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    Cntrl centriolin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311886, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Cntrlprovided by RGD
    Official Full Name
    centriolinprovided by RGD
    Primary source
    RGD:1305317
    See related
    Ensembl:ENSRNOG00000022015 AllianceGenome:RGD:1305317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cep1; Cep110
    Summary
    Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in regulation of cytoskeleton organization. Predicted to act upstream of or within circulatory system development and kidney development. Predicted to be located in cytosol; microtubule cytoskeleton; and perinuclear region of cytoplasm. Predicted to be part of centriolar subdistal appendage. Predicted to be active in microtubule organizing center. Orthologous to human CNTRL (centriolin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 173.1), Spleen (RPKM 138.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cntrl in Genome Data Viewer
    Location:
    3p11
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (38825575..38897835)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (18428147..18500362)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (14299441..14371681)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486354 Neighboring gene complement C5 like 1 Neighboring gene RAB14, member RAS oncogene family Neighboring gene uncharacterized LOC102554040

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a cDNA encoding an antigen which is salt-stably attached to centrosomes. Angiolillo A, et al. Biochim Biophys Acta, 1996 Dec 11. PMID 8982254
    2. Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. Jurczyk A, et al. J Cell Biol, 2004 Aug 30. PMID 15337773, Free PMC Article
    3. A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation. Chen CT, et al. Curr Biol, 2014 Oct 6. PMID 25220058, Free PMC Article
    4. 3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Sonnen KF, et al. Biol Open, 2012 Oct 15. PMID 23213374, Free PMC Article
    5. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of centriolar subdistal appendage ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in meiotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in meiotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centriolin
    Names
    centrosomal protein 1
    centrosomal protein 110
    centrosomal protein 110kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427179.1 → NP_001414108.1  centriolin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A1B0GWU0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      38825575..38897835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106229.2 → XP_038962157.1  centriolin isoform X2

      Conserved Domains (6) summary
      PTZ00108
      Location:267 → 535
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR02168
      Location:1395 → 2214
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam06346
      Location:1237 → 1299
      Drf_FH1; Formin Homology Region 1
      cd21340
      Location:89 → 261
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_039106231.2 → XP_038962159.1  centriolin isoform X4

      Conserved Domains (6) summary
      PTZ00108
      Location:267 → 535
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR02168
      Location:1336 → 2155
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam06346
      Location:1178 → 1240
      Drf_FH1; Formin Homology Region 1
      cd21340
      Location:89 → 261
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    3. XM_039106230.2 → XP_038962158.1  centriolin isoform X3

      Conserved Domains (6) summary
      PTZ00108
      Location:267 → 538
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR02168
      Location:1384 → 2203
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam06346
      Location:1226 → 1288
      Drf_FH1; Formin Homology Region 1
      cd21340
      Location:89 → 261
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    4. XM_063283970.1 → XP_063140040.1  centriolin isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWU0

    5. XM_039106233.2 → XP_038962161.1  centriolin isoform X5

      UniProtKB/TrEMBL
      A6JUE6
      Conserved Domains (7) summary
      COG1196
      Location:1400 → 2080
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:267 → 535
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR02168
      Location:438 → 1120
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam06346
      Location:1238 → 1300
      Drf_FH1; Formin Homology Region 1
      cd21340
      Location:89 → 261
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    6. XM_063283971.1 → XP_063140041.1  centriolin isoform X6

      UniProtKB/TrEMBL
      A6JUE6

    7. XM_039106235.2 → XP_038962163.1  centriolin isoform X7

      Conserved Domains (5) summary
      PTZ00108
      Location:267 → 535
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR02168
      Location:438 → 1120
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:89 → 261
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    8. XM_039106227.2 → XP_038962155.1  centriolin isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWU0
      Conserved Domains (6) summary
      PTZ00108
      Location:267 → 535
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR02168
      Location:1396 → 2215
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam06346
      Location:1238 → 1300
      Drf_FH1; Formin Homology Region 1
      cd21340
      Location:89 → 261
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107836.1: Suppressed sequence

      Description
      NM_001107836.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: CEP110 (GeneID:11064).
    Nucleotide Protein Strain
    Heading Accession and Version

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