myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myhz1.1provided by ZNC
Official Full Name: myosin, heavy polypeptide 1.1, skeletal muscleprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000322-5
See related: Ensembl:ENSDARG00000067990 AllianceGenome:ZFIN:ZDB-GENE-000322-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb20; myhc3; myhc4; myhz1; fb37e12; myo2hc1; sb:cb20; fmyhc1.1; wu:fb26a08; wu:fb26f12; wu:fb37e12; etID37302.5; si:ch211-158m24.7
Summary: Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Acts upstream of or within somite specification. Predicted to be part of myosin complex. Is expressed in several structures, including adaxial cell; brain; eye; musculature system; and somite. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; disease of cellular proliferation; and distal arthrogryposis (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1) and MYH8 (myosin heavy chain 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (32298624..32309131, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (31698471..31708978, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI437080 (e-PCR)
- UniSTS:206592

fi38g05.x1 (e-PCR)
- UniSTS:197430

fb26a08 (e-PCR)
- UniSTS:188996

fi17f08.x1 (e-PCR)
- UniSTS:196933

fb26f12 (e-PCR)
- UniSTS:189003

h56846 (e-PCR)
- UniSTS:186965

fd14a01.x1 (e-PCR)
- UniSTS:204157

fb54g09.y1 (e-PCR)
- UniSTS:190714

aa566396 (e-PCR)
- UniSTS:186878

aa566432 (e-PCR)
- UniSTS:186879

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somite specification	IEP Inferred from Expression Pattern more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin, heavy polypeptide 1.1, skeletal muscle

Names: fast MyHC; myosin, heavy polypeptide 1, skeletal muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115089.2 → NP_001108561.1 myosin, heavy polypeptide 1.1, skeletal muscle

See identical proteins and their annotated locations for NP_001108561.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BX510649

UniProtKB/TrEMBL

A0A8M1NI19, B8A568

Related

ENSDARP00000105831.2, ENSDART00000123003.3

Conserved Domains (7) summary

cd01377
Location:101 → 768

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:89 → 768

Myosin_head; Myosin head (motor domain)

pfam01576
Location:848 → 1925

Myosin_tail_1; Myosin tail

pfam02736
Location:36 → 74

Myosin_N; Myosin N-terminal SH3-like domain

pfam07851
Location:1473 → 1583

TMPIT; TMPIT-like protein

cl00459
Location:1297 → 1409

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl02488
Location:881 → 1043

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001130666.2 → NP_001124138.2 myosin, heavy polypeptide 1.1, skeletal muscle

See identical proteins and their annotated locations for NP_001124138.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BX510649

UniProtKB/TrEMBL

A0A8M1NI19, B8A568

Related

ENSDARP00000152470.1, ENSDART00000193758.1

Conserved Domains (7) summary

cd01377
Location:101 → 768

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:89 → 768

Myosin_head; Myosin head (motor domain)

pfam01576
Location:848 → 1925

Myosin_tail_1; Myosin tail

pfam02736
Location:36 → 74

Myosin_N; Myosin N-terminal SH3-like domain

pfam07851
Location:1473 → 1583

TMPIT; TMPIT-like protein

cl00459
Location:1297 → 1409

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl02488
Location:881 → 1043

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...