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AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) [ Canis lupus familiaris (dog) ]

Gene ID: 497070, updated on 11-Apr-2024

Summary

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Gene symbol
AKR1C3
Gene description
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
See related
Ensembl:ENSCAFG00845002994
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
PGFS
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Genomic context

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See AKR1C3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (31042072..31071570)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (27694812..27719595)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (29696602..29721383)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (28135405..28160172)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (28972376..28997157)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene urocortin 3 Neighboring gene uncharacterized LOC119870172 Neighboring gene aldo-keto reductase family 1 member E2 Neighboring gene uncharacterized LOC102156268

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of prostaglandins in reproductive physiology. Bardin TP. Ohio State Med J, 1970 Oct. PMID 4918753
  2. Biosynthesis and degradation of canine placental prostaglandins: prepartum changes in expression and function of prostaglandin F2α-synthase (PGFS, AKR1C3) and 15-hydroxyprostaglandin dehydrogenase (HPGD). Gram A, et al. Biol Reprod, 2013 Jul. PMID 23677986
  3. Canine prostaglandin F2alpha receptor (FP) and prostaglandin F2alpha synthase (PGFS): molecular cloning and expression in the corpus luteum. Kowalewski MP, et al. Anim Reprod Sci, 2008 Aug. PMID 17689894

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. utero/placental expression identified in the superficial uterine glands throughout gestation and in the trophoblast cells within the feto-maternal contact zone during placentation
    Title: Biosynthesis and degradation of canine placental prostaglandins: prepartum changes in expression and function of prostaglandin F2α-synthase (PGFS, AKR1C3) and 15-hydroxyprostaglandin dehydrogenase (HPGD).
  2. The cloning and expression of prostaglandin F2alpha receptor (FP) and prostaglandin F2alpha synthase (PGFS)in the canine corpus luteum in nonpregnant dogs during diestrus are reported.[PF; PGFS]
    Title: Canine prostaglandin F2alpha receptor (FP) and prostaglandin F2alpha synthase (PGFS): molecular cloning and expression in the corpus luteum.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables androsterone dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables bile acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ketosteroid monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in daunorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in doxorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in progesterone metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
aldo-keto reductase family 1 member C21
Names
prostaglandin F synthase
NP_001012344.1
XP_038513775.1
XP_038513776.1
XP_038513777.1
XP_038513778.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012344.1 → NP_001012344.1  aldo-keto reductase family 1 member C21

    See identical proteins and their annotated locations for NP_001012344.1

    Status: PROVISIONAL

    Source sequence(s)
    AY875970
    UniProtKB/TrEMBL
    A0A8C0LYD8, A0A8C0M3N9, Q5FYA7
    Related
    ENSCAFP00845004208.1, ENSCAFT00845005292.1
    Conserved Domains (2) summary
    COG0656
    Location:9 → 306
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:4 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    31042072..31071570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038657848.1 → XP_038513776.1  aldo-keto reductase family 1 member C21 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JT19, A0A8C0M3N9, A0A8C0PUD9, A0A8I3MRB2
    Conserved Domains (1) summary
    cd19108
    Location:7 → 308
    AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

  2. XM_038657847.1 → XP_038513775.1  aldo-keto reductase family 1 member C21 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JT19, A0A8C0M3N9, A0A8C0PUD9, A0A8I3MRB2
    Conserved Domains (1) summary
    cd19108
    Location:7 → 308
    AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

  3. XM_038657850.1 → XP_038513778.1  aldo-keto reductase family 1 member C21 isoform X3

    UniProtKB/TrEMBL
    A0A8C0M3N9
    Conserved Domains (1) summary
    cl00470
    Location:1 → 254
    AKR_SF; Aldo-keto reductase (AKR) superfamily

  4. XM_038657849.1 → XP_038513777.1  aldo-keto reductase family 1 member C21 isoform X2

    UniProtKB/TrEMBL
    A0A8C0M3N9, A0A8C0RVJ1
    Conserved Domains (1) summary
    cd19108
    Location:8 → 286
    AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    28135405..28160172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    28972376..28997157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    29696602..29721383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    27694812..27719595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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