    Location:774803
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  5. NM_001311164.1NP_001298093.1  microtubule-associated protein 4 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' and 3' UTRs and has multiple coding region differences, including use of an alternate translation initiation site compared to variant 1. It encodes isoform 6, which is shorter than and has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK166558, BB526067, BC042645, BY125595
    Consensus CDS
    CCDS81083.1
    UniProtKB/Swiss-Prot
    P27546
    UniProtKB/TrEMBL
    A0A0G2JDN7
    Related
    ENSMUSP00000142439.2, ENSMUST00000199498.5
    Conserved Domains (1) summary
    pfam00418
    Location:774803
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  6. NM_008633.4NP_032659.2  microtubule-associated protein 4 isoform 2

    See identical proteins and their annotated locations for NP_032659.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is the same length as isoform 1.
    Source sequence(s)
    AC161246, BC044654
    UniProtKB/Swiss-Prot
    P27546
    Conserved Domains (1) summary
    pfam00418
    Location:965994
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    109758909..109913022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244102.1XP_030099962.1  microtubule-associated protein 4 isoform X9

    Conserved Domains (3) summary
    PHA03247
    Location:532828
    PHA03247; large tegument protein UL36; Provisional
    pfam05109
    Location:6871042
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:891920
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. XM_036154653.1XP_036010546.1  microtubule-associated protein 4 isoform X11

    Conserved Domains (2) summary
    PHA03307
    Location:545884
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:891921
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  3. XM_036154656.1XP_036010549.1  microtubule-associated protein 4 isoform X14

    Conserved Domains (2) summary
    pfam05109
    Location:5961004
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:853883
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  4. XM_036154660.1XP_036010553.1  microtubule-associated protein 4 isoform X18

    Conserved Domains (2) summary
    PHA03307
    Location:545849
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:853883
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  5. XM_036154661.1XP_036010554.1  microtubule-associated protein 4 isoform X19

    Conserved Domains (2) summary
    PHA03307
    Location:545849
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:853883
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  6. XM_036154662.1XP_036010555.1  microtubule-associated protein 4 isoform X20

    Conserved Domains (2) summary
    PHA03307
    Location:545849
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:853883
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  7. XM_036154663.1XP_036010556.1  microtubule-associated protein 4 isoform X25

    Conserved Domains (2) summary
    PHA03307
    Location:545849
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:853883
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  8. XM_036154652.1XP_036010545.1  microtubule-associated protein 4 isoform X10

    Conserved Domains (2) summary
    PHA03307
    Location:545884
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:891921
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  9. XM_036154657.1XP_036010550.1  microtubule-associated protein 4 isoform X15

    Conserved Domains (2) summary
    PHA03307
    Location:545849
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:853883
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  10. XM_036154658.1XP_036010551.1  microtubule-associated protein 4 isoform X16

    Conserved Domains (2) summary
    PHA03307
    Location:545849
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:853883
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  11. XM_036154659.1XP_036010552.1  microtubule-associated protein 4 isoform X17

    Conserved Domains (2) summary
    PHA03307
    Location:545849
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:853883
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  12. XM_006511955.3XP_006512018.1  microtubule-associated protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006512018.1

    Conserved Domains (2) summary
    PHA03247
    Location:593903
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:965994
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  13. XM_036154649.1XP_036010542.1  microtubule-associated protein 4 isoform X6

    Conserved Domains (2) summary
    PHA03247
    Location:593903
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:927957
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  14. XM_036154648.1XP_036010541.1  microtubule-associated protein 4 isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:593903
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:927957
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  15. XM_036154645.1XP_036010538.1  microtubule-associated protein 4 isoform X2

    Related
    ENSMUSP00000132662.4, ENSMUST00000165876.8
    Conserved Domains (2) summary
    PHA03247
    Location:593903
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:965995
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  16. XM_036154647.1XP_036010540.1  microtubule-associated protein 4 isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:593903
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:965995
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  17. XM_036154655.1XP_036010548.1  microtubule-associated protein 4 isoform X13

    Conserved Domains (2) summary
    PHA03247
    Location:593903
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:927957
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  18. XM_036154646.1XP_036010539.1  microtubule-associated protein 4 isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:593903
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:965995
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  19. XM_036154654.1XP_036010547.1  microtubule-associated protein 4 isoform X12

    Conserved Domains (2) summary
    PHA03247
    Location:593903
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:927957
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  20. XM_036154650.1XP_036010543.1  microtubule-associated protein 4 isoform X7

    Conserved Domains (2) summary
    PHA03247
    Location:593903
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:927957
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  21. XM_030244101.2XP_030099961.1  microtubule-associated protein 4 isoform X8

    Conserved Domains (2) summary
    PHA03247
    Location:593903
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:927956
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  22. XM_006511960.4XP_006512023.1  microtubule-associated protein 4 isoform X21

    Conserved Domains (2) summary
    PHA03247
    Location:516750
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:812841
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  23. XM_017313175.3XP_017168664.1  microtubule-associated protein 4 isoform X23

    Conserved Domains (2) summary
    PHA03247
    Location:516750
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:812841
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  24. XM_017313176.3XP_017168665.1  microtubule-associated protein 4 isoform X24

    Conserved Domains (2) summary
    PHA03247
    Location:516750
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:812841
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  25. XM_036154664.1XP_036010557.1  microtubule-associated protein 4 isoform X26

    Conserved Domains (2) summary
    PHA03247
    Location:516750
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:812842
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  26. XM_036154665.1XP_036010558.1  microtubule-associated protein 4 isoform X27

    Conserved Domains (2) summary
    PHA03247
    Location:516750
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:774804
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  27. XM_017313178.3XP_017168667.1  microtubule-associated protein 4 isoform X29

    Conserved Domains (2) summary
    PHA03247
    Location:516750
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:774803
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  28. XM_036154667.1XP_036010560.1  microtubule-associated protein 4 isoform X30

    Conserved Domains (2) summary
    PHA03247
    Location:516750
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:774804
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  29. XM_006511962.5XP_006512025.1  microtubule-associated protein 4 isoform X31

    Conserved Domains (2) summary
    PHA03247
    Location:516750
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:774803
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  30. XM_006511964.4XP_006512027.1  microtubule-associated protein 4 isoform X32

    Conserved Domains (2) summary
    pfam05109
    Location:528889
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:738767
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  31. XM_017313179.2XP_017168668.1  microtubule-associated protein 4 isoform X34

    Conserved Domains (2) summary
    pfam05109
    Location:528888
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:738767
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  32. XM_017313180.2XP_017168669.1  microtubule-associated protein 4 isoform X35

    Conserved Domains (2) summary
    pfam05109
    Location:528871
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:738767
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  33. XM_017313181.2XP_017168670.1  microtubule-associated protein 4 isoform X36

    Conserved Domains (2) summary
    pfam05109
    Location:499851
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:700729
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  34. XM_017313183.2XP_017168672.1  microtubule-associated protein 4 isoform X38

    Conserved Domains (2) summary
    pfam05109
    Location:499851
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:700729
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  35. XM_017313185.3XP_017168674.1  microtubule-associated protein 4 isoform X40

    Conserved Domains (2) summary
    pfam00418
    Location:700729
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam17823
    Location:532687
    DUF5585; Family of unknown function (DUF5585)
  36. XM_017313184.2XP_017168673.1  microtubule-associated protein 4 isoform X39

    Conserved Domains (2) summary
    pfam05109
    Location:499850
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:700729
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  37. XM_017313186.2XP_017168675.1  microtubule-associated protein 4 isoform X41

    Conserved Domains (2) summary
    pfam00418
    Location:700729
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam17823
    Location:532687
    DUF5585; Family of unknown function (DUF5585)
  38. XM_036154669.1XP_036010562.1  microtubule-associated protein 4 isoform X42

    Conserved Domains (2) summary
    pfam05109
    Location:499820
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:700730
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  39. XM_017313187.2XP_017168676.1  microtubule-associated protein 4 isoform X43

    Conserved Domains (2) summary
    pfam05109
    Location:499819
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:700729
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  40. XM_017313188.2XP_017168677.1  microtubule-associated protein 4 isoform X44

    Conserved Domains (2) summary
    pfam05109
    Location:499819
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:700729
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  41. XM_017313174.3XP_017168663.1  microtubule-associated protein 4 isoform X22

    Conserved Domains (2) summary
    PHA03247
    Location:516750
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:812841
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  42. XM_036154668.1XP_036010561.1  microtubule-associated protein 4 isoform X33

    Conserved Domains (2) summary
    pfam05109
    Location:528888
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:738768
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  43. XM_017313182.3XP_017168671.1  microtubule-associated protein 4 isoform X37

    Conserved Domains (2) summary
    pfam05109
    Location:499850
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:700729
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  44. XM_017313177.3XP_017168666.1  microtubule-associated protein 4 isoform X28

    Conserved Domains (2) summary
    PHA03247
    Location:516750
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:774803
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
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