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    AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) [ Canis lupus familiaris (dog) ]

    Gene ID: 497070, updated on 11-Apr-2024

    Summary

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    Gene symbol
    AKR1C3
    Gene description
    aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
    See related
    Ensembl:ENSCAFG00845002994
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    PGFS
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    Genomic context

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    See AKR1C3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (31042072..31071570)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (27694812..27719595)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (29696602..29721383)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (28135405..28160172)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (28972376..28997157)

    Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene urocortin 3 Neighboring gene uncharacterized LOC119870172 Neighboring gene aldo-keto reductase family 1 member E2 Neighboring gene uncharacterized LOC102156268

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of prostaglandins in reproductive physiology. Bardin TP. Ohio State Med J, 1970 Oct. PMID 4918753
    2. Biosynthesis and degradation of canine placental prostaglandins: prepartum changes in expression and function of prostaglandin F2α-synthase (PGFS, AKR1C3) and 15-hydroxyprostaglandin dehydrogenase (HPGD). Gram A, et al. Biol Reprod, 2013 Jul. PMID 23677986
    3. Canine prostaglandin F2alpha receptor (FP) and prostaglandin F2alpha synthase (PGFS): molecular cloning and expression in the corpus luteum. Kowalewski MP, et al. Anim Reprod Sci, 2008 Aug. PMID 17689894

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. utero/placental expression identified in the superficial uterine glands throughout gestation and in the trophoblast cells within the feto-maternal contact zone during placentation
      Title: Biosynthesis and degradation of canine placental prostaglandins: prepartum changes in expression and function of prostaglandin F2α-synthase (PGFS, AKR1C3) and 15-hydroxyprostaglandin dehydrogenase (HPGD).
    2. The cloning and expression of prostaglandin F2alpha receptor (FP) and prostaglandin F2alpha synthase (PGFS)in the canine corpus luteum in nonpregnant dogs during diestrus are reported.[PF; PGFS]
      Title: Canine prostaglandin F2alpha receptor (FP) and prostaglandin F2alpha synthase (PGFS): molecular cloning and expression in the corpus luteum.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables androsterone dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables bile acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ketosteroid monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in daunorubicin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in doxorubicin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in progesterone metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in prostaglandin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldo-keto reductase family 1 member C21
    Names
    prostaglandin F synthase
    NP_001012344.1
    XP_038513775.1
    XP_038513776.1
    XP_038513777.1
    XP_038513778.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012344.1 → NP_001012344.1  aldo-keto reductase family 1 member C21

      See identical proteins and their annotated locations for NP_001012344.1

      Status: PROVISIONAL

      Source sequence(s)
      AY875970
      UniProtKB/TrEMBL
      A0A8C0LYD8, A0A8C0M3N9, Q5FYA7
      Related
      ENSCAFP00845004208.1, ENSCAFT00845005292.1
      Conserved Domains (2) summary
      COG0656
      Location:9 → 306
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:4 → 297
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051806.1 Reference ROS_Cfam_1.0

      Range
      31042072..31071570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038657848.1 → XP_038513776.1  aldo-keto reductase family 1 member C21 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JT19, A0A8C0M3N9, A0A8C0PUD9, A0A8I3MRB2
      Conserved Domains (1) summary
      cd19108
      Location:7 → 308
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

    2. XM_038657847.1 → XP_038513775.1  aldo-keto reductase family 1 member C21 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JT19, A0A8C0M3N9, A0A8C0PUD9, A0A8I3MRB2
      Conserved Domains (1) summary
      cd19108
      Location:7 → 308
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

    3. XM_038657850.1 → XP_038513778.1  aldo-keto reductase family 1 member C21 isoform X3

      UniProtKB/TrEMBL
      A0A8C0M3N9
      Conserved Domains (1) summary
      cl00470
      Location:1 → 254
      AKR_SF; Aldo-keto reductase (AKR) superfamily

    4. XM_038657849.1 → XP_038513777.1  aldo-keto reductase family 1 member C21 isoform X2

      UniProtKB/TrEMBL
      A0A8C0M3N9, A0A8C0RVJ1
      Conserved Domains (1) summary
      cd19108
      Location:8 → 286
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049262.1 Alternate UMICH_Zoey_3.1

      Range
      28135405..28160172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

      Range
      28972376..28997157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

      Range
      29696602..29721383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      27694812..27719595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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