CIITA class II major histocompatibility complex transactivator [Gallus gallus (chicken)] - Gene

Summary

Symbol: CIITAprovided by CGNC
Full Name: class II major histocompatibility complex transactivatorprovided by CGNC
Primary source: CGNC:50302
See related: Ensembl:ENSGALG00010019376
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	14	NC_052545.1 (9077183..9117051, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	14	NC_052586.1 (9074070..9114476, complement)

Chromosome 14 - NC_052545.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This investigation may indicate that CIITA molecule has an important role in the chicken immune responses as well as human and other animals.
Title: Molecular characterization of chicken class II transactivator gene.

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MHC class I biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MHC class II biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: MHC class II transactivator

Names: class II transactivator; class II, major histocompatibility complex, transactivator-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

9077183..9117051 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040647911.2 → XP_040503845.1 MHC class II transactivator isoform X1

UniProtKB/TrEMBL

A0A8V0ZB38

Conserved Domains (2) summary

sd00033
Location:1029 → 1059

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:830 → 1155

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_040647910.2 → XP_040503844.1 MHC class II transactivator isoform X1

UniProtKB/TrEMBL

A0A8V0ZB38

Conserved Domains (2) summary

sd00033
Location:1029 → 1059

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:830 → 1155

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_040647912.2 → XP_040503846.1 MHC class II transactivator isoform X2

Conserved Domains (2) summary

sd00033
Location:1028 → 1058

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:829 → 1154

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_004945316.5 → XP_004945373.2 MHC class II transactivator isoform X1

UniProtKB/TrEMBL

A0A8V0ZB38

Related

ENSGALP00010027879.1, ENSGALT00010046857.1

Conserved Domains (2) summary

sd00033
Location:1029 → 1059

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:830 → 1155

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_040647913.2 → XP_040503847.1 MHC class II transactivator isoform X4

Conserved Domains (2) summary

sd00033
Location:976 → 1006

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:777 → 1102

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_025155251.3 → XP_025011019.2 MHC class II transactivator isoform X3

UniProtKB/TrEMBL

A0A8V0ZH17

Related

ENSGALP00010027877.1, ENSGALT00010046853.1

Conserved Domains (2) summary

sd00033
Location:977 → 1007

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:778 → 1103

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_414932.8 → XP_414932.3 MHC class II transactivator isoform X5

UniProtKB/TrEMBL

A0A8V0Z3R7

Related

ENSGALP00010027876.1, ENSGALT00010046851.1

Conserved Domains (2) summary

sd00033
Location:967 → 997

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:768 → 1093

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_040647914.2 → XP_040503848.1 MHC class II transactivator isoform X5

UniProtKB/TrEMBL

A0A8V0Z3R7

Conserved Domains (2) summary

sd00033
Location:967 → 997

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:768 → 1093

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_046900873.1 → XP_046756829.1 MHC class II transactivator isoform X5

UniProtKB/TrEMBL

A0A8V0Z3R7

RNA

XR_005839988.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

9074070..9114476 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040684075.2 → XP_040540009.1 MHC class II transactivator isoform X1

Conserved Domains (2) summary

sd00033
Location:1029 → 1059

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:830 → 1155

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_040684074.2 → XP_040540008.1 MHC class II transactivator isoform X1

Conserved Domains (2) summary

sd00033
Location:1029 → 1059

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:830 → 1155

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_040684076.2 → XP_040540010.1 MHC class II transactivator isoform X2

Conserved Domains (2) summary

sd00033
Location:1028 → 1058

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:829 → 1154

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_040684078.2 → XP_040540012.1 MHC class II transactivator isoform X4

Conserved Domains (2) summary

sd00033
Location:976 → 1006

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:777 → 1102

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_040684077.2 → XP_040540011.1 MHC class II transactivator isoform X3

Conserved Domains (2) summary

sd00033
Location:977 → 1007

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:778 → 1103

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_040684079.2 → XP_040540013.1 MHC class II transactivator isoform X5

Conserved Domains (2) summary

sd00033
Location:967 → 997

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:768 → 1093

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_040684080.2 → XP_040540014.1 MHC class II transactivator isoform X5

Conserved Domains (2) summary

sd00033
Location:967 → 997

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:768 → 1093

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_046927662.1 → XP_046783618.1 MHC class II transactivator isoform X5