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    Clip2 CAP-GLY domain containing linker protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 269713, updated on 12-May-2024

    Summary

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    Official Symbol
    Clip2provided by MGI
    Official Full Name
    CAP-GLY domain containing linker protein 2provided by MGI
    Primary source
    MGI:MGI:1313136
    See related
    Ensembl:ENSMUSG00000063146 AllianceGenome:MGI:1313136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clip1; Cyln2; WSCR4; wbscr4; CLIP-115; mKIAA0291; B230327O20
    Summary
    Enables microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Located in microtubule plus-end. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; limb; and trigeminal nerve. Used to study Williams-Beuren syndrome. Orthologous to human CLIP2 (CAP-Gly domain containing linker protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 28.5), CNS E18 (RPKM 28.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G2; 5 74.63 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134518237..134582922, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134489383..134553767, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene general transcription factor II I repeat domain-containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:134920313-134920568 Neighboring gene STARR-seq mESC enhancer starr_14545 Neighboring gene STARR-seq mESC enhancer starr_14546 Neighboring gene ribosomal protein S28 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11305 Neighboring gene STARR-positive B cell enhancer ABC_E9653 Neighboring gene STARR-positive B cell enhancer ABC_E3628 Neighboring gene syncytin a Neighboring gene microRNA 7228 Neighboring gene replication factor C (activator 1) 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. History-dependent catastrophes regulate axonal microtubule behavior. Stepanova T, et al. Curr Biol, 2010 Jun 8. PMID 20471267
    2. Contribution of CYLN2 and GTF2IRD1 to neurological and cognitive symptoms in Williams Syndrome. van Hagen JM, et al. Neurobiol Dis, 2007 Apr. PMID 17270452
    3. Of mice and (wo)men: genotype-phenotype correlations in BRCA1. Hohenstein P, et al. Hum Mol Genet, 2003 Oct 15. PMID 12915453
    4. Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-alpha. Funakoshi H, et al. Am J Physiol Heart Circ Physiol, 2002 Jun. PMID 12003824
    5. The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region. Hoogenraad CC, et al. Genomics, 1998 Nov 1. PMID 9799601

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Williams Syndrome is caused by a variety of genes and that heterozygous deletion of CYLN2 is one of the major causes
      Title: Contribution of CYLN2 and GTF2IRD1 to neurological and cognitive symptoms in Williams Syndrome.
    2. evidence that mice with haploinsufficiency for Cyln2 have features reminiscent of Williams syndrome, including mild growth deficiency, brain abnormalities, hippocampal dysfunction and particular deficits in motor coordination
      Title: Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellar body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CAP-Gly domain-containing linker protein 2
    Names
    cytoplasmic linker protein 1, 115 kDa
    cytoplasmic linker protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039162.2 → NP_001034251.1  CAP-Gly domain-containing linker protein 2 isoform b

      See identical proteins and their annotated locations for NP_001034251.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.
      Source sequence(s)
      BC053048, BC121191
      Consensus CDS
      CCDS39309.1
      UniProtKB/TrEMBL
      Q6A090
      Related
      ENSMUSP00000037431.7, ENSMUST00000036999.10
      Conserved Domains (4) summary
      TIGR04527
      Location:537 → 623
      mycoplas_twoTM; two transmembrane protein
      pfam01302
      Location:223 → 286
      CAP_GLY; CAP-Gly domain
      pfam10212
      Location:648 → 836
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein
      pfam13863
      Location:358 → 452
      DUF4200; Domain of unknown function (DUF4200)

    2. NM_009990.3 → NP_034120.2  CAP-Gly domain-containing linker protein 2 isoform a

      See identical proteins and their annotated locations for NP_034120.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK045967, BC053048, BC121191
      Consensus CDS
      CCDS39310.1
      UniProtKB/Swiss-Prot
      Q7TSI9, Q8CHU1, Q9EP81, Q9Z0H8
      UniProtKB/TrEMBL
      Q6A090
      Related
      ENSMUSP00000098212.3, ENSMUST00000100647.7
      Conserved Domains (2) summary
      COG1196
      Location:357 → 1016
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:222 → 286
      CAP_GLY; CAP-Gly domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      134518237..134582922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165158.1 → XP_036021051.1  CAP-Gly domain-containing linker protein 2 isoform X1

      Conserved Domains (2) summary
      COG5244
      Location:220 → 853
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:222 → 286
      CAP_GLY; CAP-Gly domain

    RNA

    1. XR_004942523.1 RNA Sequence

    2. XR_003955655.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0H8.2 GenPept UniProtKB/Swiss-Prot:Q9Z0H8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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