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    Ttc28 tetratricopeptide repeat domain 28 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304558, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ttc28provided by RGD
    Official Full Name
    tetratricopeptide repeat domain 28provided by RGD
    Primary source
    RGD:1594541
    See related
    Ensembl:ENSRNOG00000032590 AllianceGenome:RGD:1594541
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable kinase binding activity. Predicted to be involved in regulation of mitotic cell cycle. Predicted to be located in midbody. Orthologous to human TTC28 (tetratricopeptide repeat domain 28). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 47.4), Lung (RPKM 46.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttc28 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (51002816..51443461, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (45342986..45783968, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (51385808..51840710, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481215 Neighboring gene phosphatidylinositol transfer protein, beta Neighboring gene uncharacterized LOC134481214 Neighboring gene uncharacterized LOC102554233 Neighboring gene uncharacterized LOC102553561 Neighboring gene uncharacterized LOC120096015 Neighboring gene checkpoint kinase 2 Neighboring gene HscB mitochondrial iron-sulfur cluster co-chaperone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. Izumiyama T, et al. Gene, 2012 Dec 15. PMID 23036704
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      51002816..51443461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271797.1 → XP_063127867.1  tetratricopeptide repeat protein 28 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ASI5

    2. XM_063271796.1 → XP_063127866.1  tetratricopeptide repeat protein 28 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRJ0, D3ZXP1

    3. XM_006249584.5 → XP_006249646.1  tetratricopeptide repeat protein 28 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBH2, A0A8I6ASI5
      Related
      ENSRNOP00000076352.1
      Conserved Domains (7) summary
      smart00028
      Location:388 → 420
      TPR; Tetratricopeptide repeats
      COG0457
      Location:688 → 989
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:85 → 115
      TPR; TPR repeat [structural motif]
      pfam12770
      Location:1384 → 1707
      CHAT; CHAT domain
      pfam13176
      Location:953 → 988
      TPR_7; Tetratricopeptide repeat
      pfam13414
      Location:88 → 151
      TPR_11; TPR repeat
      pfam13424
      Location:309 → 380
      TPR_12; Tetratricopeptide repeat

    4. XM_039090202.2 → XP_038946130.1  tetratricopeptide repeat protein 28 isoform X5

      Conserved Domains (5) summary
      TIGR02917
      Location:174 → 980
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:424 → 452
      TPR; TPR repeat [structural motif]
      pfam05109
      Location:1891 → 2183
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13424
      Location:104 → 176
      TPR_12; Tetratricopeptide repeat
      pfam12770
      Location:1220 → 1543
      CHAT; CHAT domain

    5. XM_006249585.5 → XP_006249647.1  tetratricopeptide repeat protein 28 isoform X4

      UniProtKB/TrEMBL
      D3ZXP1
      Related
      ENSRNOP00000044499.6
      Conserved Domains (7) summary
      smart00028
      Location:276 → 308
      TPR; Tetratricopeptide repeats
      COG0457
      Location:576 → 877
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:476 → 504
      TPR; TPR repeat [structural motif]
      pfam12770
      Location:1272 → 1595
      CHAT; CHAT domain
      pfam13176
      Location:841 → 876
      TPR_7; Tetratricopeptide repeat
      pfam13414
      Location:960 → 1028
      TPR_11; TPR repeat
      pfam13424
      Location:197 → 268
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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